Postoperative adjuvant antiviral therapy for hepatitis B/C virus-related hepatocellular carcinoma: A meta-analysis

Table 1 Characteristics of the included studies

RCT/NRCT	Medium follow-up time (treatment, control) (mo)	HBV/HCV	Curative intervention	Regimen	Treatment	Control	Cumulative survival rate at year	Cumulative recurrence rate at year	SVR/non-SVR	Ref.
NRCT	32, 31	HCV	Hepatectomy, RFA, PEI, PMCT, ablation under LC	IFNα 6 MIU Qd × 2 w + tiw × 22 w	42	42	3, 5, 7	1, 3, 5, 7	29/13	[22]
NRCT	37, 45	HCV	Hepatectomy, RFA, PEI, PMCT, ablation under LC	IFNα 3 MIU tiw × 48 w	16	16	1, 2, 3, 4	1, 2, 3	2/14	[23]
NRCT	NA	HCV	Hepatectomy, RFA, PEI, PMCT	IFNα 3-6 MIU tiw × 24-48 w	53	399	3, 6, 9	NA	17/36	[24]
NRCT	< 36	HCV	PEI, RFA, PMCT	IFNα-2b 3-5 MIU biw + ribavirin 1000-1200 mg Qd × 24-48 w	16	33	1, 2, 3	1, 2, 3	10/6	[25]
NRCT	28, 23	HCV	RFA	IFNα-2b 3 MIU biw × as long as possible	24	33	NA	1, 2, 3	1/23	[26]
RCT	85 ± 16	HCV	PEI	IFN 6 MIU tiw × 48 w	49	25	1, 3, 5, 7	1, 3, 5	14/35	[8]
RCT	25.0 (2.0-34.6)	HCV	Hepatectomy, PEI	IFNβ 6 MIU biw × 36 m	10	10	NA	1, 2	0/10	[27]
NRCT	38.0 (9.2-78.2),	HBV	Hepatectomy, RFA	lamivudine 100 mg Qd × as long as possible	16	33	1, 2, 3	1, 2, 3	NA	[28]
	32.6 (0.5-75.7)
NRCT	53	HBV	Hepatectomy, ablation	IFNα biw/tiw ×≥ 24 w	11	69	NA	3, 5, 10	NA	[30]
NRCT	31	HBV	Hepatectomy, ablation	lamivudine 100 mg Qd	30	40	1, 2	1, 2	NA	[29]
RCT	30	HBV 77	Hepatectomy	IFNα-2b 10 MIU/m2 tiw × 16 w	40	40	1, 3, 5	NA	NA	[16]
		HCV 2
		HBV + HCV 1
RCT	45	HCV 80	Hepatectomy	IFNα 3 MIU tiw × 48 w	76	74	3, 5	NA	2/74	[31]
		HBV + HCV 70
RCT	27 (4-53)	HBV 16	PAI	IFNα 3 MIU tiw × 24 w/ IFNα 3 MIU Qd × 10 d/m × 6 m + 10 d/3 m × 18 m	18	9	NA	1, 2, 3, 4	NA	[32]
		HCV 13
		HBV + HCV 11

¹3 were excluded from the final analysis as they had already experienced one recurrence. NA: Not available; NRCT: Non-randomized controlled trial; RCT: Randomized controlled trial; HBV: Hepatitis B virus; HCV: Hepatitis C virus; IFN: Interferon; SVR: Sustained virologic response; RFA: Radiofrequency ablation; PEI: Percutaneous ethanol injection; PMCT: Percutaneous microwave coagulation therapy; PAI: Percutaneous acetic acid injection.