Effects of hexahydrocurcumin in combination with 5-fluorouracil on dimethylhydrazine-induced colon cancer in rats

doi:10.3748/wjg.v18.i47.6951

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Dec 21, 2012 (publication date) through Nov 6, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 21, 2012; 18(47): 6951-6959
Published online Dec 21, 2012. doi: 10.3748/wjg.v18.i47.6951

Table 1 Effect of curcumin, hexahydrocurcumin, 5-fluorouracil and their combined treatment on aberrant crypt foci formation in rats exposed to dimethylhydrazine

Groups	Total ACF	Large ACF
Vehicle	1558.20 ± 17.37	262.20 ± 10.18
5-FU	1231.20 ± 25.62^b	111.00 ± 7.88^b
CUR	1284.20 ± 25.47^b	178.00 ± 7.33^b
HHC	1086.80 ± 53.47^b	186.60 ± 21.51^b
5-FU + CUR	880.20 ± 13.67^b^d^f	122.00 ± 5.94^b
5-FU + HHC	665.80 ± 16.64^b^d^h	119.00 ± 17.92^b^h

Each value is represented by mean ± SE.

^bP < 0.01 vs vehicle group;

^dP < 0.01 vs 5-fluorouracil (5-FU) monotherapy;

^fP < 0.01 vs curcumin (CUR) monotherapy;

^hP < 0.01 vs hexahydrocurcumin (HHC) monotherapy. ACF: Aberrant crypt foci.

Citation: Srimuangwong K, Tocharus C, Tocharus J, Suksamrarn A, Yoysungnoen Chintana P. Effects of hexahydrocurcumin in combination with 5-fluorouracil on dimethylhydrazine-induced colon cancer in rats. World J Gastroenterol 2012; 18(47): 6951-6959
URL: https://www.wjgnet.com/1007-9327/full/v18/i47/6951.htm
DOI: https://dx.doi.org/10.3748/wjg.v18.i47.6951