Therapeutic effect of caffeic acid phenethyl ester on cerulein-induced acute pancreatitis

Table 1 Pathological grading system in experimental AP

Edema	0	No edema
	1	Interlobular edema
	2	Moderate interlobular edema + intra-acinar edema
	3	Severe interlobular and intra-acinar edema
Inflammatory infiltration	0	No infiltration
	1	Intravascular margination of granulocytes
	2	Granulocytes present in the perivascular tissue
	3	Diffuse infiltration of entire pancreatic gland
Fat necrosis	0	No necrosis
	1	1-4 necrotic cells ( each microscopic area)
	2	5-10 necrotic cells
	3	11-16 necrotic cells

Table 2 Biochemical, values and pathological scores in cerulein-induced AP (mean ± SD)

Groups	TNF-α(pg/mL)	Amylase (U/L)	Lipase (U/L)	White blood cells	Edema	Leukocytic infiltration	Total pathological score	Fat necrosis
Sham	65.14 ± 1.7	665.14 ± 54	14.41 ± 1.7	9279 ± 1867	0.00	0.00	0.00	0.00
Control	63.29 ± 3.8	630.20 ± 64	14.92 ± 1.7	8755 ± 1098	0.00	0.00	0.00	0.00
AP	63.83 ± 3.8	4752 ± 1328b	112.3 ± 34.8b	8574 ± 1437	2.50 ± 0.5	2.80 ± 0.42	8.00	0.30 ± 0.48
CAPE 1	61.55 ± 8.0	1400 ± 680d	22.92 ± 6.9d	8407 ± 418	1.50 ± 0.7	2.50 ± 0.52	4.00c	0.00
CAPE 2	60.52 ± 6.5	1084 ± 533d	18.65 ± 3.7d	8940 ± 2746	0.50 ± 0.5d	2.40 ± 0.51	3.00c	0.00
Placebo 1	62.38 ± 9.5	4516 ± 749	49.2 ± 5.3	9267 ± 927	2.30 ± 0.6	2.70 ± 0.48	8.00	0.30 ± 0.48
Placebo 2	61.56 ± 2.5	4219 ± 235	52.54 ± 4.8	8544 ± 895	2.20 ± 0.6	2.70 ± 0.48	8.00	0.30 ± 0.48

^bP < 0.001 vs group 1 and 2;

^cP < 0.05,

^dP < 0.001 vs group 3.