Effectiveness of 5-flurouracil-based neoadjuvant chemotherapy in locally-advanced gastric/gastroesophageal cancer: A meta-analysis

Table 1 Characteristics of the included studies in the meta-analysis

No.	Authors and year of publication	Country	Patients (n)		Treatment group		Control group
			Treatment	Control	Pre-op	Post-op	Pre-op	Post-op
1	Schuhmacher et al[15], 2010	Germany	72	72	5-FU + DDP	None	None	None
2	Boige et al[11], 2011	France	113	111	FP	FP	None	None
3	Cunningham et al[12], 2006	United Kingdom	250	253	ECF	ECF	None	None
4	Hartgrink et al[13], 2004	Holland	27	29	FAMTX		None	None
5	Zhang et al[17], 2004	China	37	54	IV (no details)		None	None
6	Kobayashi et al[14], 2000	Japan	91	80	5-FU (oral)	CT	None	None
7	Wang et al[16], 2000	China	30	30	5-FU (oral)		None	None

5-FU: 5-fluorouracil; DDP: Cisplatin; FP: 5-FU/cisplatin; ECF: Epirubicin/cyclophosphamide/5-FU; FAMTX: 5-FU/adriamycin/methotrexate; CT: Chemotherapy; IV: Intravenous; Pre-op: Preoperative; Post-op: Postoperative.

Table 2 Origin of the included studies and Jadad score

No.	Authors	Titles	Jadad score
1	Schuhmacher et al[15]	Neoadjuvant chemotherapy compared with surgery alone for locally advanced cancer of the stomach and cardia: European Organization for Research and Treatment of Cancer randomized trial 40954	4
2	Boige et al[11]	Perioperative chemotherapy compared with surgery alone for resectable gastroesophageal adenocarcinoma: an FNCLCC and FFCD multicenter phase III trial	4
3	Cunningham et al[12]	Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer	7
4	Hartgrink et al[13]	Neoadjuvant chemotherapy for operable gastric cancer: long-term results of the Dutch randomized FAMTX trial	5
5	Zhang et al[17]	Clinical significance of preoperative regional intra-arterial infusion chemotherapy for advanced gastric cancer	2
6	Kobayashi et al[14]	Long-term outcome of preoperative chemotherapy with 5'-deoxy-5-fluorouridine (5'-DFUR) for gastric cancer	3
7	Wang et al[16]	A favorable impact of preoperative FPLC chemotherapy on patients with gastric cardia cancer	3

FAMTX: 5-FU/adriamycin/methotrexate; FPLC: Fluorouracili polyphase liposome composita pro orale; FNCLCC: Fe´de´ ration Nationale des Centres de Lutte Contrele Cancer; FFCD: Fe´de´ ration Francophonede Cance´ rologie Digestive Collaborative Groups.

Table 3 Quality assessment of the included trials

Authors and year of publication	Randomization	Allocation concealment	Blinding	Withdrawal and dropout	Jadad score
Schuhmacher et al[15], 2010	Without details	Without details	Without details	Well reported	4
Boige et al[11], 2011	Without details	Without details	Without details	Well reported	4
Cunningham et al[12], 2006	Well reported	Envelope	Double-blind	Well reported	7
Hartgrink et al[13], 2004	Well reported	Envelope	No	Well reported	5
Zhang et al[17], 2004	Without details	None	No	Well reported	2
Kobayashi et al[14], 2000	Well reported	Envelope	No	Well reported	3
Wang et al[16], 2000	Without details	Without details	No	Well reported	3