Impact of intestinal ischemia/reperfusion and lymph drainage on distant organs in rats

Table 1 Serum levels of endotoxin and high mobility group protein box 1 in the ischemia/reperfusion and ischemia/reperfusion + drainage groups compared to respective controls (mean ± SD, n = 8)

Groups	Endotoxin (EU/mL)	HMGB1 (ng/mL)
Blank	0.014 ± 0.005	0.277 ± 0.292
Sham	0.017 ± 0.009a	0.476 ± 0.406
I/R + D	0.024 ± 0.003ace	4.906 ± 0.552ac
I/R	0.033 ± 0.004ac	5.473 ± 0.963ac

^aP < 0.05 vs the blank group;

^cP < 0.05 vs the sham group;

^eP < 0.05 vs the I/R group. I/R: Ischemia/reperfusion; I/R + D: Ischemia/reperfusion + drainage; HMGB1: High mobility group protein box 1.

Table 2 Serum levels of cytokines in the ischemia/reperfusion and ischemia/reperfusion + drainage groups compared to respective controls (mean ± SD, n = 8)

Groups	TNF-α(pg/mL)	IL-1β(pg/mL)	IL-6 (pg/mL)	sICAM-1 (ng/mL)
Blank	13.799 ± 6.456	22.476 ± 8.498	8.687 ± 0.761	30.901 ± 6.962
Sham	18.863 ± 6.679	38.178 ± 7.157	11.566 ± 2.973	33.073 ± 5.957
I/R + D	25.381 ± 9.281ae	65.829 ± 10.888ace	19.204 ± 4.136ace	48.401 ± 6.547ace
I/R	45.863 ± 11.553ac	144.646 ± 29.378ac	41.773 ± 9.753ac	97.360 ± 12.714ac

^aP < 0.05 vs the blank group;

^cP < 0.05 vs the sham group;

^eP < 0.05 vs the I/R group. I/R: Ischemia/reperfusion; I/R + D: Ischemia/reperfusion + drainage; TNF: Tumor necrosis factor; IL: Interleukin; sICAM: Soluble cell adhesion molecule.