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©2011 Baishideng Publishing Group Co.
World J Gastroenterol. Jun 21, 2011; 17(23): 2867-2872
Published online Jun 21, 2011. doi: 10.3748/wjg.v17.i23.2867
Published online Jun 21, 2011. doi: 10.3748/wjg.v17.i23.2867
Table 1 Clinicopathological characteristics of 3018 gastric cancers included in the study n (%)
Variable | Subgroups | Frequency |
Gender ratio | Male | 2211 (73.26) |
Female | 807 (26.74) | |
Age at diagnosis (mean ± SD; yr) | 57.54 ± 11.24 | |
Past history | ||
Without | 2234 (74.02) | |
With | 784 (25.98) | |
Family history | Without | 2467 (81.74) |
With | 551 (18.26) | |
Cancer number | Single | 2883 (96.65) |
Multiple | 100 (3.35) | |
Cancer location | Lower stomach | 1873 (62.64) |
Middle stomach | 492 (16.46) | |
Upper stomach | 355 (11.87) | |
Total stomach | 270 (9.03) | |
Distant metastasis status | Without | 2540 (85.04) |
With | 447 (14.96) | |
Maximum tumor diameter (mean ± SD, cm) | 5.85 ± 3.30 | |
Surgical curative degree | Absolutely radical | 1396 (49.73) |
Relatively radical | 809 (28.82) | |
Palliative | 602 (21.45) | |
Lymph node dissection | More than D2 | 608 (20.99) |
D2 | 1362 (47.03) | |
D1 | 269 (9.29) | |
Palliative surgery | 657 (22.69) | |
Combined other organ resection | Without | 2016 (76.80) |
With | 609 (23.20) | |
Histological type | Well differentiated | 755 (27.43) |
Middle differentiated | 382 (13.88) | |
Poor differentiated | 1615 (58.69) | |
Borrmann classification | I | 70 (2.98) |
II | 426 (18.15) | |
III | 1571 (66.94) | |
IV | 280 (11.93) | |
Lauren classification | Intestinal type | 1170 (43.89) |
Diffuse type | 1496 (56.11) | |
pT stage | pT1 | 328 (11.89) |
pT2 | 1486 (53.88) | |
pT3 | 737 (26.72) | |
pT4 | 207 (7.51) | |
Total dissected lymph node (mean ± SD) | 15.27 ± 13.11 | |
Pathological lymph node status | pN0 | 1375 (45.56) |
pN1 | 1039 (34.43) | |
pN2 | 432 (14.31) | |
pN3 | 172 (5.70) |
Table 2 Univariate model of Cox and log normal regression with prognostic factors
HR (95% CI) | ||||
Cox | Log normal | |||
Sex | ||||
Male | 0.953 (0.843-1.078) | 0.925 (0.818-1.046) | ||
Female | 1.00 | 1.00 | ||
Age at diagnosis | 1.0151 (1.009-1.020) | 1.0161 (1.011-1.021) | ||
Past history | ||||
Without | 1.00 | 1.00 | ||
With | 0.7151 (0.631-0.831) | 0.6941 (0.612-0.787) | ||
Family history | ||||
Without | 1.00 | 1.00 | ||
With | 0.871 (0.752-1.009) | 0.875 (0.754-1.014) | ||
Cancer number | ||||
Single | 1.00 | 1.00 | ||
Multiple | 0.870 (0.622-1.218) | 0.924 (0.661-1.294) | ||
Cancer location | ||||
Lower third | 1.00 | 1.00 | ||
Middle third | 1.1811 (1.017-1.373) | 1.3021 (1.233-1.374) | ||
Upper third | 1.4361 (1.212-1.701) | 1.6951 (1.429-1.897) | ||
Total stomach | 2.4641 (2.062-2.944) | 2.2071 (2.011-2.677) | ||
Distant metastasis | ||||
Absent | 1.00 | 1.00 | ||
Present | 2.5541 (2.194-2.973) | 2.5961 (2.227-3.027) | ||
Surgical curative degree | ||||
Absolutely radical | 1.00 | 1.00 | ||
Relatively radical | 1.8351 (1.593-2.114) | 2.1591 (2.020-2.308) | ||
Palliative | 4.2361 (3.714-4.832) | 4.6611 (4.214-4.759) | ||
Lymph node dissection | ||||
> D2 | 1.00 | 1.00 | ||
D2 | 0.989 (0.859-1.138) | 1.5361 (1.458-1.619) | ||
D1 | 1.056 (0.853-1.307) | 2.3591 (2.121-2.574) | ||
< D1 | 3.3101 (2.854-3.839) | 3.6241 (3.231-3.862) | ||
Combined other organ resection | ||||
Without | 1.00 | 1.00 | ||
With | 1.9811 (1.749-2.245) | 2.0701 (1.825-2.348) | ||
Histologic types | ||||
Well differentiated | 1.00 | 1.00 | ||
Middle differentiated | 0.7061 (0.592-0.843) | 0.976 (0.918-1.039) | ||
Poor differentiated | 0.918 (0.814-1.036) | 0.952 (0.897-1.011) | ||
Borrmann classification (n (%)) | ||||
I | 1.00 | 1.00 | ||
II | 1.005 (0.892-1.340) | 0.981 (0.894-1.019) | ||
III | 1.2471 (1.173-1.638) | 1.1761 (1.074-1.293) | ||
IV | 2.5121 (1.842-3.075) | 2.6101 (2.416-3.153) | ||
Lauren classification (n (%)) | ||||
Intestinal type | 1.00 | 1.00 | ||
Diffuse type | 1.2451 (1.082-1.184) | 1.1711 (1.015-1.384) | ||
pT stage | ||||
pT1 | 1.00 | 1.00 | ||
pT2 | 2.9361 (2.299-3.751) | 1.7871 (1.666-1.916) | ||
pT3 | 4.3051 (3.357-5.522) | 3.1931 (3.066-3.321) | ||
pT4 | 7.6971 (5.759-10.287) | 5.7071 (5.579-5.833) | ||
Total dissected nodes | 0.9931 (0.988-0.998) | 0.9941 (0.988-0.998) | ||
pN stage | ||||
pN0 | 1.00 | 1.00 | ||
pN1 | 1.5551 (1.372-1.764) | 1.6331 (1.533-1.740) | ||
pN2 | 2.5101 (2.133-2.953) | 2.6671 (2.561-2.772) | ||
pN3 | 3.6691 (2.901-4.640) | 4.3551 (4.249-4.460) |
Table 3 Multivariate model of Cox and log normal regression with prognostic factors (full model and final model)
Cox HR (95% CI) | Log normal HR (95% CI) | |||
Full model (AIC = 1508.49) | Final model (AIC = 2534.72) | Full model (AIC = 913.34) | Final model (AIC = 1693.56) | |
Sex | ||||
Male | 0.91 (0.801-1.034) | 0.886 (0.781-1.005) | ||
Female | 1.00 | |||
Age at diagnosis | 1.0141 (1.009-1.02) | 1.0111 (1.006-1.017) | 1.0151 (1.010-1.021) | 1.0151 (1.009-1.020) |
Past history | ||||
Without | 1.00 | 1.00 | 1.00 | 1.00 |
With | 0.8401 (0.738-0.955) | 0.8581 (0.755-0.975) | 0.8131 (0.716-0.914) | 0.8091 (0.713-0.919) |
Family history | ||||
Without | 1.00 | 1.00 | 1.00 | |
With | 0.957 (0.8254-1.11) | 0.967 (0.833-1.234) | ||
Cancer number | ||||
Single | 1.00 | 1.00 | ||
Multiple | 1.21 (0.861-1.701) | 1.312 (1.935-1.840) | ||
Cancer location | ||||
Lower third | 1.00 | 1.00 | 1.00 | |
Middle third | 1.033 (0.885-1.205) | 1.1351 (1.073-1.199) | 1.1291 (1.069-1.194) | |
Upper third | 1.4061 (1.173-1.686) | 1.2881 (1.224-1.353) | 1.2771 (1.211-1.338) | |
Total stomach | 1.4661 (1.214-1.771) | 1.4621 (1.365-1.558) | 1.4391 (1.343-1.535) | |
Distant metastasis | ||||
Absent | 1.00 | 1.00 | 1.00 | |
Present | 1.211 (1.013-1.447) | 1.2051 (1.011-1.437) | 1.1981 (1.009-1.424) | |
Surgical curative degree | ||||
Absolutely radical | 1.00 | 1.00 | 1.00 | 1.00 |
Relatively radical | 1.3891 (1.197-1.611) | 1.3831 (1.194-1.601) | 1.7241 (1.537-1.934) | 1.6721 (1.538-1.817) |
Palliative | 3.8891 (2.583-5.855) | 2.6871 (2.316-3.116) | 2.9721 (2.770-3.174) | 2.7961 (2.653-2.938) |
Lymph node dissection | ||||
> D2 | 1.00 | 1.00 | ||
D2 | 0.908 (0.784-1.051) | 0.967 (0.892-1.049) | ||
D1 | 0.901 (0.712-1.14) | 0.935 (0.855-1.015) | ||
< D1 | 0.6071 (0.395-0.935) | 0.904 (0.784-1.024) | ||
Combined other organ resection | ||||
Without | 1.00 | 1.00 | ||
With | 1.4061 (1.227-1.61) | 1.4471 (1.264-1.657) | ||
Histologic types | ||||
Well differentiated | 1.00 | 1.00 | 1.00 | |
Middle differentiated | 1.056 (0.878-1.271) | 1.1101 (1.042-1.183) | 1.1201 (1.051-1.193) | |
Poor differentiated | 1.1791 (1.035-1.343) | 1.2321 (1.160-1.304) | 1.2541 (1.182-1.327) | |
Borrmann classification | ||||
I | 1.00 | 1.00 | 1.00 | 1.00 |
II | 1.142 (0.957-1.319) | 1.201 (1.068-1.433) | 1.018 (0.943-1.106) | 1.015 (0.941-1.102) |
III | 1.3151 (1.113-1.672) | 1.3941 (1.205-1.741) | 1.2461 (1.052-1.539) | 1.2411 (1.047-1.533) |
IV | 2.1261 (1.758-3.119) | 2.2531 (1.827-3.284) | 2.5301 (2.376-2.713) | 2.5261 (2.372-2.708) |
Lauren classification | ||||
Intestinal type | 1.00 | 1.00 | 1.00 | |
Diffuse type | 1.1311 (1.012-1.358) | 1.3071 (1.154-1.528) | 1.3021 (1.148-1.523) | |
pT stage | ||||
pT1 | 1.00 | 1.00 | 1.00 | 1.00 |
pT2 | 1.8511 (1.431-2.394) | 1.9711 (1.528-2.542) | 1.1951 (1.102-1.297) | 1.1931 (1.100-1.294) |
pT3 | 1.9811 (1.511-2.598) | 2.191 (1.678-2.858) | 1.4281 (1.328-1.527) | 1.4231 (1.324-1.522) |
pT4 | 2.3441 (1.699-3.235) | 2.5011 (1.821-3.435) | 1.7061 (1.557-1.855) | 1.6971 (1.549-1.847) |
Total dissected nodes | 0.9871 (0.981-0.993) | 0.9881 (0.982-0.993) | ||
pN stage | ||||
pN0 | 1.00 | 1.00 | 1.00 | 1.00 |
pN1 | 1.2811 (1.123-1.461) | 1.2661 (1.11-1.444) | 1.5071 (1.393-1.620) | 1.5001 (1.387-1.622) |
pN2 | 2.1391 (1.783-2.566) | 2.0951 (1.749-2.51) | 2.2711 (2.151-2.391) | 2.2501 (2.130-2.370) |
pN3 | 3.241 (2.446-4.292) | 3.3251 (2.52-4.386) | 3.4221 (3.242-3.602) | 3.3751 (3.196-3.554) |
- Citation: Wang BB, Liu CG, Lu P, Latengbaolide A, Lu Y. Log-normal censored regression model detecting prognostic factors in gastric cancer: A study of 3018 cases. World J Gastroenterol 2011; 17(23): 2867-2872
- URL: https://www.wjgnet.com/1007-9327/full/v17/i23/2867.htm
- DOI: https://dx.doi.org/10.3748/wjg.v17.i23.2867