Predictive factors of clinical response in steroid-refractory ulcerative colitis treated with granulocyte-monocyte apheresis

Table 1 Characteristics of granulocyte-monocyte apheresis treated patients: Demographic and clinical data

Sex	F/M	39/30
Age (yr)	mean (range)	42.36 (27-75)
Duration of disease (mo)	mean (range)	41.34 (12-262)
Location of disease	Left side/pancolitis	47/22
Steroid course	Dependent/resistant	49/20
CAI	mean (range)	9.10 (6-13)
ESR (mm/h)	mean (range)	33.09 (2-20)
CRP (mg/dL)	mean (range)	2.04 (0.3-7.3)
WBC 103	mean (range)	10.69 (5.7-14)

CAI: Clinical activity index; ESR: Erythrocyte sedimentation rate; CRP: C reactive protein; WBC: White blood cell.

Table 2 Univariate analysis of predictive factors of clinical response to granulocyte-monocyte apheresis: Age, White blood cells, erythrocyte sedimentation rate and clinical activity index score, C reactive protein, location duration of disease at baseline and use of immunosuppressant (mean ± SD)

	Responders (n = 40)	Non responders (n = 29)	P-value
Age (yr)	42.7 ± 13.8	41.9 ± 6.6	0.774
WBC 103	10.2 ± 2.7	11.2 ± 2.2	0.106
ESR (mm/h)	30.6 ± 13.5	38.4 ± 12.5	0.017
CAI	8.6 ± 2.1	9.7 ± 2.2	0.039
CRP (mg/dL)	1.2 ± 1.2	1.4 ± 1.4	0.526
Location of disease (left side/pancolitis)	28/12	19/10	0.795
Duration of disease (yr)	11	6	0.581
Use of immunosuppressant	5	15	0.601

CAI: Clinical activity index; ESR: Erythrocyte sedimentation rate; CRP: C reactive protein; WBC: White blood cells.

Table 3 Multivariate analysis of predictive factors of clinical response to granulocyte-monocyte apheresis: Steroid course and clinical activity index score at baseline

Independent variables	OR	95% CI	Wald	P-value
Steroid course	0.390	0.176-0.865	5.361	0.016
4 < CAI < 8	0.770	0.425-1.394	3.747	0.028
CRP (mg/dL)	0.908	0.381-2.166	0.047	0.828
ESR (mm/h)	0.965	0.491-1.896	0.011	0.917
Location of disease (Left side/pancolitis)	0.822	0.462-1.462	0.446	0.504
Duration of disease > 120 mo	1.089	0.485-2.466	0.043	0.836

CAI: Clinical activity index; ESR: Erythrocyte sedimentation rate; CRP: C reactive protein; OR: Odds ratio; CI: Confidence interval.