Oxymatrine liposome attenuates hepatic fibrosis via targeting hepatic stellate cells

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Aug 21, 2012 (publication date) through Dec 20, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 21, 2012; 18(31): 4199-4206
Published online Aug 21, 2012. doi: 10.3748/wjg.v18.i31.4199

Table 1 Serum level of alkaline phosphatase and ratio of collagen area to liver tissue in rats with CCl₄-induced hepatic fibrosis

Group	n	ALP (U/L)
Normal	10	73.91 ± 5.97
CCl₄-induced hepatic fibrosis	10	550.69 ± 43.80^e
OM-RGD liposomes	10	272.51 ± 19.55^a^c
OM liposomes	10	344.47 ± 27.52^c
RGD liposomes	10	562.78 ± 40.22
		Collagen area (%)
CCl₄-induced hepatic fibrosis	5	7.70 ± 0.60
RGD liposomes	5	8.32 ± 0.42
OM liposomes	5	2.36 ± 0.09^c
OM-RGD liposomes	5	0.26 ± 0.09^e

^aP < 0.05 vs normal;

^cP < 0.05 vs CCl₄-induced hepatic fibrosis group;

^eP < 0.05 vs oxymatrine (OM) liposomes. ALP: Alkaline phosphatase; RGD: Arg-Gly-Asp.

Citation: Chai NL, Fu Q, Shi H, Cai CH, Wan J, Xu SP, Wu BY. Oxymatrine liposome attenuates hepatic fibrosis via targeting hepatic stellate cells. World J Gastroenterol 2012; 18(31): 4199-4206
URL: https://www.wjgnet.com/1007-9327/full/v18/i31/4199.htm
DOI: https://dx.doi.org/10.3748/wjg.v18.i31.4199