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©2010 Baishideng.
World J Gastroenterol. Jan 28, 2010; 16(4): 431-438
Published online Jan 28, 2010. doi: 10.3748/wjg.v16.i4.431
Published online Jan 28, 2010. doi: 10.3748/wjg.v16.i4.431
Table 1 Hospitalized prevalence of severe CD and ulcerative colitis across health boards, 1999-2007
Health board | Map1 | No. of LSOAs | Deprivation score (mean ± SD) | CD | UC | ||||
Cases | Prevalence (per 100 000) | 95% CI | Cases | Prevalence (per 100 000) | 95% CI | ||||
Blaenau Gwent | 1 | 47 | 33.8 ± 12.7 | 31 | 44.7 | (30.4-63.5) | 27 | 39.0 | (25.7-56.7) |
Bridgend | 2 | 85 | 23.2 ± 13.0 | 41 | 31.5 | (22.6-42.7) | 62 | 47.6 | (36.5-61.0) |
Caerphilly | 3 | 110 | 27.0 ± 14.1 | 97 | 57.0 | (46.2-69.5) | 91 | 53.5 | (43.0-65.6) |
Cardiff | 4 | 203 | 21.3 ± 18.0 | 158 | 50.9 | (43.3-59.5) | 137 | 44.1 | (37.1-52.2) |
Carmarthenshire | 5 | 112 | 22.0 ± 10.3 | 125 | 71.3 | (59.3-84.9) | 67 | 38.2 | (29.6-48.5) |
Ceredigion | 6 | 47 | 15.0 ± 6.2 | 35 | 46.0 | (32.0-63.9) | 30 | 39.4 | (26.6-56.2) |
Conwy | 7 | 71 | 18.0 ± 11.0 | 64 | 57.8 | (44.5-73.8) | 84 | 75.9 | (60.6-94.0) |
Denbighshire | 8 | 58 | 20.4 ± 15.6 | 56 | 59.0 | (44.6-76.7) | 56 | 59.0 | (44.6-76.7) |
Flintshire | 9 | 92 | 15.0 ± 10.2 | 74 | 49.6 | (38.9-62.2) | 77 | 51.6 | (40.7-64.5) |
Gwynedd | 10 | 75 | 17.3 ± 7.4 | 63 | 53.7 | (41.2-68.7) | 70 | 59.6 | (46.5-75.4) |
Isle of Anglesey | 11 | 44 | 20.7 ± 8.8 | 43 | 63.0 | (45.6-84.9) | 43 | 63.0 | (45.6-84.9) |
Merthyr Tydfil | 12 | 36 | 37.2 ± 17.0 | 26 | 46.7 | (30.5-68.4) | 50 | 89.7 | (66.6-118.3) |
Monmouthshire | 13 | 58 | 12.2 ± 6.0 | 37 | 42.9 | (30.2-59.1) | 44 | 51.0 | (37.1-68.5) |
Neath Port Talbot | 14 | 91 | 28.2 ± 14.4 | 76 | 56.0 | (44.1-70.0) | 53 | 39.0 | (29.2-51.0) |
Newport | 15 | 94 | 22.0 ± 15.6 | 73 | 52.4 | (41.1-65.9) | 71 | 51.0 | (39.8-64.3) |
Pembrokeshire | 16 | 71 | 19.4 ± 8.9 | 44 | 38.0 | (27.6-51.0) | 47 | 40.6 | (29.8-54.0) |
Powys | 17 | 80 | 14.3 ± 6.1 | 44 | 34.2 | (24.9-46.0) | 62 | 48.2 | (37.0-61.8) |
Rhondda Cynon Taff | 18 | 152 | 29.2 ± 15.4 | 116 | 50.0 | (41.3-60.0) | 125 | 53.9 | (44.9-64.2) |
Swansea | 19 | 147 | 22.6 ± 17.8 | 101 | 44.9 | (36.6-54.6) | 109 | 48.5 | (39.8-58.5) |
Torfaen | 20 | 60 | 21.3 ± 10.8 | 46 | 50.6 | (37.1-67.5) | 51 | 56.1 | (41.8-73.8) |
Vale of Glamorgan | 21 | 78 | 15.0 ± 10.5 | 49 | 40.7 | (30.1-53.7) | 74 | 61.4 | (48.2-77.1) |
Wrexham | 22 | 85 | 19.9 ± 13.5 | 68 | 52.5 | (40.8-66.5) | 52 | 40.2 | (30.0-52.6) |
All Wales | 1896 | 21.7 ± 14.3 | 1467 | 50.1 | (47.5-52.7) | 1482 | 50.6 | (48.0-53.2) |
Table 2 Age- and sex-specific hospitalized prevalence rates for severe CD and UC, 1999-2007
CD | UC | ||||||
Cases | Prevalence (per 100 000) | 95% CI | Cases | Prevalence (per 100 000) | 95% CI | ||
Males | All | 601 | 42.2 | (38.9-45.8) | 726 | 51.0 | (47.4-54.9) |
0-15 | 25 | 8.4 | (5.5-12.5) | 20 | 6.7 | (4.1-10.4) | |
16-29 | 151 | 61.4 | (52.0-72.0) | 115 | 46.7 | (38.6-56.1) | |
30-44 | 141 | 47.6 | (40.1-56.1) | 168 | 56.7 | (48.5-66.0) | |
45-64 | 163 | 44.5 | (38.0-51.9) | 199 | 54.4 | (47.1-62.5) | |
65+ | 119 | 54.5 | (45.2-65.3) | 224 | 103 | (89.7-117) | |
Females | All | 866 | 57.4 | (53.7-61.4) | 756 | 50.1 | (46.6-53.8) |
0-15 | 21 | 7.5 | (4.6-11.4) | 11 | 3.9 | (2.0-7.0) | |
16-29 | 185 | 76.0 | (65.5-87.8) | 114 | 46.9 | (38.6-56.3) | |
30-44 | 232 | 74.3 | (65.1-84.5) | 166 | 53.2 | (45.4-61.9) | |
45-64 | 222 | 58.9 | (51.4-67.2) | 189 | 50.1 | (43.3-57.8) | |
65+ | 205 | 69.4 | (60.2-79.6) | 276 | 93.4 | (82.7-105) | |
All Wales | 1467 | 50.1 | (47.5-52.7) | 1482 | 50.6 | (48.0-53.2) |
Table 3 Mortality at 1 year following hospitalization for severe CD and UC, 1999-2007
CD | UC | ||||||||
Cases | No. of deaths | Mortality rate (%) | Adjusted OR1 (95% CI) | Cases | No. of deaths | Mortality rate (%) | Adjusted OR1(95% CI) | ||
All | 1261 | 86 | 6.8 | 1300 | 119 | 9.2 | |||
Age groups by gender | |||||||||
Male | All | 506 | 30 | 5.9 | 633 | 50 | 7.9 | ||
0-15 | 22 | 0 | 0.0 | 16 | 0 | 0.0 | |||
16-29 | 128 | 0 | 0.0 | 101 | 0 | 0.0 | |||
30-44 | 119 | 1 | 0.8 | 145 | 0 | 0.0 | |||
45-64 | 136 | 5 | 3.7 | 172 | 7 | 4.1 | |||
65+ | 99 | 24 | 24.2 | 199 | 43 | 21.6 | |||
Female | All | 755 | 56 | 7.4 | 667 | 69 | 10.3 | ||
0-15 | 19 | 0 | 0.0 | 8 | 0 | 0.0 | |||
16-29 | 165 | 2 | 1.2 | 96 | 0 | 0.0 | |||
30-44 | 202 | 5 | 2.5 | 151 | 3 | 2.0 | |||
45-64 | 189 | 7 | 3.7 | 169 | 8 | 4.7 | |||
65+ | 179 | 42 | 23.5 | 243 | 58 | 23.9 | |||
Sex | |||||||||
Male | 504 | 30 | 6.0 | Ref. | 633 | 50 | 7.9 | Ref. | |
Female | 754 | 56 | 7.4 | 1.05 (0.63-1.74) | 667 | 69 | 10.3 | 1.03 (0.67-1.57) | |
Colectomy performed | |||||||||
Yes | 193 | 9 | 4.7 | Ref. | 162 | 17 | 10.5 | Ref. | |
No | 1068 | 77 | 7.2 | 1.59 (0.74-3.41) | 1138 | 102 | 9.0 | 0.57 (0.31-1.05) | |
Social deprivation | |||||||||
I (least deprived) | 229 | 16 | 7.0 | 0.99 (0.45-2.17) | 234 | 20 | 8.5 | 0.83 (0.42-1.65) | |
II | 236 | 10 | 4.2 | 0.49 (0.21-1.18) | 245 | 21 | 8.6 | 0.89 (0.45-1.76) | |
III | 257 | 23 | 8.9 | 1.23 (0.60-2.55) | 282 | 27 | 9.6 | 0.86 (0.46-1.61) | |
IV | 277 | 20 | 7.2 | 0.85 (0.41-1.77) | 280 | 27 | 9.6 | 0.99 (0.52-1.86) | |
V (most deprived) | 262 | 17 | 6.5 | Ref. | 259 | 24 | 9.3 | Ref. | |
Urban/rural residence | |||||||||
Under 2500 people | 256 | 17 | 6.6 | Ref. | 277 | 22 | 7.9 | Ref. | |
2500-9999 | 205 | 13 | 6.3 | 0.76 (0.33-1.76) | 222 | 21 | 9.5 | 1.29 (0.64-2.59) | |
10 000-24 999 | 278 | 26 | 9.4 | 1.48 (0.72-3.06) | 280 | 24 | 8.6 | 1.17 (0.60-2.30) | |
25 000-99 999 | 260 | 15 | 5.8 | 0.71 (0.32-1.60) | 274 | 28 | 10.2 | 1.48 (0.77-2.85) | |
At least 100 000 | 262 | 15 | 5.7 | 0.67 (0.29-1.54) | 247 | 24 | 9.7 | 1.58 (0.80-3.14) | |
Distance from hospital | |||||||||
< 3 km | 187 | 14 | 7.5 | Ref. | 211 | 21 | 10.0 | Ref. | |
3-4.99 km | 145 | 6 | 4.1 | 0.55 (0.19-1.59) | 159 | 14 | 8.8 | 0.97 (0.44-2.10) | |
5-9.99 km | 269 | 18 | 6.7 | 1.03 (0.46-2.31) | 285 | 25 | 8.8 | 0.91 (0.47-1.76) | |
10-19.99 km | 318 | 22 | 6.9 | 1.14 (0.52-2.49) | 303 | 30 | 9.9 | 0.94 (0.49-1.80) | |
≥ 20 km | 207 | 16 | 7.7 | 1.14 (0.49-2.65) | 206 | 19 | 9.2 | 1.03 (0.50-2.13) |
Table 4 Mortality at 5 years following hospitalization for severe Crohn’s disease and ulcerative colitis, 1999-2007
CD | UC | ||||||||
Cases2 | No. of deaths | Mortality rate (%) | Adjusted OR1 (95% CI) | Cases2 | No. of deaths | Mortality rate (%) | Adjusted OR1(95% CI) | ||
All | 535 | 78 | 14.6 | 567 | 118 | 20.8 | |||
Age groups by sex | |||||||||
Male | All | 209 | 28 | 13.4 | 275 | 55 | 20.0 | ||
0-15 | 10 | 0 | 0.0 | 5 | 0 | 0.0 | |||
16-29 | 50 | 0 | 0.0 | 43 | 1 | 2.3 | |||
30-44 | 52 | 2 | 3.8 | 73 | 0 | 0.0 | |||
45-64 | 58 | 8 | 13.8 | 63 | 4 | 6.3 | |||
65+ | 39 | 18 | 46.2 | 91 | 50 | 54.9 | |||
Female | All | 326 | 50 | 15.3 | 292 | 63 | 21.6 | ||
0-15 | 9 | 0 | 0.0 | 4 | 0 | 0.0 | |||
16-29 | 72 | 1 | 1.4 | 40 | 1 | 2.5 | |||
30-44 | 91 | 3 | 3.3 | 59 | 2 | 3.4 | |||
45-64 | 84 | 10 | 11.9 | 86 | 6 | 7.0 | |||
65+ | 70 | 36 | 51.4 | 103 | 54 | 52.4 | |||
Sex | |||||||||
Male | 209 | 28 | 13.4 | Ref. | 275 | 55 | 20.0 | Ref. | |
Female | 326 | 50 | 15.3 | 0.96 (0.52-1.76) | 292 | 63 | 21.6 | 0.76 (0.44-1.31) | |
Colectomy performed | |||||||||
Yes | 89 | 10 | 11.2 | Ref. | 72 | 15 | 20.8 | Ref. | |
No | 446 | 68 | 15.2 | 1.48 (0.63-3.52) | 495 | 103 | 20.8 | 0.59 (0.26-1.33) | |
Social deprivation | |||||||||
I (least deprived) | 110 | 14 | 12.7 | 0.53 (0.20-1.39) | 110 | 24 | 21.8 | 1.39 (0.61-3.19) | |
II | 102 | 9 | 8.8 | a0.23 (0.08-0.68) | 110 | 19 | 17.3 | 0.85 (0.35-2.05) | |
III | 112 | 16 | 14.3 | 0.56 (0.21-1.46) | 114 | 31 | 27.2 | 1.62 (0.73-3.58) | |
IV | 106 | 21 | 19.8 | 1.09 (0.45-2.68) | 112 | 23 | 20.5 | 1.29 (0.55-3.02) | |
V (most deprived) | 105 | 18 | 17.1 | Ref. | 121 | 21 | 17.4 | Ref. | |
Urban/rural residence | |||||||||
Under 2500 people | 103 | 11 | 10.7 | Ref. | 124 | 28 | 22.6 | Ref. | |
2500-9999 | 89 | 16 | 18.0 | 1.42 (0.49-4.12) | 105 | 22 | 21.0 | 0.64 (0.26-1.53) | |
10 000-24 999 | 124 | 21 | 16.9 | 1.32 (0.49-3.56) | 109 | 18 | 16.5 | 0.47 (0.19-1.17) | |
25 000-99 999 | 99 | 15 | 15.2 | 0.75 (0.26-2.14) | 121 | 26 | 21.5 | 0.86 (0.37-1.97) | |
≥ 100 000 | 120 | 15 | 12.5 | 0.89 (0.31-2.54) | 108 | 24 | 22.2 | 0.84 (0.35-1.98) | |
Distance from hospital | |||||||||
< 3 km | 87 | 14 | 16.1 | Ref. | 101 | 24 | 23.8 | Ref. | |
3-4.99 km | 73 | 9 | 12.3 | 0.52 (0.16-1.63) | 67 | 14 | 20.9 | 0.80 (0.31-2.09) | |
5-9.99 km | 111 | 12 | 10.8 | 0.71 (0.25-2.01) | 123 | 22 | 17.9 | 0.80 (0.35-1.85) | |
10-19.99 km | 135 | 17 | 12.6 | 0.81 (0.30-2.19) | 112 | 27 | 24.1 | 0.97 (0.41-2.29) | |
≥ 20 km | 70 | 15 | 21.4 | 1.26 (0.42-3.78) | 87 | 16 | 18.4 | 0.78 (0.31-2.00) |
- Citation: Button LA, Roberts SE, Goldacre MJ, Akbari A, Rodgers SE, Williams JG. Hospitalized prevalence and 5-year mortality for IBD: Record linkage study. World J Gastroenterol 2010; 16(4): 431-438
- URL: https://www.wjgnet.com/1007-9327/full/v16/i4/431.htm
- DOI: https://dx.doi.org/10.3748/wjg.v16.i4.431