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©2013 Baishideng Publishing Group Co.
World J Gastroenterol. Apr 7, 2013; 19(13): 2019-2027
Published online Apr 7, 2013. doi: 10.3748/wjg.v19.i13.2019
Published online Apr 7, 2013. doi: 10.3748/wjg.v19.i13.2019
Table 1 microRNA expression in gastric cancer in 2008-2012
Group | Method | Sample | Upregulated | Downregulated |
Katada et al[29] | TaqManmiRNA assays + qRT-PCR | 42 undifferentiated gastric cancer and controls | miR-34b miR-34c miR-128a | miR-128b, miR-129, miR-148 |
Guo et al[30] | Microarray | 3 gastric cancers and adjacent normal tissues | miR-20b, miR-20a, miR-17, miR-106a, miR-18a, miR-21, miR-106b, miR-18b, miR-421, miR-340, miR-19a, miR-658 | miR-768-3p, miR-378, miR-31, miR-139-5p, miR-195, miR-497, miR-133b, |
Yao et al[31] | Microarray + qRT-PCR | 10 gastric cancers and adjacent normal tissue | miR-223, miR-106b, miR-147, miR-34a, miR-130b, miR-106a, miR-18a, miR-17, miR-98, miR-616,miR-181a-2, miR-185, miR-1259, miR-601, miR-196a, miR-221, miR-302f, miR-340, miR-337-3p, miR-520c-3p, miR-575 and miR-138 | miR-638, miR-378 |
Luo et al[32] | Microarray + qRT-PCR | 24 gastric cancers | MiR-26b, miR-30a-5p, miR-212, miR-320, miR-379, miR-518b, miR-409-3b | MiR-9, miR-19b, miR-155, miR-188, miR-197, miR-338, miR-370, miR-383, miR-433, miR-490, miR-503, miR-545, miR-551a, miR-567, miR-575, miR-611, miR-630, miR-649, miR-652 |
Ueda et al[33] | Microarray + qRT-PCR | 353 (184 gastric cancers 169 controls) | miR-181d, miR-181a-1, miR-181a-2, miR-181c, miR-181b-1, miR-181b-2, miR-21, miR-25, miR-92-1, miR-92-2, miR-93, miR-17-5p, miR-106a, miR-20b, miR-135a-1, miR-135a-2, miR-425-5p, miR-106b, miR-20a, miR-19b-1, miR-19b-2 | miR-148a, miR-148b, miR-375, miR-29b-1, miR-29b-2, miR-29c, miR-152, miR-218-2miR-451, miR-30d |
Tsukamoto et al[34] | Microarray (470) + qRT-PCR | 22 gastric cancers | miR-18a, miR-106a, miR-17, miR-146a, miR-93, miR-19a, miR-20a, miR-20b, miR-25, miR-15b, miR-425, miR-92a, miR-194, miR-10a, miR-222, miR-7, miR-106b, miR-320a, miR-21, miR-34a, miR-19b, miR-103, miR-215, miR-192, miR-429, miR-27a, miR-223, miR-23a, miR-107, miR-200b, miR-24, miR-15a, miR-16 | miR-375, miR-29c, miR-148a, miR-30a-5p, miR-30e-5p, miR-638 |
Li et al[35] | TaqManmiRNA assays + qRT-PCR | 30 gastric cancer and controls | miR-223, miR-21, miR-23b, miR-222, miR-25, miR-23a, miR-221, miR-107, miR-103, miR-99a, miR-100, miR-125b, miR-92, miR-146a, miR-214 and miR-191, | let-7a, miR-126, miR-210, miR-181b, miR-197, miR-30aa-5p |
Carvalho et al[36] | Microarray + qRT-PCR | 76 gastric cancers | miR-582-5p, miR-151-5p, miR-296-5p, miR-30b, miR-513-5p, miR-335, miR-576-5p, miR-219-2-3p, miR-331-5p, miR-889, miR-152, miR-992, miR-93, miR-519c, miR-599, miR-520a-5p, miR-631, miR-550, miR-136, miR-22, miR-515-5p, miR-127-3p, miR-374a, miR-181a, miR-192, miR-532-3p, miR-30d, miR-640, miR-425, miR-92b, miR-501-5p, miR-514, miR-576-3p, miR-519e, miR-149, miR-219-1-3p, miR-424, miR-220, miR-96, miR-218-2, miR-649, miR-215, miR-182, miR-122, miR-524-3p, miR-187, miR-526b, miR-770-5p, miR-545, miR-200b, miR-9, miR-141, miR-579, miR-493, miR-137, miR-216a, miR-503, miR-126, miR-23b, miR-99b, miR-101, miR-323-3p, miR-25, miR-92a-1, miR-429 | miR-451, miR-502-3p, miR-101 miR-33a, miR-516a-3p/miR-516b |
Table 2 Expression of miRNA and area under curve, sensitivity and specificity in serum samples of patients with gastric cancer
Group | Sample | MicroRNA | AUC | Method | Sensitivity/specificity (%) |
Liu et al[49] | 61 GC/61 C | miR-378↑ | 0.861 | qRT-PCR | 87.5/70.7 |
Liu et al[50] | 164 GC/127 C | (miR-1, miR-20a, miR-27a, miR-34, miR-423-5P)↑ | 0.879 | Microarray + qRT-PCR | 79.3/86.5 |
0.831 | |||||
Konish et al[51] | 56 GC/30 C | miR-451↑ | 0.96 | Microarray + qRT-PCR | 96.0/100 |
miR-486↑ | 0.92 | 86.0/97.0 | |||
Song et al[52] | 82 GC/82 C | miR-221, miR-744 and miR-376c↑ | NA | qRT-PCR | 82.4/58.8 |
Zhou et al[53] | 90 GC/27 C | miR-106a↑ | 0.684 | Microarray + qRT-PCR | 48.2/90.2 |
miR-17↑ | 0.743 | 51.9/92.7 | |||
Wang et al[54] | 174 GC/39 C | miR-21↑ | 0.81 | Microarray + qRT-PCR | 56.7/94.9 |
Tsujiura et al[55] | 69 GC/30 C | miR-106b↑ | 0.72 | Microarray + qRT-PCR | NA |
miR-106a↑, let-7a↓ | 0.879 | 85.5/80.0 |
Table 3 Gastric cancer with potential predictive role of miRNAs
Potential predictive role of miRNA | ||
MiRNAs of high expression | MiRNAs of low expression | |
Short survival time | miRNA-20b, miRNA-150[29], miRNA-142-5p[61], miRNA-375, miRNA-214[62] | miRNA-451, let7g1, miRNA-4331[33], miRNA-125-5p3[63] |
Lymph node metastasis | miRNA-27a[29], miRNA-650[64] | miRNA-126[65], miRNA-146a[66], miRNA-148[67], miRNA-218[68], miRNA-335[69], miRNA-429[70] |
Relapse | miRNA-375[61], miRNA-4512, miRNA-199-3p2, miRNA-1952[71] | miRNA-142-5p[61] |
Advanced gastric cancer | miRNA-2214[72] | miRNA-126[65], miRNA-148a[67], miRNA-218[68] |
Invasion, metastasis | miRNA-223[35], miRNA-148a[73], miRNA-107[74] | miRNA-610[75], miRNA-200b5[76], miRNA-7[77] |
Table 4 Expression of miRNA and prediction of the effect of chemotherapy and radiotherapy
Upregulated | Downregulated | |
Chemosensitivity | (let-7g, miR-342, miR-16, miR-181, miR-1, miR-34)1[81] | |
Chemoresistance | (miR-518f, miR-520a, miR-520d, miR-519e, miR-363, miR-517)1[81] | (miR-196a, miR-200family, miR-338, miR-126, miR-31, miR-98, let-7g, miR-7)2[82] miR-15b, miR-16[83] |
Radiosensitivity | miR-451[85] | |
Radioresistance | miR-221/222[97] |
- Citation: Gao M, Yin H, Fei ZW. Clinical application of microRNA in gastric cancer in Eastern Asian area. World J Gastroenterol 2013; 19(13): 2019-2027
- URL: https://www.wjgnet.com/1007-9327/full/v19/i13/2019.htm
- DOI: https://dx.doi.org/10.3748/wjg.v19.i13.2019