Astragalus polysaccharides can regulate cytokine and P-glycoprotein expression in H22 tumor-bearing mice

doi:10.3748/wjg.v18.i47.7079

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 21, 2012; 18(47): 7079-7086
Published online Dec 21, 2012. doi: 10.3748/wjg.v18.i47.7079

Table 1 Tumor inhibition rate and immune organ index (n = 10)

Group	Tumor weight (g)	Inhibition rate (%)	Spleen index	Thymus index
ADM + RFP	5.37 ± 1.31^a	60.00	0.51 ± 0.28^a	0.15 ± 0.04
ADM	5.32 ± 2.03^a	60.36	0.39 ± 0.17^a	0.13 ± 0.04
NS	13.42 ± 1.03	-	0.74 ± 0.21	0.15 ± 0.09
ADM + APS (50 mg/kg)	3.64 ± 1.54^a^c	72.88^c	0.65 ± 0.22^c	0.15 ± 0.05
ADM + APS (100 mg/kg)	3.57 ± 1.66^a^c	73.40^c	0.62 ± 0.34^c	0.20 ± 0.06^c
ADM + APS (200 mg/kg)	3.01 ± 1.95^a^c	77.57^c	0.67 ± 0.20^c	0.47 ± 0.12^a^c
ADM + VER	4.75 ± 1.86^a	69.45	0.50 ± 0.17^a	0.13 ± 0.03

^aP < 0.05 vs normal saline (NS) group;

^cP < 0.05 vs adriamycin (ADM) group. RFP: Rifampicin; APS: Astragalus polysaccharides; VER: Verapamil.

Table 2 Expression of interleukin-1α, interleukin-2, interleukin-6, tumor necrosis factor-α, and interleukin-10 (n = 10)

Group	mean ± SD (pg/mL)
	IL-1α	IL-2	IL-6	TNF-α	IL-10
ADM + RFP	5.89 ± 2.12	6.11 ± 2.9^a	10.99 ± 2.09^a	9.00 ± 1.21	55.98 ± 2.43
ADM	4.63 ± 3.2	5.23 ± 2.12^a	10.78 ± 3.13^a	8.01 ± 1.22	54.01 ± 2.33
NS	13.21 ± 2.01^c	11.35 ± 2.09^c	29.55 ± 8.97^c	23.1 ± 1.83^c	56.67 ± 4.32
ADM + APS (50 mg/kg)	14.34 ± 1.78^c	12.11 ± 3.08^c	41.57 ± 6.42^a^c	29.97 ± 4.09^c	41.23 ± 3.12^a^c
ADM + APS (100 mg/kg)	25.31 ± 2.98^a^c	19.98 ± 3.21^a^c	38.82 ± 5.88^a^c	33.23 ± 3.99^a^c	27.23 ± 7.68^a^c
ADM + APS (200 mg/kg)	22.45 ± 4.01^a^c	26.67 ± 7.21^a^c	40.99 ± 5.54^a^c	44.78 ± 3.98^a^c	24.87 ± 5.78^a^c
ADM + VER	7.34 ± 2.11	5.77 ± 2.11	9.34 ± 1.75^a	9.11 ± 2.01	50.66 ± 1.12

^aP < 0.05 vs normal saline (NS) group;

^cP < 0.05 vs adriamycin (ADM) group. IL: Interleukin; TNF-α: Tumor necrosis factor-α; RFP: Rifampicin; APS: Astragalus polysaccharides; VER: Verapamil.

Table 3 Multidrug resistance 1 mRNA expression in tumor tissue (2^-∆∆Ct) (n = 10)

Group	2^-∆∆Ct ( mean ± SD )
ADM + RFP	5.02 ± 1.82
ADM	4.26 ± 1.51
NS	1.02 ± 0.05^a^c
ADM + APS (50 mg/kg)	0.48 ± 0.13^a^c
ADM + APS (100 mg/kg)	0.36 ± 0.03^a^c
ADM + APS (200 mg/kg)	0.21 ± 0.04^a^c
ADM + VER	0.28 ± 0.09^a^c

^aP < 0.05 vs adriamycin (ADM) group;

^cP < 0.05 vs ADM + rifampicin (RFP) group. NS: Normal saline; APS: Astragalus polysaccharides; VER: Verapamil.

Citation: Tian QE, Li HD, Yan M, Cai HL, Tan QY, Zhang WY. Astragalus polysaccharides can regulate cytokine and P-glycoprotein expression in H22 tumor-bearing mice. World J Gastroenterol 2012; 18(47): 7079-7086
URL: https://www.wjgnet.com/1007-9327/full/v18/i47/7079.htm
DOI: https://dx.doi.org/10.3748/wjg.v18.i47.7079