Impact of human leukocyte antigen mismatching on outcomes of liver transplantation: A meta-analysis

Table 1 Contents of included studies

Author	Location	Immunosuppression	Number of patients	Contents
Meyer et al[9]	France	Cyclosporine, methylpred- nisolone and azathioprine	162	HLA-A, B and DR (5-yr graft survival); HLA-DR (1- and 5-yr graft survival)
Jakab et al[10]	American	NS	631	HLA-A, B and DR (1- and 5-yr graft survival); HLA-A and HLA-B (5-yr graft survival)
Neumanna et al[8]	Germany	Cyclosporine, azathioprine and prednisolone	836	HLA-A, B and DR (1- and 5-yr graft survival and rejection); HLA-A and HLA-DR (1- and 5-yr graft survival); HLA-B (1-yr graft survival)
Hashimoto et al[11]	Japan	Cyclosporine, methylpred- nisolone and azathioprine	50	HLA-A, B and DR (1- and 5-yr graft survival)
Langrehr et al[12]	Germany	Cyclosporine, azathioprine and prednisolone	165	HLA-A, B and DR (1- and 5-yr graft survival and rejection)
Suehiro et al[13]	Japan	Tacrolimus and Steroids	104	HLA-A, B and DR (1- and 5-yr graft survival and rejection)
Harihara et al[14]	Japan	Tacrolimus and Steroids	85	HLA-A, B and DR (rejection)
Balan et al[7]	American	Cyclosporine, prednisone, and azathioprine or tacrolimus	799	HLA-A, B and DR (1- and 5-yr graft survival); HLA-A (5-yr graft survival)
Sugawara et al[16]	Japan	Tacrolimus and methyl- prednisolone	113	HLA-DR (1-yr graft survival)
Doran et al[22]	Germany	NS	446	HLA-A, B and DR (1- yr graft survival); HLA-A and HLA-B (1-yr graft survival)
Poli et al[15]	Italy	Cyclosporine, azathioprine and tacrolimus	814	HLA-DR (5-yr graft survival)
Yagihashi et al[18]	American	Cyclosporine, azathioprine and tacrolimus	347	HLA-A, HLA-B and HLA-DR (1-yr graft survival)
Nikaein et al[21]	American	Cyclosporine and prednisone	701	HLA-A, B and DR (1-yr graft survival); HLA-A (1- and 5-yr graft survival); HLA-B and HLA-DR (1-yr graft survival)
Markus et al[20]	American	NS	527	HLA-A (5-yr graft survival); HLA-DR (1-yr graft survival)
Donaldson et al[19]	Britain	Cyclosporine, azathioprine	466	HLA-A, B and DR (1-yr graft survival and rejection); HLA-A and HLA-B (1-yr graft survival)
Knechtle et al[17]	American	NS	324	HLA-A, B and DR (1-yr graft survival); HLA-A, HLA-B and HLA-DR (1-yr graft survival)

NS: Not specified; HLA: Human leukocyte antigen.

Table 2 Methodological quality of the controlled trials

Study	Selection criteria specified	Study design	Score	Other causing of death report	Dropouts explained	Funding
Meyer C	Yes	RCS	30	No	No	NS
Jakab SS	Yes	RCS	32	Yes	Yes	NS
Neumanna UP	Yes	PCS	31	No	No	NS
Morioka D	Yes	RCS	30	No	No	NS
Langrehr JM	Yes	RCS	33	Yes	Yes	NS
Suehiro T	Yes	RCS	30	Yes	No	NS
Harihara Y	Yes	RCS	30	No	No	NS
Vijayan B	Yes	PCS	35	Yes	Yes	NS
Sugawara Y	Yes	RCS	30	Yes	No	NS
Doran	Yes	RCS	30	No	No	NS
Poli F	Yes	RCS	31	No	No	NS
Yagihashi A	Yes	RCS	30	No	No	NS
Afzal N	Yes	RCS	33	No	No	NS
Markus BH	Yes	RCS	32	No	Yes	NS
Donaldson P	Yes	RCS	32	No	Yes	NS
Knechtle SJ	Yes	RCS	31	No	Yes	NS

RCS: Retrospective cohort studies; NS: Not specified.