Multidrug resistance protein 3 R652G may reduce susceptibility to idiopathic infant cholestasis

Table 1 Clinical characteristics of the 78 idiopathic infant cholestasis patients (mean ± SD)

	Patients	Controls
Age (mo)	1.8 ± 0.31	1.2 ± 0.25
TB (μmol/L)	194.43 ± 13.33a	12.94 ± 5.15
ALT (U/L)	123.80 ± 11.63a	29.09 ± 2.62
AST (U/L)	273.86 ± 27.90a	34.43 ± 2.43
γ-GT (U/L)	308.60 ± 46.30a	30.22 ± 9.90

^aP < 0.05 vs control. TB: Total bilirubin; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; γ-GT: γ-glutamyltransferase.

Table 2 MDR3 R652G genotypes and allele frequencies in patients and controls n (%)

Groups	n	Genotypes			Allelefrequency (%)	P-value
		A/A	A/G	G/G
Patients	78	74 (94.9)	4 (5.1)	0	2.6	< 0.051
Controls	113	95 (84.1)	18 (15.9)	0	8.0

¹Fisher’s exact test between patients and controls for genotype frequency. P = 0.022; OR, 0.29; 95% CI, 0.12-0.84.

Table 3 Comparison of clinical characteristics in patient sub-groups according to genotype (mean ± SD)

	Patients A/A	Patients A/G
TB (μmol/L)	198.94 ± 14.85	91.65 ± 15.70
CB (μmol/L)	95.52 ± 5.93	44.70 ± 6.15a
ALT (U/L)	131.54 ± 11.91	92.50 ± 10.01
AST (U/L)	281.29 ± 28.26	129.25 ± 12.43
γ-GT (U/L)	317.68 ± 47.64	77.00 ± 18.78

CB: Conjugated bilirubin.

^aP < 0.05.