Response evaluation of chemotherapy in metastatic colorectal cancer by contrast enhanced ultrasound

Table 1 Time to peak and to peak quotient in liver metastasis

	Date 1	Date 2	Date 3
Time to peak
Responder (CR, PR)
mean ± SD	9.1 ± 2.9	12.1 ± 2.3	14.6 ± 3.9
95% CI	7.3-10.8	10.7-13.6	12.2-17.0
Non-responder (SD1,PD)
mean ± SD	14.8 ± 3.7	16.7 ± 2.8	16.4 ± 2.6
95% CI	12.8-16.7	15.2-18.2	15.0-17.7
P value compared responder with non-responder	< 0.001	< 0.001	NS
Time to peak quotient
Responder (CR, PR)
mean ± SD	57.5 ± 11.8	80.5 ± 5.4	93.7 ± 9.2
95% CI	50.3-64.6	77.2-83.7	88.2-99.2
Non-responder (SD1, PD)
mean ± SD	98.7 ± 12.6	100.6 ± 13.3	96.9 ± 9.7
95% CI	92.2-105.2	93.8-107.5	91.9-101.9
P value compared responder with non-responder	< 0.001	< 0.001	NS

NS: Not significant; CR: Complete response; PR: Partial response; SD¹: Stable disease; PD: Progressive disease; CI: Confidence interval.