Connective tissue growth factor is overexpressed in human hepatocellular carcinoma and promotes cell invasion and growth

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Dec 21, 2012 (publication date) through Jan 29, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 21, 2012; 18(47): 7070-7078
Published online Dec 21, 2012. doi: 10.3748/wjg.v18.i47.7070

Table 1 Expression levels of transforming growth factor β1 or connective tissue growth factor mRNA in human hepatocellular carcinoma (mean ± SD)

	n	TGF-β1 mRNA (A)	CCN2 mRNA (A)
Normal control	6	6.24 ± 2.35	6.42 ± 2.35
Carcinoma foci	36	15.02 ± 4.43^b	12.36 ± 6.08^b
Stroma around carcinoma foci	36	47.56 ± 7.31^d	60.27 ± 28.71^d

^bP < 0.01 vs normal control;

^dP < 0.01 vs carcinoma foci. TGF-β1: Transforming growth factor β1; CCN2: Connective tissue growth factor.

Table 2 Effect of connective tissue growth factor on HepG2 cell cycle progression

^aP < 0.05 vs normal control. TGF-β1: Transforming growth factor β1; CCN2: Connective tissue growth factor.

Citation: Xiu M, Liu YH, Brigstock DR, He FH, Zhang RJ, Gao RP. Connective tissue growth factor is overexpressed in human hepatocellular carcinoma and promotes cell invasion and growth. World J Gastroenterol 2012; 18(47): 7070-7078
URL: https://www.wjgnet.com/1007-9327/full/v18/i47/7070.htm
DOI: https://dx.doi.org/10.3748/wjg.v18.i47.7070