A rabbit model of pediatric nonalcoholic steatohepatitis: The role of adiponectin

doi:10.3748/wjg.15.912

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Feb 28, 2009 (publication date) through Nov 20, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Feb 28, 2009; 15(8): 912-918
Published online Feb 28, 2009. doi: 10.3748/wjg.15.912

Table 1 Comparison of indexes among three groups

	Control (n = 10)	Group A (n = 11)	Group B (n = 11)
BW (g)	809.0 ± 58.0 (625-1067)	973.0 ± 86.39 (545-1350)	816.1 ± 67.5 (545-1200)
WG (g)	928.0 ± 58.1 (570-1268)	1097.2 ± 72.3^a (779.0-1485)	1360.5 ± 107.6^c (537-1795)
LW (g)	54.4 ± 1.71 (47-67.5)	93.81 ± 6.64^b (62.2-121.9)	104.6 ± 4.42^b (74.4-123.5)
Liver index	0.032 ± 0.001 (0.02-0.04)	0.045 ± 0.002^a (0.03-0.06)	0.051 ± 0.005^a (0.04-0.1)
Adiponectin (&mgr;g/L)	27.36 ± 7.29 (18.14-39.55)	21.87 ± 4.84^a (12.12-28.47)	21.48 ± 4.60^a (16.71-32.16)
ALT/AST	1.00 ± 0.62	0.73 ± 0.38	0.70 ± 0.1
Lg (ALT)	1.60 ± 0.17	1.9 ± 0.29^b	1.84 ± 0.28^b
Lg (AST)	1.67 ± 0.18	2.08 ± 0.31^b	2.15 ± 0.30^b
Lg (TC)	0.24 ± 0.16	1.56 ± 0.46^b	1.56 ± 0.96^b
Lg (TG)	0.00 ± 0.16	1.03 ± 0.24^b	1.16 ± 0.33^b
Lg (IL-10)	2.26 ± 0.24	1.72 ± 0.38^b	1.83 ± 0.39^b
Lg (IL-6)	1.41 ± 0.33	1.38 ± 0.42	1.86 ± 0.21^b^d
Lg (INF-α)	0.66 ± 0.08	0.86 ± 0.43	1.18 ± 0.07^b^c

Group A: 8 wk model; Group B: 12 wk model. Compared with control,

^aP < 0.05,

^bP < 0.01. Compared with group A,

^cP < 0.05,

^dP < 0.01. BW: Body weight; WG: Weight gain; LW: Liver weight.

Table 2 Hepatic malondialdehyde (MDA) levels and hepatic superoxide dismutase (SOD) activities among three groups

Group	MDA (nmol/mg protein)	SOD (U/mg protein)
Control	2.73 ± 0.45	36.39 ± 5.2
Group A	4.84 ± 0.72^b	39.08 ± 3.5^b
Group B	5.51 ± 0.91^b	41.28 ± 3.2^b

^bP < 0.01 compared with control. There is no difference between group A and group B.

Table 3 Comparison of histopathology among three groups

	Group	0	1	2	3	4	χ²
Steatosis	Control		10	0	0	0
	Model A		0	1	3	7	17.6^b
	Model B		0	1	1	9	18.4^b 7.51^d
Inflammatory score	Control		10	0	0	0
	Model A		3	3	1	4	17.3^b
	Model B		2	4	0	5	17.2^b 4.9^c
Cytologic ballooning	Control	9	1	0	0	0
	Model A	0	5	6	0	0	10.8^b
	Model B	0	3	8	0	0	11.1^b
Perisinusoidal fibrosis	Control	10	0	0	0	0
	Model A	0	8	3	0	0	17.9^b
	Model B	0	7	4	0	0	17.6^b
Overall fibrosis	Control		10	0	0	0
	Model A		5	6	0	0	17.5^b
	Model B		4	7	0	0	17.6^b

Compared with control, ^aP < 0.05,

^bP < 0.01. Compared with model A,

^cP < 0.05,

^dP < 0.01.

Table 4 Pearson correlation of adiponectin with other variants

	Liver steatosis	Lg (TC)	Lg (Tg)	Lg (TNF-α)	Liver index
Adiponectin	-0.303	-0.424	-0.33	-0.412	-0.313
P value	0.046	0.008	0.03	0.01	0.04

Table 5 Degree of liver cell steatosis and Lg (TC) by stepwise multiple regression analysis

	B	t	P	R²
Constant	27.890	14.322	0.000
Lg (TC)	-1.333	2.978	0.006
Liver steatosis	-0.97	2.167	0.038	0.294

Citation: Fu JF, Fang YL, Liang L, Wang CL, Hong F, Dong GP. A rabbit model of pediatric nonalcoholic steatohepatitis: The role of adiponectin. World J Gastroenterol 2009; 15(8): 912-918
URL: https://www.wjgnet.com/1007-9327/full/v15/i8/912.htm
DOI: https://dx.doi.org/10.3748/wjg.15.912