Increased levels of homocysteine in patients with ulcerative colitis

Table 1 Demographic features of UC and control groups

	Patients with UC (n = 55)	Healthy controls (n = 45)	P
Mean age (yr ± SD)	47.4 ± 13.80	46.4 ± 13.89	0.484
Gender (male/female)	38/17	31/14	0.983
Smoking status (%)	17 (30.9)	15 (33.3)	0.796
Localization (%)
Rectum/sigmoid	34 (61.8)
Left colitis	12 (21.8)
Pancolitis	9 (26.4)
Activity of UC (%)
Active	28 (50.9)
Inactive	27 (49.1)
Medical treatment (%)
5-ASA	41 (74.5)
Steroids	3 (5.5)
AZA	11 (20.0)

UC: Ulcerative colitis; ASA: Aminosalicylic-acid; AZA: Azathioprine.

Table 2 Hcys, folic acid and vitamin B12 levels in UC and control groups (95% CI)

	Patients (n = 55)	Controls (n = 45)	P
Hcy (μmol/L)	13.3 ± 1.93	11.3 ± 3.58	< 0.001
Folic acid (ng/mL)	5.1 ± 2.19	6.3 ± 0.87	< 0.001
Vitamin B12 (pg/mL)	250.4 ± 82.49	327.4 ± 73.90	< 0.001
Thromboemboli	3 (5.5%)	0 (0%)	0.250

Table 3 Correlation between Hcys and other variables among patients with UC

	Relationship coefficient	P
Disease duration	0.105	0.447
Folic acid	-0.311	0.021
Vitamin B12	-0.146	0.288
CRP	0.244	0.073
Clinical activity index	0.115	0.403