Clinicopathological significance of B-cell-specific Moloney murine leukemia virus insertion site 1 expression in gastric carcinoma and its precancerous lesion

Table 1 Expression of Bmi-1 in normal gastric mucosa, GC and precancerous lesion

Disease features	Cases (n)	Positive Bmi-1 expression rate			χ2	P
		-	+-+++	+-+++ (%)
N	162	127	35	21.6	74.844a	< 0.001
IM	82	17	65	79.3	16.510b	< 0.001
DYS	52	10	42	80.8	59.819c 13.067b	< 0.001
GC	162	77	85	52.5	33.088c	< 0.001

^aP < 0.001 vs IM;

^bP < 0.001 vs GC;

^cP < 0.001 vs N. N: Normal gastric mucosa; DYS: Dysplasia.

Table 2 Correlation between Bmi-1 expression and clinicopathological features of GC

Group	Cases (n)	Positive Bmi-1 expression rate			χ2	P
		-	+-+++	+-+++(%)
Gender					2.880	0.090
Male	116	60	56	50.0
Female	46	17	29	65.2
Age (yr)					3.658	0.056
≤ 60	82	46	36	43.9
> 60	80	31	49	61.3
Clinicopathological classification					11.190	0.001
EGC	30	6	24	80.0
AGC	132	71	61	46.2
Gross classification
EGC						0.641
I + IIc	19	3	16	84.2
III	11	3	8	72.7
AGC					6.122	0.013
BorI + BorII	25	19	6	24.0
BorIII + BorIV	107	52	55	51.4
WHO histological classification						< 0.001
PA	4	0	4	100.0
WDA	12	3	9	75.0
MDA	50	22	28	56.0		0.330a
PDA	75	42	33	44.0		0.063b
SRC	10	5	5	50.0
MA	9	4	5	55.6
UA	2	1	1	50.0
Lauren's classification					4.400	0.036
Intestinal type	75	29	46	61.3
Diffuse type	87	48	39	44.8
Lymph node metastasis					3.042	0.081
No	98	52	46	46.9
Yes	64	25	39	60.9

Fisher's exact test,

^aP = 0.330 vs PDA;

^bP = 0.063 vs PDA. EGC: Early gastric carcinoma; AGC: Advanced gastric carcinoma; PA: Papillary adenoma; WDA: Well-differentiated adenoma; MDA: Moderately differentiated adenoma; PDA: Poorly differentiated adenoma; MA: Mucinous adenoma; UA: Undifferentiated adenoma.

Table 3 Correlation between ki-67 and Bcl-2 expression and clinicopathological features of GC (Fisher's exact test)

Group	n	ki-67 expression	χ2	P	Bcl-2 expression	χ2	P
		+-+++(%)			+-+++(%)
Gender			0.584	0.445		0.558	0.455
Male	116	98 (84.5)			68 (58.6)
Female	46	41 (89.1)			24 (52.2)
Age (yr)			0.004	0.950		0.206	0.650
≤ 60	82	71 (86.6)			48 (58.5)
> 60	80	69 (86.3)			44 (55.0)
Clinicopathological classification				0.080		1.464	0.226
EGC	30	29 (96.7)			20 (66.7)
AGC	132	111 (84.1)			72 (54.5)
Gross classification
EGC				0.367			1.000
I + IIc	19	19 (100.0)			13 (68.4)
III	11	10 (90.9)			7 (63.6)
AGC			13.380	< 0.001		2.632	0.105
BorI + II	25	15 (60.0)			10 (40.0)
BorIII + IV	107	96 (89.7)			62 (57.9)
WHO’s histological classification			4.262	0.601		8.640	0.169
PA	4	4 (100.0)			3 (75.0)
WDA	12	11 (91.7)			8 (66.7)
MDA	50	45 (90.0)		1.000a	31(62.0)		1.000a
PDA	75	63 (84.0)		0.684b	35 (46.7)		0.229b
SRC	10	8 (80.0)			6 (60.0)
MA	9	8 (88.9)			8 (88.9)
UA	2	1 (50.0)			1 (50.0)
Lauren's classification			2.146	0.143		5.552	0.018
Intestinal type	75	68 (90.7)			50 (65.8)
Diffuse type	87	72 (82.8)			42 (48.8)
Lymph node metastasis			0.021	0.885		0.045	0.832
No	98	85 (86.7)			55 (56.1)
Yes	64	55 (85.9)			37 (57.8)

Fisher's exact test,

^aP = 1.000, 1.000 vs PDA;

^bP = 0.684, 0.229 vs PDA.

Table 4 Relation between expressions of Bmi-1, ki-67 and Bcl-2 in GC and IM

	Bmi-1 in GC			rk	P		Bmi-1 in IM			rk	P
	-	+					-	+
ki-67						ki-67
-	14	8	22	0.123	0.119	-	4	6	10	0.177	0.199
+	64	76	140			+	13	59	72
Bcl-2				0.157	0.043	Bcl-2				0.270	0.038
-	40	30	70			-	8	12	20
+	38	54	92			+	9	53	62
Total	78	84	162			Total	17	65	82