Expression of OCT4 in human esophageal squamous cell carcinoma is significantly associated with poorer prognosis

Table 1 Correlation of OCT4 expression with clinicopathological features of esophageal squamous cell carcinoma

Parameters	Cases	OCT4			P value
		Staining scores
		0	1	2
Age					0.493
< 51	48	30	6	12
51-60	52	39	6	7
> 60	53	36	9	8
Gender					0.088
Male	93	70	10	13
Female	60	35	11	14
Location					0.716
Upper	14	10	2	2
Middle	101	71	11	19
Lower	35	23	7	5
Missing	3
Size					0.175
< 31 mm	25	22	2	1
31-60 mm	105	67	17	21
> 60 mm	14	10	1	3
Missing	9	6	1	2
Lymph node metastasis					0.296
-	99	72	11	16
+	54	33	10	11
UICC stage					0.276
I + II	100	73	12	15
III + IV	53	32	9	12
T stage					0.407
I	5	2	1	2
II	39	29	6	4
III	100	68	14	18
IV	9	6	0	3
Histological grade					< 0.001a
Well	53	48	5	0
Moderate	60	48	3	9
Poor	40	9	13	18
Patients at follow-up					0.033a
Alive	56	45	3	8
Dead	97	60	18	19

UICC: International Union Against Cancer.

^aP < 0.05.

Table 2 Immunohistochemical staining results for OCT4

Score	OCT4
	n	%
0	100	65.4
1	2	1.3
2	3	2
3	15	9.8
4	6	3.9
6	17	11.1
9	10	6.5
Total	153	100

Table 3 Multivariate analysis of death events related to esophageal squamous cancer

Parameters	Ratio of risk (RR)	95% CI	P value
Age	1.057	0.806-1.385	0.689
Gender	1.119	0.709-1.767	0.628
Location	1.170	0.785-1.745	0.441
Size	0.925	0.585-1.462	0.739
Lymph node metastasis	2.280	1.429-3.636	0.001a
T stage	1.885	1.204-2.951	0.006a
Histological grade	3.085	2.242-4.247	< 0.001a
OCT4	2.625	1.528-3.972	< 0.001a

CI: Confidence interval;

^aP < 0.05.