Law ST, Li KK. Is hepatic neoplasm-related pyogenic liver abscess a distinct clinical entity? World J Gastroenterol 2012; 18(10): 1110-1116 [PMID: 22416187 DOI: 10.3748/wjg.v18.i10.1110]
Corresponding Author of This Article
Siu-Tong Law, MBBS, FHKCP, FHKAM, Division of Gastroenterology and Hepatology, Department of Medicine and Geriatrics, Tuen Mun Hospital, Hong Kong, China. stl168@hotmail.com
Article-Type of This Article
Brief Article
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World J Gastroenterol. Mar 14, 2012; 18(10): 1110-1116 Published online Mar 14, 2012. doi: 10.3748/wjg.v18.i10.1110
Table 1 Demographic and clinical characteristics of patients with/without hepatic neoplasm-associated pyogenic liver abscess (mean ± SD) n (%)
Variable
HN group(n = 35)
Non-HN group(n = 283)
P value
Age (yr)
67.7 ± 16.2
65.4 ± 15.13
0.40
Sex (male: female)
18:17
163:120
Comorbidity
Diabetes mellitus
9 (25.7)
81 (28.6)
0.36
Hypertension
12 (34.3)
78 (27.6)
0.20
Ischemic heart disease
1 (2.9)
23 (8.1)
0.14
Stroke
2 (5.7)
31 (11.0)
0.17
Duration of symptoms before presentation (d)
3.7 ± 2.8
4.9 ± 4.9
0.18
Symptoms and signs
Fever and chill
34 (97.1)
268 (94.7)
0.27
Right upper quadrant pain
24 (68.6)
149 (52.7)
< 0.04
Diarrhea
1 (2.9)
21 (7.5)
0.16
Cough and sputum
6 (17.1)
59 (20.8)
0.41
Jaundice
5 (14.3)
16 (5.7)
< 0.03
Hepatomegaly
6 (17.1)
11 (3.9)
< 0.01
Right pleural effusion/ consolidation (on admission)
3 (8.6)
39 (13.8)
0.20
Table 2 Laboratory findings and radiological features of patients with/without hepatic neoplasm-associated pyogenic liver abscess n (%)
Laboratory parameters
HN group(n = 35)
Non-HN group(n = 283)
P value
Hemoglobin (mean, g/dL)
10.0
11.3
0.22
White cell count (mean, 109/L)
18.9
16.8
0.13
ESR (mean, mm/h)
82.0
78.9
0.84
CRP (mean, mg/L)
120.0
141.8
0.56
Albumin (mean, g/L)
27.1
29.6
0.56
Total bilirubin (mean, mol/L)
43.3
30.0
0.05
Alanine aminotransferase (mean, U/L)
64.1
84.1
0.16
Hba1c (mean, %)
10.3
9.1
0.41
Bacteremia
13 (37.1)
120 (42.4)
0.27
Radiological features
Size (cm, mean ± SD)
6.8 ± 3.1
6.1 ± 3.0
0.19
Site
Right lobe
22 (62.9)
156 (55.1)
0.19
Solitary/multiple
15 (43)/ 7 (20)
133 (47)/ 23 (8.1)
Left lobe
7 (20)
82 (29)
0.13
Solitary/multiple
5 (14.3)/ 2 (5.7)
73 (25.8)/ 9 (3.2)
Bilobar
3 (8.6)
37 (13.1)
0.22
Echogenicity
Hypoechoic
31 (88.6)
256 (90.5)
0.36
Hyperechoic/heterogenous
4 (11.4)
27 (9.5)
0.37
Thicken wall
13 (37.1)
55 (19.4)
< 0.01
Rim enhancement
26 (74.3)
176 (62.2)
0.08
Septal lobulation
27 (77.1)
164 (58.0)
< 0.02
Aerobilia
7 (25.9)
16 (5.5)
< 0.01
Fluid/gaseous cavitation
33 (94.3)/ 6 (17.1)
243 (85.9)/ 21 (7.8)
0.08/ 0.03
Portal thrombophlebitis
4 (11.4)
5 (1.8)
< 0.01
Subcapsular rupture of the abscess
2 (5.7)
16 (5.6)
0.49
Table 3 Bacteriology, pathogenesis and confirmatory investigations of hepatic neoplasm- and non-hepatic neoplasm-associated pyogenic liver abscess n (%)