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©2010 Baishideng.
World J Gastroenterol. May 28, 2010; 16(20): 2504-2519
Published online May 28, 2010. doi: 10.3748/wjg.v16.i20.2504
Published online May 28, 2010. doi: 10.3748/wjg.v16.i20.2504
Table 1 Clinicopathological and therapeutic data of nine new cases of extranodal FDC sarcoma (Cases 1-9)
Case No. | Age (yr) | Gender | Sites | Size (cm) | HG | MC (/10 HPF) | Year of onset | Initial diagnoses | Initial treatment | Recurrence, DFT (mo) | Disease status | Follow-up (mo) |
1 | 60 | M | Tonsil | 5.0 | Low | < 1 | 2002 | Granuloma | Surg + RT | NED | 86 | |
2 | 35 | F | Parapharyn-geal space | 5.0 | High | 10 | 2003 | NPC | Surg | LR, 2 | DOD | 12 |
3 | 63 | M | Infratem-poral fossa | 4.0 | Low | 1 | 2003 | PNET | Surg + RT + ChT | NED | 72 | |
4 | 30 | F | Pyform sinus | 5.0 | High | 9 | 2004 | FDC sarcoma | Surg + RT | DM (lung), 25 | DOD | 25 |
5 | 23 | M | Mediastinum | 8.0 | Low | 3 | 2006 | MPNST | Surg + RT + ChT | DM (bone), 45 | AWD | 45 |
6 | 45 | M | Liver | 14.5 | Low | < 1 | 2007 | FDC sarcoma | Surg | NED | 27 | |
7 | 36 | F | Mesentery | 15.0 | High | 7 | 2007 | Malignant GIST | Surg | DM (liver, ovary), 4 | AWD | 27 |
8 | 28 | F | Parapharyn-geal space | 6.0 | High | 3 | 2008 | FDC sarcoma | Surg + RT + ChT | DM (lung), 14 | AWD | 22 |
9 | 55 | M | Tonsil | 2.0 | High | 9 | 2008 | FDC sarcoma | Surg + RT | LR, 18 | AWD | 21 |
Table 2 Primary antibodies and antigen retrieving procedures
Antibodies | Origins and clones | Dilutions | Antigen retrieval | Sources |
Pan-cytokeratin | MAb, AE1/AE3 | 1:80 | MW-citrate | Invitrogen |
EMA | MAb, Mc5 | 1:100 | MW-citrate | Invitrogen |
Vimentin | MAb, V9 | 1:200 | MW-citrate | NeoMarker |
Desmin | MAb, ZC18 | 1:80 | MW-citrate | Invitrogen |
SMA | MAb, IA4 | 1:100 | Not treated | Invitrogen |
CD45 | MAb, RP2/18 | 1:120 | MW-citrate | Novacastro |
CD68 | MAb, KP1 | 1:200 | MW-citrate | Zeta |
S-100 protein | PAb, rabbit | 1:400 | MW-citrate | Dako |
CD21 | MAb, 2G9 | 1:20 | AC-EDTA | NeoMarker |
CD23 | MAb, SP23 | 1:25 | MW-citrate | NeoMarker |
CD35 | MAb, KuN241 | 1:20 | AC-EDTA | NeoMarker |
CD1a | MAb, MTB1 | 1:20 | MW-citrate | Zeta |
Podoplanin | MAb, D2-40 | 1:50 | AC-EDTA | Zeta |
p53 protein | MAb, DO-7 | 1:100 | AC-EDTA | NeoMarker |
Ki-67 antigen | MAb, MIB-1 | 1:200 | AC-EDTA | Zymed |
Table 3 Histological features of low- and high-grade FDC sarcomas
Parameters | Low-grade phenotypes | High-grade phenotypes |
Architectures | Nodular patterns in whorl, storiform and fascicular arrangement | Diffuse and sheet-like patterns |
Cellular features | Spindle or blunt cells with mild nuclear atypia and a small nucleolus in > 90% of area | Epithelioid or pleomorphic cells with marked nuclear atypia and large nucleoli |
Mitotic counts | < 5/10 HPF | ≥ 5/10 HPF |
Ki-67-LI | < 10% | ≥ 10% |
Necrosis | Absent | Frequently present |
Lymphocyte infiltration | Sporadic and throughout the lesion | Focal or regional |
Table 4 Expression of lineage-specific and kinetic-associated molecules and EBV-encoded RNA (EBER) in nine FDC sarcomas (Cases 1-9)
Cases | CK | EMA | Vimentin | CD45 | CD21 | CD23 | CD35 | Podoplanin | CD68 | S-100 protein | p53 protein1 | Ki-67-LI (%) | EBER |
1 | - | 1+ | 3+ | - | 3+ | NT | 1+ | NT | NT | NT | 3+ | 4 | NT |
2 | - | - | NT | - | 2+ | NT | 2+ | NT | NT | - | 2+ | 15 | NT |
3 | - | 1+ | 2+ | - | 2+ | 3+ | - | 3+ | NT | - | 2+ | 1 | - |
4 | - | - | 3+ | - | 3+ | 2+ | 2+ | - | - | 1+ | 2+ | 8 | - |
5 | - | - | 3+ | - | 2+ | 2+ | 3+ | 2+ | 1+ | 2+ | 2+ | 15 | - |
6 | - | - | NT | - | 1+ | 2+ | - | - | 1+ | 1+ | - | 10 | + |
7 | - | - | 2+ | - | 1+ | 3+ | 3+ | - | - | - | 2+ | 40 | - |
8 | - | - | 1+ | - | 3+ | 2+ | - | 2+ | 2+ | 1+ | 2+ | 20 | - |
9 | - | - | 2+ | - | 1+ | 2+ | 1+ | - | - | - | 2+ | 35 | - |
Table 5 Clinicopathologic and therapeutic data of 97 cases of extranodal FDC sarcoma obtained from literatures (Cases 10-106)
Cases No. | Origins | Age (yr) | Gender | Size (cm) | Sites | Initial treatment (responses) | Recurrence, DFT (mo) | Status | Follow-up (mo) |
10 | Chan et al[24], 1994 | 44 | M | 1.5 | Tonsil | Surg | NED | 36 | |
11 | Chan et al[24], 1994 | 63 | F | 3 | Palate | Surg + RT | NED | 54 | |
12 | Hollowood et al[25], 1995 | 23 | F | 6.5 | Small intestine | Surg | LR (2 times), 6 | AWD | 24 |
13 | Hollowood et al[25], 1995 | 63 | M | NA | Pancreas head | Surg | LR, 8 | DOD | 11 |
14 | Nayler et al[26], 1996 | 18 | F | 2 | Tonsil | Surg + ChT | NA | NA | |
15 | Perez-Ordonez et al[16], 1996 | 40 | F | NA | Abdomen | Surg + ChT | LR and DM (liver), 12 | AWD | 24 |
16 | Perez-Ordonez et al[16], 1996 | 62 | F | NA | Tonsil | Surg | NED | 12 | |
17 | Perez-Ordonez et al[16], 1996 | 62 | M | NA | Mediastinum | Surg + ChT | DM (lung), 24 | AWD | 24 |
18 | Perez-Ordonez et al[16], 1996 | 46 | M | NA | Mediastinum | Surg + RT | NED | 12 | |
19 | Perez-Ordonez et al[16], 1996 | 31 | M | NA | Mediastinum | Surg | NED | 10 | |
20 | Perez-Ordonez et al[16], 1996 | 75 | F | NA | Spleen | Surg | LR, 11 | DOD | 11 |
21 | Selves et al[27], 1996 | 68 | F | NA | Liver | Surg + ChT | NED | 30 | |
22 | Shek et al[28], 1996 | 35 | F | NA | Liver | Surg | LR (2 times), 30 | AWD | 60 |
23 | Chan et al[3], 1997 | 42 | M | 8 | Mesocolon, involving LN and peritoneum | Surg + ChT | LR, 18 | DOD | 18 |
24 | Chan et al[3], 1997 | 32 | M | NA | Tonsil | Surg + RT | LR and DM (LN), 54 | AWD | 54 |
25 | Chan et al[3], 1997 | 40 | F | 7 | Parapharyngeal space | Surg | LR, 12 | AWD | 12 |
26 | Chan et al[3], 1997 | 17 | M | 11 | Neck soft tissue | Surg + ChT | NA | NA | |
27 | Chan et al[3], 1997 | 25 | F | 7 | Neck soft tissue | Surg + RT | DM (lung), 20 | AWD | 20 |
28 | Beham-Schmid et al[29], 1998 | 44 | M | 2 | Nasopharynx | Surg + RT + ChT | NED | 20 | |
29 | Shek et al[30], 1998 | 37 | M | 1.5 | Liver | Surg | NED | 24 | |
30 | Shek et al[30], 1998 | 61 | F | 4 | Ampulla of Vater | Surg | NED | 9 | |
31 | Araújo et al[31], 1999 | 14 | M | 1.5 | Hard palate | Surg | NED | 5 | |
32 | Desai et al[32], 1999 | 45 | F | NA | Parapharyngeal space | Surg | LR, 31 | NED | 57 |
33 | Fisher et al[33], 1999 | 41 | F | 2.5 | Breast | Surg | LR and DM (LN), 36 | NED | 36 |
34 | Galati et al[34], 1999 | 65 | F | 1.5 | Thyroid | Surg + RT | NED | 36 | |
35 | Schwarz et al[35], 1999 | 62 | M | 15 | Abdominal wall | Surg + RT | NED | 8 | |
36 | Choi et al[36], 2000 | 28 | F | 4 | Neck soft tissue | Surg | DM (lung), 324 | AWD | 324 |
37 | Choi et al[36], 2000 | 66 | F | NA | Neck soft tissue | Surg + RT | DM (lung), 24 | AWD | 24 |
38 | Han et al[37], 2000 | 45 | M | 5 | Stomach | Surg | NED | 10 | |
39 | Chan et al[38], 2001 | 34 | M | NA | Nasopharynx | Surg | NED | 36 | |
40 | Chang et al[39], 2001 | 37 | F | 5 | Ascending colon | Surg | NED | 7 | |
41 | Chen et al[5], 2001 | 57 | F | 9.5 | Liver | Surveillance | AWD | 36 | |
42 | Chen et al[5], 2001 | 51 | F | 15 | Liver | Surg | NED | 12 | |
43 | Chiaramonte et al[40], 2001 | 39 | M | NA | Retroperitoneum | Surg | DM (LN and lung), 6 | DOD | 6 |
44 | Shah et al[41], 2001 | 33 | M | 9.5 | Lung | Surg + ChT | NA | NA | |
45 | Biddle et al[11], 2002 | 33 | M | NA | Pharynx | Surg + RT | DM (lung), 10 | AWD | 10 |
46 | Biddle et al[11], 2002 | 48 | F | 1.5 | Tonsil | Surg | NED | 6 | |
47 | Biddle et al[11], 2002 | 48 | M | 3.5 | Tonsil | Surg | NED | 8 | |
48 | Pileri et al[2], 2002 | 42 | M | NA | Mediastinum | Surg | NED | NA | |
49 | Vargas et al[42], 2002 | 54 | F | 3 | Tonsil | Surg | NED | 8 | |
50 | Vargas et al[42], 2002 | 54 | F | 6 | Left parotid | Surg + RT | LR, 6 | AWD | 8 |
51 | Ceresoli et al[43], 2003 | 35 | M | NA | Mediastinum | ChT + RT (Prog) | DOD | 7 | |
52 | Satoh et al[44], 2003 | 16 | M | 3 | Tonsil | Surg + RT + ChT | NED | 24 | |
53 | Geerts et al[45], 2004 | 40 | F | NA | Stomach, with DM (liver) | Surg | AWD | 5 | |
54 | Grogg et al[46], 2004 | 62 | M | NA | Left-thigh soft tissue | Surg | NED | 18 | |
55 | Grogg et al[46], 2004 | 57 | F | NA | Tonsil, involving LN | Surveillance | AWD | 8 | |
56 | Grogg et al[46], 2004 | 64 | F | 14 | Spleen, with DM (liver) | Surg + ChT | NED | 5 | |
57 | Kröber et al[47], 2004 | 76 | M | NA | Mediastinum | Surg + RT | NED | 24 | |
58 | O’Malley[48], 2004 | 38 | M | 5 | Cecum | Surg | NA | NA | |
59 | Shi et al[49], 2004 | 37 | M | 1.5 | Tonsil | Surg + ChT | NED | 36 | |
60 | Bradshaw et al[50], 2005 | 9 | M | 5 | Neck soft tissue | Surg | DM (lung), 60 | NED | 96 |
61 | Kazakov et al[13], 2005 | 38 | M | 1.8 | Skin | Surg | NA | NA | |
62 | Khalid et al[51], 2005 | 19 | F | 16 | Liver | ChT (PR) | DOD | 24 | |
63 | Torres et al[52], 2005 | 82 | M | 15 | Liver | Surg | NED | 18 | |
64 | Aydin et al[53], 2006 | 76 | F | 3.5 | Tonsil | Surg + RT | NED | 48 | |
65 | Choi et al[54], 2006 | 68 | M | NA | Dura mater | Surg + RT | NED | 7 | |
66 | Clement et al[55], 2006 | 27 | F | 4 | Tonsil | Surg + RT | NED | 6 | |
67 | Díaz de Liaño et al[56], 2006 | NA | NA | NA | Abdominal cavity | Surg | DM (liver), 18 | NED | 18 |
68 | Gan et al[57], 2006 | 32 | F | 4.5 | Parotid | Surg | NED | 20 | |
69 | Jiang et al[58], 2006 | 46 | F | 8.4 | Anterior mediastinum | ChT (stable) | DM (bone), 12 | NED | 19 |
70 | Jiang et al[59], 2006 | 46 | F | 21 | Pelvic/abdominal cavity, multiple | Surg | NED | 6 | |
71 | Kovács et al[60], 2006 | 65 | M | 4 | Lung | Surg | NED | 18 | |
72 | Li et al[61], 2006 | 19 | M | NA | Nasal cavity | Surg | NED | 11 | |
73 | Lu et al[62], 2006 | 72 | F | 7 | Groin | Surg | NA | NA | |
74 | Shen et al[63], 2006 | 64 | M | 10.5 | Pancreas | Surg | DM (liver), 18 | NED | 24 |
75 | Shia et al[64], 2006 | 30 | M | NA | Rectum | Surg | LR, 10 | AWD | 15 |
76 | Shia et al[64], 2006 | 29 | F | 12 | Lesser omentum | Surg | NED | 17 | |
77 | Shia et al[64], 2006 | 69 | F | NA | Tonsil | Surg + RT | DM (hilar LN+lung), 96 | AWD | 108 |
78 | Xu et al[65], 2006 | 16 | M | 5 | Adrenal | Surg | NA | NA | |
79 | Chang et al[66], 2007 | 64 | M | 16 | Chest wall | Surg | NED | 15 | |
80 | Leipsic et al[67], 2007 | 43 | M | 13 | Mediastinum | Surg | NA | NA | |
81 | Padilla-Rodríguez et al[68], 2007 | 35 | M | 21 | Retroperitoneal space | Surg + RT | NED | 24 | |
82 | Sander et al[69], 2007 | 44 | F | 11 | Spleen | Surg | DM (thorax, liver and kidney), 4 | DOD | 9 |
83 | Soriano et al[70], 2007 | 25 | F | 6 | Pelvis | Surg | LR, 2, 2nd Surg+RT | NED | 14 |
84 | Soriano et al[70], 2007 | 56 | M | 2 | Pancreas, involving LN | Surg + RT | LR, 2 | AWD | 7 |
85 | Soriano et al[70], 2007 | 33 | M | NA | Nasopharynx | Surg + RT | LR, 10 | DOD | 14 |
86 | Soriano et al[70], 2007 | 64 | F | 4 | Spleen, with liver involved | Surg + ChT | AWD | 29 | |
87 | Soriano et al[70], 2007 | 66 | M | 16 | Pleura | ChT (Prog) | DOD | 7 | |
88 | Tu et al[12], 2007 | 63 | M | 15 | Jejunum mesentery | Surg | NA | NA | |
89 | Tu et al[12], 2007 | 43 | M | 4 | Appendix | Surg | NA | NA | |
90 | Tu et al[12], 2007 | 28 | F | 15 | Stomach | Surg | DM (liver), 3 | AWD | 3 |
91 | Yuan et al[71], 2007 | 29 | M | 10 | Liver | Surg | LR, 6 | AWD | 6 |
92 | De Pas et al[72], 2008 | 40 | F | 4 | Breast | Surg | NED | 62 | |
93 | De Pas et al[72], 2008 | 53 | F | NA | Liver | Surg | DM (LN), 11 | DOD | 22 |
94 | De Pas et al[72], 2008 | 64 | F | 2.1 | Breast | Surg | NED | 20 | |
95 | Granados et al[73], 2008 | 57 | F | 13 | Liver | Surg | NED | 24 | |
96 | Liu et al[74], 2008 | 42 | M | 12 | Gastrocolic omentum | Surg | NA | NA | |
97 | Peng et al[75], 2008 | 60 | M | 7 | Mesentery | Surg | NA | NA | |
98 | Zhang et al[76], 2008 | 36 | M | NA | Nasopharynx | Surg | NED | 5 | |
99 | Zhang et al[76], 2008 | 32 | F | NA | Spleen | Surg | NA | NA | |
100 | An et al[77], 2009 | 40 | M | 5 | Liver | Surg | NED | 3 | |
101 | Denning et al[78], 2009 | 64 | F | 1.7 | Lung | Surg | NED | 24 | |
102 | Liu et al[79], 2009 | 75 | M | 4 | Liver | Surg | NA | NA | |
103 | Romero-Guadarrama et al[80], 2009 | 54 | F | 15 | Thigh soft tissue | Surg | LR, 12 | NED | 48 |
104 | Shen et al[81], 2009 | 43 | M | 5 | Appendix | Surg | LR, 8 | NED | 8 |
105 | Vaideeswar et al[82], 2009 | 50 | M | 2.5 | Tonsil | Surg | NED | 48 | |
106 | Xu et al[83], 2009 | 57 | F | 11 | Liver | Surg | NA | NA |
Table 6 Associations between clinicopathological parameters and recurrence risk in patients with extranodal FDC sarcoma
Pathologic parameters | Recurrence frequencies (%) | P values |
Age (yr) | ||
< 50 | 26/51 (51) | 0.072 |
≥ 50 | 11/35 (31) | |
Gender | ||
Male | 15/40 (38) | 0.290 |
Female | 22/46 (48) | |
Size (cm) | ||
< 5 | 4/25 (16) | 0.003 |
≥ 5 | 19/34 (56) | |
Histological grades | ||
Low | 12/37 (32) | 0.046 |
High | 15/26 (58) | |
Mitotic counts | ||
< 5/10 HPF | 8/30 (27) | 0.013 |
≥ 5/10 HPF | 18/31 (58) | |
Ki-67-LI | ||
< 10% | 2/6 (25) | 0.628 |
≥ 10% | 8/14 (57) | |
Necrosis | ||
Absent | 17/35 (49) | 0.307 |
Present | 13/29 (45) | |
Treatments | ||
Surgery alone | 22/52 (42) | 0.590 |
Surgery + adjuvant therapy | 15/31 (48) | |
Sites | ||
Abdominal/pelvic | 18/37 (49) | 0.372 |
Other sites | 20/53 (38) |
- Citation: Li L, Shi YH, Guo ZJ, Qiu T, Guo L, Yang HY, Zhang X, Zhao XM, Su Q. Clinicopathological features and prognosis assessment of extranodal follicular dendritic cell sarcoma. World J Gastroenterol 2010; 16(20): 2504-2519
- URL: https://www.wjgnet.com/1007-9327/full/v16/i20/2504.htm
- DOI: https://dx.doi.org/10.3748/wjg.v16.i20.2504