p53 antibodies, metallothioneins, and oxidative stress markers in chronic ulcerative colitis with dysplasia

doi:10.3748/wjg.v17.i19.2417

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May 21, 2011 (publication date) through Nov 2, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. May 21, 2011; 17(19): 2417-2423
Published online May 21, 2011. doi: 10.3748/wjg.v17.i19.2417

Table 1 Demographic and biochemical characteristics in all studied groups (mean ± SD)

	Group I (n = 15)	Group II(n = 15)	Group III(n = 15)
Age (yr)	40.3 ± 14.6	52.9 ± 17.8	65.5 ± 11.2
Sex (male/female)	8/7	9/6	7/8
Disease duration (yr)	------	6 ± 1.1	7 ± 2.1
TG (mg/dL)	90.3 ± 14.5	92.0 ± 10.8	96.5 ± 10.8
TC (mg/dL)	160.5 ± 13.76	167.6 ± 15.3	170.5 ± 13.8
LDL-C (mg/dL)	124 ± 16.46	142.33 ± 24.41	142.66 ± 24.33
HDL-C (mg/dL)	54.50 ± 11.81	44.06 ± 9.12	41.60 ± 10.85
Hb (g/dL)	13.1 ± 1	11.78 ± 1.2	11.3 ± 0.9
WBC (/mm³)	5180 ± 967	5630 ± 1252	5033.3 ± 976
PLT (10⁴/mm³)	34.8 ± 5	36 ± 4.9	38 ±4.2
Albumin (g/dL)	4.1 ± 0.23	4.08 ± 0.35	2.9 ± 0.29

Group I: Control group; Group II: Ulcerative colitis without dysplasia; Group III: Ulcerative colitis with dysplasia; TG: Triglyceride; TC: Total cholesterol; HDL-C: High density lipoprotein-cholesterol; LDL-C: Low density lipoprotein-cholesterol; Hb: Hemoglobin; WBC: White blood cell count; PLT: Platelet count. P > 0.05 are presented as not significant.

Table 2 Statistical comparison between all studied parameters in all studied groups (mean ± SD)

	Group I (n = 15)	Group II(n = 15)	Group III(n = 15)	P
AOPP (μmol/L)	128.95 ± 3.06	145.94 ± 29.86	192.21 ± 46.71	< 0.002¹^a
				< 0.001¹^b
				< 0.001¹^c
GSH (μmol/L)	2.49 ± 0.10	1.87 ± 0.02	1.37 ± 0.09	< 0.05¹^a
				< 0.05¹^b
				< 0.05¹^c
MT (μg/mL)	6.12 ± 0.25	8.18 ± 0.35	9.20 ± 0.58	< 0.05¹^a
				< 0.05¹^b
				> 0.096^c
p53Abs (U/mL)	9.42 ± 1.64	20.19 ± 3.20	34.66 ± 1.34	< 0.001¹^a
				< 0.001¹^b
				< 0.001¹^c

¹Significant;

^aGroup II vs group I;

^bGroup III vs group I;

^cGroup III vs group II. AOPP: Advanced oxidation protein product; GSH: Glutathione; MT: Metallothionein; p53Abs: p53 antibodies.

Table 3 Correlation matrix between all studied parameters

	r	P
AOPP (μmol/L) and GSH (μmol/mL)	-0.385	0.001¹
AOPP (μmol/L) and MT (μg/mL)	0.678	0.001¹
AOPP (μmol/L) and p53Abs (U/mL)	0.547	0.001¹
GSH (μmol/L) and MTs (μg/mL)	-0.662	0.001¹
GSH (μmol/L) and p53Abs (U/mL)	-0.923	0.001¹
p53Abs (U/mL) and MT (μg/mL)	0.739	0.001¹

¹Significant. AOPP: Advanced oxidation protein product; GSH: Glutathione; MT: Metallothionein; p53Abs: p53 antibodies.

Citation: Hamouda HE, Zakaria SS, Ismail SA, Khedr MA, Mayah WW. p53 antibodies, metallothioneins, and oxidative stress markers in chronic ulcerative colitis with dysplasia. World J Gastroenterol 2011; 17(19): 2417-2423
URL: https://www.wjgnet.com/1007-9327/full/v17/i19/2417.htm
DOI: https://dx.doi.org/10.3748/wjg.v17.i19.2417