Effects of meal size and proximal-distal segmentation on gastric activity

Table 1 Effect of meal volume and proximal-distal segmentation in intragastric distribution parameters (mean ± SE)

	60 mL			180 mL
	ROIs 1	ROIs 2	ROIs 3	ROIs 1	ROIs 2	ROIs 3
Total stomach
Initial retention	100	100	100	100	100	100
Final retention	82.5 ± 3.8	83.5 ± 3.2	83.8 ± 2.9	84.9 ± 3.3	85.7 ± 3.1	85.5 ± 3.2
Proximal (%)
Initial retention	39.8 ± 6.8	51.7 ± 6.0	73.2 ± 3.8a.c	38.6 ± 6.4	52.3 ± 6.4	75.2 ± 4.3a.c
Final retention	14.1 ± 2.5	22.8 ± 3.0	41.6 ± 3.7a.c	27.7 ± 5.7e	38.3 ± 5.5g	60.4 ± 4.2a.c,i
T1/2 (min)	4.2 ± 0.6	7.0 ± 0.8	> 18.0	11.0 ± 2.2	> 18.0	> 18.0
Distal (%)
Initial retention	60.1 ± 6.7	48.1 ± 6.0	26.6 ± 3.8a.c	61.4 ± 6.4	47.6 ± 6.4	24.7 ± 4.3a.c
Final retention	68.4 ± 4.0	60.7 ± 3.2	42.2 ± 4.0a.c	57.1 ± 4.2	47.6 ± 4.5g	25.1 ± 2.5a.c,i
Maximum content	80.0 ± 4.5	69.0 ± 3.7	48.0 ± 3.6a.c	69.0 ± 5.0	56.7 ± 5.7	32.0 ± 3.8a.c

^aP < 0.05 vs ROIs 1; ^cP < 0.05 vs ROIs 2;

^eP < 0.04 vs 60 mL;

^gP < 0.03 vs 60 mL; ⁱP < 0.003 vs 60 mL. ROIs: Regions of interest.

Table 2 Mean area under the curve and time distribution by statistical moments for proximal and distal regions for the three proximal-distal segmentations, after ingestion of the test meal of 60 and 180 mL (mean ± SE)

	Proximal			Distal
	ROIs 1	ROIs 2	ROIs 3	ROIs 1	ROIs 2	ROIs 3
AUC (counts.s)
60 mL	27.2 ± 2.9	31.4 ± 2.5	43.9 ± 1.7ac	72.8 ± 2.9	68.6 ± 2.5	56.1 ± 1.7ac
180 mL	35.3 ± 4.1	39.4 ± 3.2	49.0 ± 3.8a	64.7 ± 4.1	60.6 ± 3.2	51.0 ± 3.8a
P	< 0.09	< 0.031	< 0.1	< 0.09	< 0.031	< 0.1
Statistical moments (min)
60 mL	6.9 ± 0.3	7.7 ± 0.2c	8.5 ± 0.1ac	10.4 ± 0.3	10.5 ± 0.3	10.7 ± 0.2
180 mL	8.7 ± 0.2	9.0 ± 0.1	9.2 ± 0.1	9.8 ± 0.3	10.0 ± 0.3	10.1 ± 0.3
P	< 0.000011	< 0.000031	< 0.00061	< 0.2	< 0.1	< 0.07

¹60 mL vs 180 mL.

^aP < 0.05 vs ROIs 1,

^cP < 0.05 vs ROIs 2, ^eP < 0.05 vs ROIs 1. ROIs: Regions of interest.