Influence of irritable bowel syndrome on treatment outcome in gastroesophageal reflux disease

Table 1 Demographic data and baseline characteristics [intention-to-treat population, number of patients (n) = 1888]

Age (yr), mean (SD)	47 (14.3)
Height (cm), mean (SD)	167.5 (9.6)
Weight (kg), mean (SD)	74.2 (15.8)
BMI (kg/m2), mean (SD)	26.4 (4.8)
Gender, n (%)
Female	978 (51.8)
Male	910 (48.2)
Esophagitis, n (%)
Non-erosive	694 (36.8)
Grade A	680 (36.0)
Grade B	381 (20.2)
Grade C	97 (5.1)
Grade D	23 (1.2)
Ethnic origin, n (%)
White	1326 (70.2)
Asian	352 (18.6)
Other	167 (8.8)
Black	43 (2.3)
Smoker, n (%)
Never	1179 (62.4)
Former	360 (19.1)
Current	349 (18.5)

BMI: Body mass index.

Table 2 Pre-post differences of “acid complaints” and “lower abdominal complaints” in erosive and non-erosive reflux disease patients with and without irritable bowel syndrome-like symptoms after 4 and 8 wk

	ERD		NERD
	IBS-like +	IBS-like -	IBS-like +	IBS-like -
Acid complaints
4 wk	1.6	1.6	1.6	1.4
8 wk	1.6	1.7	1.7	1.6
Lower abdominal complaints
4 wk	0.7	0.7	1.0a	0.7
8 wk	1.0	0.8	1.2b	0.8

^aP = 0.049 irritable bowel syndrome (IBS)-like + vs IBS-like -;

^bP = 0.0092 IBS-like + vs IBS-like -. ERD/NERD: Erosive/non-erosive reflux disease.