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©2009 The WJG Press and Baishideng.
World J Gastroenterol. Nov 28, 2009; 15(44): 5604-5609
Published online Nov 28, 2009. doi: 10.3748/wjg.15.5604
Published online Nov 28, 2009. doi: 10.3748/wjg.15.5604
Table 1 Demographic data of the patients
Details | Frequency |
Age group (yr) | |
≤ 60 | 32 |
61–70 | 19 |
≥ 71 | 14 |
Sex | |
Male | 42 |
Female | 23 |
No. of procedures | |
Gastrectomy | 49 |
Colorectal resection1 | 9 |
Gastro-jejunal anastomosis | 2 |
Exploratory laparotomy | 5 |
TNM classification (Gastric cancer) | |
IA | 8 |
IB | 6 |
II | 7 |
IIIA | 10 |
IIIB | 4 |
IV | 12 |
Dukes classification (Colorectal) | |
A | 7 |
B | 0 |
C | 1 |
Table 2 Overall complications in both sexes
Complications | Frequency | |
Male | Female | |
Overall | 9 | 11 |
Intra-abdominal hemorrhage | 1 | 0 |
Anastomotic leak | 1 | 1 |
Abdominal infection | 2 | 1 |
Pyrexia of unknown origin | 7 | 9 |
Renal failure | 1 | 0 |
Respiratory failure | 0 | 1 |
Cardiac failure | 0 | 1 |
Hypotension | 0 | 1 |
MODS | 0 | 1 |
Gastroplegia or enteroplegia | 0 | 2 |
Anastomosis site bleeding | 1 | 1 |
Pleural effusion | 0 | 2 |
Seroperitoneum | 2 | 1 |
Death | 0 | 1 |
Table 3 Normal range of different hormones
Male | Female (postmenopause) | |
Estradiol (pg/mL) | 20-75 | 20-88 |
Progesterone (ng/mL) | 0.1-0.84 | 0.08-0.78 |
Testosterone (ng/mL) | 2.62-15.9 | 0.1-0.8 |
Table 4 Demographics and clinical characteristics according to sex
Male (n = 42) | Female (n = 23) | P value | |
Age (yr) | 60.9 | 58.1 | 0.356 |
Physiological score | 14 | 17 | 0.203 |
Operative severity score | 16 | 18 | 0.365 |
Complications (%) | 21.4 | 47.8 | 0.027 |
Baseline estradiol (pg/mL) | 23 | 12 | 0.320 |
Baseline progesterone (ng/mL) | 0.46 | 0.37 | 0.450 |
Baseline testosterone (ng/mL) | 3.26 | 0.23 | 0.000 |
Table 5 Significance of difference in testosterone level at different times
Complication | Baseline | POD1 | POD3 | POD5 | POD7 |
Overall | 0.008 | 0.002 | 0.007 | 0.001 | 0.000 |
Gastric disease | 0.025 | 0.008 | 0.026 | 0.005 | 0.005 |
Table 6 Level of testosterone in different sexes according to outcome
Time | Complications (male) | Complications (female) | ||||
Absent | Present | P value | Absent | Present | P value | |
Base | 3.66 | 2.74 | 0.104 | 0.23 | 0.29 | 0.689 |
POD1 | 0.91 | 0.87 | 0.141 | 0.40 | 0.23 | 0.268 |
POD3 | 1.54 | 0.85 | 0.046 | 0.19 | 0.20 | 0.948 |
POD5 | 2.20 | 0.91 | 0.040 | 0.41 | 0.21 | 0.038 |
POD7 | 3.22 | 1.24 | 0.030 | 0.38 | 0.16 | 0.007 |
Table 7 Area under the ROC for testosterone
Time | Area | P value | 95% CI | |
Lower bound | Upper bound | |||
BASE | 0.729 | 0.016 | 0.562 | 0.897 |
POD1 | 0.801 | 0.002 | 0.658 | 0.945 |
POD3 | 0.756 | 0.007 | 0.593 | 0.919 |
POD5 | 0.813 | 0.001 | 0.664 | 0.963 |
POD7 | 0.835 | 0.000 | 0.692 | 0.977 |
Table 8 Sensitivity and specificity for different levels of testosterone
Testosterone level | Sensitivity | Specificity | |
Base | ≤ 1.95 | 70.0 | 68.9 |
POD1 | ≤ 0.43 | 60.0 | 84.4 |
POD3 | ≤ 0.45 | 73.3 | 80.0 |
POD5 | ≤ 0.24 | 60.0 | 90.0 |
POD7 | ≤ 0.32 | 66.7 | 92.0 |
- Citation: Sah BK, Chen MM, Peng YB, Feng XJ, Yan M, Liu BY, Fan QS, Zhu ZG. Does testosterone prevent early postoperative complications after gastrointestinal surgery? World J Gastroenterol 2009; 15(44): 5604-5609
- URL: https://www.wjgnet.com/1007-9327/full/v15/i44/5604.htm
- DOI: https://dx.doi.org/10.3748/wjg.15.5604