Sah BK, Chen MM, Peng YB, Feng XJ, Yan M, Liu BY, Fan QS, Zhu ZG. Does testosterone prevent early postoperative complications after gastrointestinal surgery? World J Gastroenterol 2009; 15(44): 5604-5609 [PMID: 19938202 DOI: 10.3748/wjg.15.5604]
Corresponding Author of This Article
Zhu Zheng Gang, Professor, Department of General Surgery & Shanghai Institute of Digestive Surgery, Rui Jin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200025, China. rjzhuzhenggang@hotmail.com
Article-Type of This Article
Brief Article
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Birendra Kumar Sah, Ming-Min Chen, Yi-Bing Peng, Xiao-Jing Feng, Min Yan, Bing-Ya Liu, Qi-Shi Fan, Zheng-Gang Zhu, Department of General Surgery & Shanghai Institute of Digestive Surgery, Rui Jin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200025, China
Author contributions: Zhu ZG participated in the design of the study and finally approved it, supervised the whole study and performed critical revision of the article; Sah BK designed the study, collected the data, and drafted the manuscript; Chen MM, Yan M, Liu BY and Fan QS assisted in data interpretation and drafting of the manuscript; Peng YB and Feng XJ were responsible for laboratory tests.
Supported by Shanghai Key Laboratory of Gastric Neoplasm, No. 09DZ2260200
Correspondence to: Zhu Zheng Gang, Professor, Department of General Surgery & Shanghai Institute of Digestive Surgery, Rui Jin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200025, China. rjzhuzhenggang@hotmail.com
Telephone: +86-21-64370045 Fax: +86-21-53821171
Received: July 20, 2009 Revised: September 20, 2009 Accepted: September 28, 2009 Published online: November 28, 2009
Abstract
AIM: To investigate the role of sex hormones in the early postoperative complications of gastrointestinal diseases.
METHODS: A total of 65 patients who underwent operations for gastric and colorectal diseases (mainly malignant diseases) were included in the study. Peripheral venous blood samples were collected at different times for analysis of estradiol, testosterone and progesterone. The only study endpoint was analysis of postoperative complications.
RESULTS: Patients of both sexes were uniform but postoperative complication rate was significantly higher in female patients (P = 0.027). There was no significant association of estradiol and progesterone with postoperative complications. Testosterone levels in complicated patients were significantly lower than in uncomplicated patients (P < 0.05). Area under the receiver operating characteristic curve showed that a lower value of testosterone was a predictor for higher complication rate (P < 0.05), and a lower value of testosterone at later times after surgery was a better predictor of complications.
CONCLUSION: Patients with low testosterone level were prone to higher postoperative complications, which was evident in both sexes. However, further studies are necessary to support this result.
