Prevalence of type 2 diabetes in Algerian patients with hepatitis C virus infection

Table 1 Characteristics of all patients in the chronic viral hepatitis cohort n (%)

Clinical features	Virological diagnosis		P
	HBV (n = 126)	HCV (n = 290)
Age (yr)
< 40	57 (45.2)	13 (4.5)	< 0.001
40-59	60 (47.6)	193 (66.6)	< 0.001
≥ 60	9 (7.1)	84 (29)	< 0.001
Male sex	79 (62.7)	78 (26.9)	< 0.001
Family history of diabetes	38 (30.2)	103 (35.5)	0.28
BMI (kg/m2), mean ± SD	25.22 ± 4.48	26.27 ± 4.51	0.05
BMI ≥ 25 kg/m2	68 (54)	161 (55.5)	0.42
Metabolic syndrome	20 (15.9)	122 (42.1)	< 0.0001
Increased ALT	15 (11.9)	177 (61)	< 0.0001
Cirrhosis	5 (4)	51 (17.6)	0.00018

HBV: Hepatitis B virus; HCV: Hepatitis C virus; BMI: Body mass index; ALT: Alanine aminotransferase.

Table 2 Analysis of variables associated with diabetes in chronic viral hepatitis n (%)

Variables	Virological diagnosis		P
	HBV (n = 121)	HCV (n = 261)
Diabetic	6 (5)	102 (39.1)	< 0.0001
Age (yr)
< 40	0/56 (0)	1/12 (8.3)
40-59	4/58 (6.9)	61/174 (35.1)	< 0.0001
≥ 60	2/7 (28.6)	40/75 (52.6)	0.56
Family history of diabetes	1/37 (2.7)	52/92 (56.5)	< 0.0001
BMI ≥ 25 kg/m2	5/66 (7.6)	70/147 (47.6)	< 0.0001
Metabolic syndrome	4/18 (22.2)	75/108 (69.4)	< 0.001
Increased ALT	2/14 (14.3)	79/155 (51)	0.01
Cirrhosis	1/5 (20)	29/43 (67.4)	0.058
No cirrhosis	5/116 (4.3)	73/218 (33.5)	< 0.0001

HBV: Hepatitis B virus; HCV: Hepatitis C virus; BMI: Body mass index; ALT: Alanine aminotransferase.

Table 3 Factors associated with the development of diabetes in patients chronically infected with hepatitis virus

Variables	Odds ratio	95% CI	P value
Metabolic syndrome	12.35	6.18-24.67	0.00001
Hepatitis C	4.73	1.69-13.20	0.0029
Family history of diabetes	3.2	1.67-6.13	0.0004
Increased ALT	2.22	1.09-4.52	0.027

ALT: Alanine aminotransferase.