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©2011 Baishideng Publishing Group Co.
World J Gastroenterol. Mar 14, 2011; 17(10): 1267-1275
Published online Mar 14, 2011. doi: 10.3748/wjg.v17.i10.1267
Published online Mar 14, 2011. doi: 10.3748/wjg.v17.i10.1267
Table 1 Patient and tumor criteria (n)
Total number | 39 |
Age (yr) | Range: 45-79, mean: 66.4, SD: 7 |
Gender (M:F) | 33:6 |
Underlying liver pathology | |
Hepatitis C virus | 17 |
Hepatitis B virus | 5 |
Alcoholic cirrhosis | 7 |
Toxic cirrhosis | 2 |
Cryptogenic cirrhosis | 8 |
Child-Pugh Score | |
Child A | 27 |
Child B | 12 |
Tumor number | |
Solitary | 20 |
Multiple | 19 |
2 lesions | 6 |
3 lesions | 3 |
4 lesions | 1 |
> 5 lesions | 9 |
Tumor margin definition | |
Well defined margin | 20 |
Ill defined margin | 19 |
Portal vein thrombosis | 19 |
Main (partial thrombosis) | 3 |
Main lobar branch | 10 |
Segmental branch | 6 |
A-P shunt | 7 |
Table 2 Response evaluation criteria in solid tumors in different patient groups n (%)
Total | B | APS | Child A | Child B | Solitary | Multiple | Well defined | Ill defined | |||
Yes | No | Yes | No | ||||||||
No. of patients | 39 | 19 | 20 | 7 | 32 | 27 | 12 | 20 | 19 | 20 | 19 |
Partial response | 1 (2.6) | 0 | 1 (5) | 0 | 1 (3.1) | 0 | 1 (8.3) | 0 | 1 (5.2) | 1 (5) | 0 |
Stable disease | 34 (87.1) | 18 (94.7) | 16 (80) | 6 (85.7) | 28 (87.5) | 24 (88.9) | 10 (83.3) | 18 (90) | 16 (84.2) | 17 (85) | 17 (89.4) |
Progressive disease | 4 (10.3) | 1 (5.3) | 3 (15) | 1 (14.2) | 3 (9.30) | 3 (11.1) | 1 (8.3) | 2 (10) | 2 (10.5) | 2 (10) | 2 (10.5) |
Table 3 Magnetic resonance imaging volumetric changes of tumors after transarterial chemoembolization in different patient groups
Total | PVT | APS | Child A | Child B | Solitary | Multiple | Well defined | Ill defined | |||
Yes | No | Yes | No | ||||||||
No. of patients | 39 | 19 | 20 | 7 | 32 | 27 | 12 | 20 | 19 | 20 | 19 |
Initial tumor volume (mL) | |||||||||||
Range | 1.2-1358 | 1.2-1358 | 28.8-301.9 | 28.9-237 | 1.2-1358 | 1.1-1355 | 56.7-1358 | 1.2-1355 | 23.4-1358 | 1.2-301.9 | 28.8-1358 |
Mean | 227.6 | 354.5 | 107 | 109.2 | 253.5 | 162.3 | 374.5 | 246 | 208.2 | 97.0 | 365 |
SD | 318.76 | 418.2 | 78.5 | 75.2 | 345.8 | 275.8 | 370.5 | 317 | 327.2 | 60.0 | 411 |
Tumor volume 1 mo after the 1st TACE | |||||||||||
Range | 1.3-1637.5 | 1.3-1637.5 | 15.6-334.8 | 39-239 | 1.3-637.5 | 1.3-1500 | 23.7-1637.5 | 1.3-1499.7 | 15.6-1637.5 | 1.3-334.9 | 39-1637.5 |
Mean | 244.5 | 402.6 | 94.3 | 126.5 | 270.3 | 159.6 | 435.6 | 242.6 | 246.6 | 65.3 | 412 |
SD | 369 | 480.1 | 72.8 | 85.0 | 402.2 | 284.7 | 470.0 | 334.3 | 411.9 | 75.3 | 473 |
Tumor volume at the end of treatment | |||||||||||
Range | 1.6- 2053.4 | 1.6-2053.4 | 9.4-403.1 | 94.5-308 | 1.6-2053.4 | 1.6-2053.4 | 22.5-1637.5 | 1.6-2053.4 | 9.4-1637.4 | 1.6-403.1 | 83-2053.4 |
Mean | 286.1 | 486 | 96.2 | 188.6 | 307.5 | 197.4 | 485.6 | 280.8 | 291.7 | 74.3 | 509.1 |
SD | 453.2 | 583.7 | 100 | 72.5 | 490 | 391 | 534.2 | 452.9 | 465.8 | 69.5 | 568 |
Table 4 Local tumor response using volumetric magnetic resonance imaging analysis n (%)
Total | PVT | APS | Child A | Child B | Solitary | Multiple | Well defined | Ill defined | |||
Yes | No | Yes | No | ||||||||
No. of patients | 39 | 19 | 20 | 7 | 32 | 27 | 12 | 20 | 19 | 20 | 19 |
Tumor volume reduction after last TACE session | 17 (43.6) | 5 (26.3) | 12 (60) | 0 (0) | 17 (53.1) | 13 (48.1) | 4 (33.3) | 9 (45) | 8 (42.1) | 13 (65) | 4 (21.05) |
Tumor volume progression after last TACE session | 22 (56.4) | 14 (73.7) | 8 (40) | 7 (100) | 15 (46.9) | 14 (51.9) | 8 (66.7) | 11 (55) | 11 (57.9) | 7 (35) | 15 (78.9) |
- Citation: Vogl TJ, Nour-Eldin NE, Emad-Eldin S, Naguib NN, Trojan J, Ackermann H, Abdelaziz O. Portal vein thrombosis and arterioportal shunts: Effects on tumor response after chemoembolization of hepatocellular carcinoma. World J Gastroenterol 2011; 17(10): 1267-1275
- URL: https://www.wjgnet.com/1007-9327/full/v17/i10/1267.htm
- DOI: https://dx.doi.org/10.3748/wjg.v17.i10.1267