Brief Articles
Copyright ©2009 The WJG Press and Baishideng.
World J Gastroenterol. Oct 14, 2009; 15(38): 4816-4822
Published online Oct 14, 2009. doi: 10.3748/wjg.15.4816
Table 1 Effect of Anogeissus latifolia extract (ALE) on CCl4-induced toxicity in rat hepatocytes (mean ± SE)
TreatmentViable cells (%)ALT (IU/L)AST (IU/L)
Cell control93.88 ± 0.8118.70 ± 0.4621.53 ± 0.63
Toxicant (1 mol/L CCl4)33.06 ± 11450.20 ± 0.6157.50 ± 0.94
Std Liv52 (250 μL/mL)85.84 ± 1.19 (86.7)a19.46 ± 0.35 (97.59)a24.10 ± 0.37 (92.85)a
ALE (250 μg/mL)57.63 ± 1.58 (40.39)a41.33 ± 0.62 (28.16)a44.53 ± 1.25 (36.05)a
ALE (500 μg/mL)77.60 ± 0.57 (73.72)a38.50 ± 0.45 (37.14)a32.80 ± 0.65 (68.66)a
ALE (1000 μg/mL)81.24 ± 1.67 (79.20)a22.23 ± 0.50 (88.48)a27.33 ± 0.69 (83.87)a
Table 2 Effect of Anogeissus latifolia on plasma biochemical parameters and lipid peroxidation in CCl4-intoxicated rats liver (n = 6, mean ± SE)
Treatment (n = 6)AST (IU/L)ALT (IU/L)ALP (IU/L)Lipid peroxidation nmol of MDA/mg protein
Normal88.17 ± 5.4754 ± 2.7249.5 ± 18.24.1 ± 0.5
CCl4 (500 μL/kg)254.9 ± 19.3c222.8 ± 10.14c328.5 ± 25.36a14.8 ± 1.3c
Liv52 (2 mL/kg)111.7 ± 8.7b71.4 ± 5.6b255 ± 24.1b5.4 ± 0.6b
ALE (300 mg/kg)117 ± 6.7b66.2 ± 6.1b258 ± 15.54b6.1 ± 0.5b