Vitamin D deficiency: Correlation to interleukin-17, interleukin-23 and PIIINP in hepatitis C virus genotype 4

doi:10.3748/wjg.v18.i28.3738

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 18, Issue 28

This Article

Citation of this article

Corresponding Author of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (3433)

All Articles published online

The chart showing PDF series, HTML series, Figures (1-1) series, Tables (1-2) series.

Item

Count

PDF

272

HTML

2867

Figures (1-1)

155

Tables (1-2)

139

Sum=3433

Jul 28, 2012 (publication date) through May 6, 2024

Times Cited of This Article

Times Cited (19)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Brief Article

World J Gastroenterol. Jul 28, 2012; 18(28): 3738-3744
Published online Jul 28, 2012. doi: 10.3748/wjg.v18.i28.3738

Table 1 Levels of vitamin D, its active form, interleukin-17, interleukin-23, N-terminal propeptide of type III pro-collagen and viral load in the four subgroups of hepatitis C virus-infected patients

Item	Group (Ia)Bright hepatomegaly(n = 14)	Group (Ib)Perihepatic fibrosis(n = 11)	Group (Ic)Liver cirrhosis(n =11)	Group (Id)HCC(n = 14)	Group IINormal(n = 25)
Vit D (ng/mL)	19.80 ± 3.33^h	19.40 ± 3.52^h	10.90 ± 3.74^b^d^h	9.70 ± 3.88^b^d^h	39.70 ± 10.80
Active VitD (ng/mL)	20.60 ± 3.50^h	21.00 ± 3.44^h	13.00 ± 2.10^b^d^h	11.70 ± 2.52^b^d^h	41.90 ± 7.90
IL-17 (ng/mL)	7.60 ± 2.66^h	5.10 ± 2.44^h	115.90 ± 38.70^b^d^h	150.30 ± 46.80^b^d^f^h	1.20 ± 0.40
IL-23 (ng/mL)	76.80 ± 14.51^h	51.20 ± 14.60^h	259.30 ± 49.4^b^d^h	225.90 ± 42.10^b^d^h	6.70 ± 2.17
Viral load (IU/mL)	66.30 ± 23.55^h	42.40 ± 9.66^h	165.10 ± 31.40^b^d^h	231.10 ± 44.60^b^d^f^h	0 ± 0
PIIINP (μg/L)	91.03 ± 18.99^h	83.88 ± 28.77^h	209.09 ± 31.3^b^d^h	244.80 ± 34.10^b^d^f^h	22.61 ± 0.54

Values shown are means ± SD of data in four subgroups of hepatitis C virus-infected patients and normal controls. b, d, f, h means within lines with no common superscripts differ significantly. As compared with

^bgroup (Ia),

^dgroup (Ib),

^fgroup (Ic),

^hcontrol (group II) (one-way analysis of variance followed by Tukey-Kramer test), P < 0.01. HCC: Hepatocellular carcinoma; IL: Interleukin.

Table 2 Vitamin D, its active form, interleukin-17, interleukin-23, N-terminal propeptide of type III pro-collagen and viral load in male and female subgroups of hepatitis C virus-infected patients

Item	Male group(n = 36)	Female group(n = 14)	P value
Vit D (ng/mL)	10.30 ± 2.12	10.00 ± 2.60	1.00
Active Vit D (ng/mL)	12.10 ± 2.80	12.40 ± 2.60	0.96
Viral load (IU/mL)	198.00 ± 38.10	199.00 ± 31.10	0.93
IL-17 (ng/mL)	133.80 ± 32.50	134.90 ± 32.60	0.90
IL-23 (ng/mL)	241.00 ± 28.10	243.00 ± 26.50	0.92
PIIINP (μg/L)	226.57 ± 346.54	227.94 ± 36.45	0.90

Values shown are means ± SD of data for both male and female hepatitis C virus-infected subjects. Values shown include group Ic (liver cirrhosis) and Id (hepatocellular carcinoma) subjects. Significant difference is determined at P < 0.05. IL: Interleukin; Vit: Vitamin.

Citation: Schaalan MF, Mohamed WA, Amin HH. Vitamin D deficiency: Correlation to interleukin-17, interleukin-23 and PIIINP in hepatitis C virus genotype 4. World J Gastroenterol 2012; 18(28): 3738-3744
URL: https://www.wjgnet.com/1007-9327/full/v18/i28/3738.htm
DOI: https://dx.doi.org/10.3748/wjg.v18.i28.3738