Hepatic steatosis prevents heme oxygenase-1 induction by isoflurane in the rat liver

Table 1 Time course of mean arterial pressure, heart rate and temperature

	Time (h)	LEAN+PEN	LEAN+ISO	FAT+PEN	FAT+ISO
MAP	0	127a± 5	82 ± 11	106 ± 5	99 ± 5
(mmHg)	2	86a± 3	72 ± 2	77 ± 4	73 ± 2
	4	85a± 5	69 ± 2	74 ± 4	69 ± 2
	6	84a± 7	69 ± 2	72 ± 3	70 ± 2
HR	0	305 ± 3	302 ± 4	314 ± 2	310 ± 2
(bpm)	2	302 ± 2	300 ± 0	319 ± 3	312 ± 0
	4	310 ± 2	305 ± 3	310 ± 2	310 ± 4
	6	307 ± 3	307 ± 3	310 ± 2	310 ± 2
Temp.	0	34.4c± 0.3	34.7c± 0.6	34.5c± 0.2	34.7c± 0.3
(°C)	2	36.6 ± 0.3	37.2 ± 0.3	36.6 ± 0.3	36.9 ± 0.1
	4	37.1 ± 0.2	37.5 ± 0.1	37.2 ± 0.1	37.0 ± 0.2
	6	37.1 ± 0.2	37.5 ± 0.0	37.2 ± 0.1	37.0 ± 0.1

Data are presented as mean ± SE of the mean for n = 5 animals per group.

^aP < 0.05 vs all other groups,

^cP < 0.05 vs all other time points. MAP: Mean arterial pressure; HR: Heart rate; Temp.: Temperature; LEAN: Lean Zucker rats; FAT: Obese Zucker rats; ISO: Isoflurane; PEN: Pentobarbital sodium.

Table 2 Body weight and baseline values of blood gas parameters

	LEAN+PEN	LEAN+ISO	FAT+PEN	FAT+ISO
Weight (g)	321 ± 19	294 ± 16	462b± 14	426b± 18
pH	7.46 ± 0.03	7.48 ± 0.03	7.48 ± 0.04	7.42 ± 0.01
pCO2 (mmHg)	40 ± 3	37 ± 3	32 ± 4	33 ± 4
pO2 (mmHg)	211 ± 52	279 ± 69	258 ± 33	308 ± 74

Data were obtained after induction of anesthesia. Data are presented as mean ± SE of the mean for n = 5 animals per group (^bP < 0.001 vs Lean + Pentobarbital sodium and Lean + Isoflurane). pCO₂: Arterial carbon dioxide partial pressure; pO₂ : Arterial oxygen partial pressure; LEAN: Lean Zucker rats; FAT: Obese Zucker rats; ISO: Isoflurane; PEN: Pentobarbital sodium.