Astragalus polysaccharides can regulate cytokine and P-glycoprotein expression in H22 tumor-bearing mice

doi:10.3748/wjg.v18.i47.7079

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 18, Issue 47

This Article

Citation of this article

Corresponding Author of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (5806)

All Articles published online

The chart showing PDF series, HTML series, Figures (1-3) series, Tables (1-3) series.

Item

Count

PDF

472

HTML

4849

Figures (1-3)

262

Tables (1-3)

223

Sum=5806

Dec 21, 2012 (publication date) through Jan 23, 2025

Times Cited of This Article

Times Cited (75)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Brief Article

World J Gastroenterol. Dec 21, 2012; 18(47): 7079-7086
Published online Dec 21, 2012. doi: 10.3748/wjg.v18.i47.7079

Table 1 Tumor inhibition rate and immune organ index (n = 10)

Group	Tumor weight (g)	Inhibition rate (%)	Spleen index	Thymus index
ADM + RFP	5.37 ± 1.31^a	60.00	0.51 ± 0.28^a	0.15 ± 0.04
ADM	5.32 ± 2.03^a	60.36	0.39 ± 0.17^a	0.13 ± 0.04
NS	13.42 ± 1.03	-	0.74 ± 0.21	0.15 ± 0.09
ADM + APS (50 mg/kg)	3.64 ± 1.54^a^c	72.88^c	0.65 ± 0.22^c	0.15 ± 0.05
ADM + APS (100 mg/kg)	3.57 ± 1.66^a^c	73.40^c	0.62 ± 0.34^c	0.20 ± 0.06^c
ADM + APS (200 mg/kg)	3.01 ± 1.95^a^c	77.57^c	0.67 ± 0.20^c	0.47 ± 0.12^a^c
ADM + VER	4.75 ± 1.86^a	69.45	0.50 ± 0.17^a	0.13 ± 0.03

^aP < 0.05 vs normal saline (NS) group;

^cP < 0.05 vs adriamycin (ADM) group. RFP: Rifampicin; APS: Astragalus polysaccharides; VER: Verapamil.

Table 2 Expression of interleukin-1α, interleukin-2, interleukin-6, tumor necrosis factor-α, and interleukin-10 (n = 10)

Group	mean ± SD (pg/mL)
	IL-1α	IL-2	IL-6	TNF-α	IL-10
ADM + RFP	5.89 ± 2.12	6.11 ± 2.9^a	10.99 ± 2.09^a	9.00 ± 1.21	55.98 ± 2.43
ADM	4.63 ± 3.2	5.23 ± 2.12^a	10.78 ± 3.13^a	8.01 ± 1.22	54.01 ± 2.33
NS	13.21 ± 2.01^c	11.35 ± 2.09^c	29.55 ± 8.97^c	23.1 ± 1.83^c	56.67 ± 4.32
ADM + APS (50 mg/kg)	14.34 ± 1.78^c	12.11 ± 3.08^c	41.57 ± 6.42^a^c	29.97 ± 4.09^c	41.23 ± 3.12^a^c
ADM + APS (100 mg/kg)	25.31 ± 2.98^a^c	19.98 ± 3.21^a^c	38.82 ± 5.88^a^c	33.23 ± 3.99^a^c	27.23 ± 7.68^a^c
ADM + APS (200 mg/kg)	22.45 ± 4.01^a^c	26.67 ± 7.21^a^c	40.99 ± 5.54^a^c	44.78 ± 3.98^a^c	24.87 ± 5.78^a^c
ADM + VER	7.34 ± 2.11	5.77 ± 2.11	9.34 ± 1.75^a	9.11 ± 2.01	50.66 ± 1.12

^aP < 0.05 vs normal saline (NS) group;

^cP < 0.05 vs adriamycin (ADM) group. IL: Interleukin; TNF-α: Tumor necrosis factor-α; RFP: Rifampicin; APS: Astragalus polysaccharides; VER: Verapamil.

Table 3 Multidrug resistance 1 mRNA expression in tumor tissue (2^-∆∆Ct) (n = 10)

Group	2^-∆∆Ct ( mean ± SD )
ADM + RFP	5.02 ± 1.82
ADM	4.26 ± 1.51
NS	1.02 ± 0.05^a^c
ADM + APS (50 mg/kg)	0.48 ± 0.13^a^c
ADM + APS (100 mg/kg)	0.36 ± 0.03^a^c
ADM + APS (200 mg/kg)	0.21 ± 0.04^a^c
ADM + VER	0.28 ± 0.09^a^c

^aP < 0.05 vs adriamycin (ADM) group;

^cP < 0.05 vs ADM + rifampicin (RFP) group. NS: Normal saline; APS: Astragalus polysaccharides; VER: Verapamil.

Citation: Tian QE, Li HD, Yan M, Cai HL, Tan QY, Zhang WY. Astragalus polysaccharides can regulate cytokine and P-glycoprotein expression in H22 tumor-bearing mice. World J Gastroenterol 2012; 18(47): 7079-7086
URL: https://www.wjgnet.com/1007-9327/full/v18/i47/7079.htm
DOI: https://dx.doi.org/10.3748/wjg.v18.i47.7079