Impact of endoscopy-based research on quality of life in healthy volunteers

Table 1 Changes in scores on the SF-36 questionnaires in HV according to different test drugs before and after endoscopic procedures

Test drug day	Physical score		P	Mental score		P	Total score		P
	0	14		0	14		0	14
Placebo	88.7 ± 5.9	88.2 ± 4.1	NS	85.7 ± 8.5	86.0 ± 7.8	NS	89.9 ± 6.2	89.8 ± 4.8	NS
Esomeprazole	85.7 ± 7.7	84.1 ± 6.0	NS	83.3 ± 6.2	83.0 ± 6.0	NS	86.2 ± 7.2	87.4 ± 4.8	NS
Clopidogrel	86.6 ± 6.5	85.5 ± 6.7	NS	84.0 ± 7.3	83.8 ± 8.2	NS	88.1 ± 6.1	87.0 ± 6.3	NS
Prednisolone	85.1 ± 5.2	82.2 ± 9.6	NS	81.9 ± 7.0	82.6 ± 6.4	NS	87.0 ± 5.4	85.7 ± 6.7	NS
Rofecoxib	86.2 ± 8.2	86.4 ± 3.1	NS	85.0 ± 6.2	84.5 ± 4.7	NS	88.3 ± 6.5	88.4 ± 3.1	NS
Total Scores	86.4 ± 1.3	85.4 ± 2.0	NS	83.5 ± 1.3	84.2 ± 1.2	NS	87.8 ± 1.2	87.8 ± 1.5	NS

Test drugs were given for one week alone and for an additional week in combination with low-dose aspirin. Four-week washout periods were performed between the different drug phases. Results expressed in mean ± SD, paired t-test: P > 0.05 listed as NS. HV: Healthy volunteers.