Effects of different resuscitation fluid on severe acute pancreatitis

Table 1 Demographic information of patients with severe acute pancreatitis treated by different resuscitation fluid (mean ± SD)

	NS group (n = 40)	SH group (n = 40)	SHG group (n = 40)
Age (yr)	41.86 ± 13.85	44.50 ± 9.77	45.11 ± 11.57
Sex n (%)
Male	20 (50)	22 (55)	21 (52.5)
Female	20 (50)	18 (45)	19 (47.5)
Height (cm)	165.86 ± 6.04	165.00 ± 9.03	169.25 ± 6.67
Weight (kg)	66.5 ± 8.63	69.00 ± 9.68	72.38 ± 8.43
APACHE II score	11.2 ± 0.7	10.9 ± 0.6	11.3 ± 0.4
MAP (mmHg)	62.3 ± 9.3	64.8 ± 9.2	63.6 ± 8.9
BUN/Cr ratio	23.9 ± 3.6	24.2 ± 3.2	23.7 ± 3.7

No significant differences were observed among the study groups regarding demographic data. APACHE: Acute physiology and chronic health evaluation; MAP: Mean arterial pressure; BUN/Cr: Blood urea nitrogen/creatinine; NS group: Normal saline; SH group: Combination of normal saline and hydroxyethyl starch; SHG group: Combination of normal saline, hydroxyethyl starch and glutamine.

Table 2 Window of manifestation to resuscitation, time of resuscitation endpoint, volume of resuscitation fluid, urine output, and abdominal drainage fluid in different groups

	NS group	SH group	SHG group
Window to resuscitation (h)	12.8 ± 6.7	13.1 ± 5.4	12.2 ± 6.3
Time to endpoint (d)	5.8 ± 0.25	3.9 ± 0.231	4.1 ± 0.211
Resuscitation fluid (mL/kg per day)	61.79 ± 7.61	46.93 ± 12.381	44.75 ± 8.531
Urine output/d (mL/kg per day)	31.3 ± 5.47	28.71 ± 11.62	27.94 ± 10.62
Abdominal drainage fluid (mL/kg per day)	11.32 ± 2.13	6.28 ± 3.261	6.35 ± 1.421

¹P < 0.05 vs normal saline (NS group). Statistic measure of variation is standard error. SH group: Combination of normal saline and hydroxyethyl starch; SHG group: Combination of normal saline, hydroxyethyl starch and glutamine.

Table 3 Complications and outcomes of patients treated by different resuscitation fluid

	NS group	SH group	SHG group
Renal dysfunction	11	31	41
ARDS	16	61	71
MODS	10	31	31
ACS	6	11	11
Lung infection	13	51	51
Abdominal infection	11	31	21
Sepsis	3	2	3
Operation	6	2	2
LOIS	14 ± 8.2	10 ± 9.41	11 ± 6.31
LOHS	31 ± 22.8	22 ± 18.91	21 ± 23.71
Mortality	5	2	3

¹P < 0.05 vs normal saline (NS group). SH group: Combination of normal saline and hydroxyethyl starch; SHG group: Combination of normal saline, hydroxyethyl starch and glutamine; ARDS: Acute respiratory distress syndrome; MODS: Multiple organ dysfunction syndrome; ACS: Abdominal compartment syndrome; LOIS: Length of intensive care unit stay; LOHS: Length of hospital stay.