Chemotherapy and resection for gastric cancer with synchronous liver metastases

Table 1 Clinicopathological characteristics of patients with and without hepatectomy

Clinicopathological characteristics	With hepatectomy	Without hepatectomy
Sex
Male	12	59
Female	8	35
Primary gastric tumors
Median diameter of primary gastric tumors (cm)	4.3 (2.4-8.8)	4.5 (2.1-9.3)
Tumor location
Upper	7	27
Lower	13	67
Pathological T-stage of the primary1
pT1	2	9
pT2	4	21
pT3	12	51
pT4	2	13
N stage of the primary tumor
N0	3	18
N1	9	48
N2	5	21
N3	3	7
Differentiation of the primary tumor
Well	2	9
Moderate	14	64
Poor	4	21
Liver metastases
Median diameter of liver metastases (cm)	4.1 (1.7-16)	4.5 (1.5-18)
No. of metastases
Solitary	8	43
≥ 2	12	51
Vascular invasion of metastases
Present	3	26
Absent	17	68
Site of metastases
Left lobe	4	18
Right lobe	7	31
Bilobar	9	45
Interruption of hepatic hilum
Present	5	28
Absent	15	66

¹According to tumor-nodes-metastasis-classification.

Table 2 Response evaluation after first two courses of preoperative chemotherapy

No. of cases	Diameter of metastases (mm3)		Evaluation of response (according to RECIST)	Adverse events grade
	Pre-chem	Post-chem
1	128	0-10	CR	2
2	135	56	PR	3
3	188	65	PR	1
4	64	22	PR	2
5	48	24	PR	2
6	148	38	PR	1
7	205	83	PR	1
8	162	65	PR	2
9	78	30	PR	2
10	228	94	PR	3
11	206	108	PR	2
12	144	56	PR	1
13	67	41	PR	1
14	104	67	PR	3
15	163	103	PR	2
16	134	92	PR	3
17	88	61	PR	3
18	225	134	PR	2
19	143	96	PR	2
20	78	43	PR	3

When the number of liver lesions was > 5, the diameters of the five largest lesions were summed. RECIST: Response evaluation criteria in solid tumors; CR: Complete response; PR: Partial response; Pre-chem: Pre-chemotherapy; Post-chem: Post-chemotherapy.