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World J Gastroenterol. May 7, 2009; 15(17): 2145-2150
Published online May 7, 2009. doi: 10.3748/wjg.15.2145
Clinicopathological significance of B-cell-specific Moloney murine leukemia virus insertion site 1 expression in gastric carcinoma and its precancerous lesion
Jing Zhao, Xiang-Dong Luo, Chun-Li Da, Yan Xin
Jing Zhao, Xiang-Dong Luo, Chun-Li Da, Yan Xin, The Fourth Laboratory of Cancer Institute, Department of Tumor Pathology of General Surgery Institute, First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
Author contributions: Zhao J designed and performed the majority of experiments and wrote the manuscript; Xin Y provided the vital instructions and financial support for the study and manuscript revision; Luo XD and Da CL participated in the experiment.
Correspondence to: Yan Xin, Professor, The Fourth Laboratory of Cancer Institute, Department of Tumor Pathology of General Surgery Institute, First Affiliated Hospital of China Medical University, 155 Nanjing North Street, Heping District, Shenyang 110001, Liaoning Province, China. yxin@mail.cmu.edu.cn
Telephone: +86-24-83282351
Fax: +86-24-83282375
Received: December 9, 2008
Revised: March 27, 2009
Accepted: April 3, 2009
Published online: May 7, 2009
Abstract

AIM: To explore the relation between B-cell-specific Moloney murine leukemia virus insertion site 1 (Bmi-1) expression and the clinicopathological features of gastric carcinoma (GC).

METHODS: Immunohistochemistry was used to detect the expression of Bmi-1 and ki-67. Double-labeling staining was used to display the distribution of Bcl-2+/ki-67- cells in 162 cases of GC and its matched normal mucosa and precancerous lesion.

RESULTS: The positive rate of Bmi-1 expression in GC (52.5%) was significantly higher than that in normal gastric mucosa (21.6%, χ2 = 33.088, P < 0.05). The Bmi-1 expression in GC was closely related with the Lauren’s and Borrmann’s classification and clinical stage (χ2 = 4.400, 6.122 and 11.190, respectively, P < 0.05). The expression of ki-67 was related to the Borrmann’s classification (χ2 = 13.380, P < 0.05). Bcl-2 expression was correlated with the Lauren’s classification (χ2 = 4.725, P < 0.05), and the Bmi-1 expression both in GC (rk = 0.157, P < 0.05) and in intestinal metaplasia (rk = 0.270, P < 0.05).

CONCLUSION: Abnormal Bmi-1 expression in GC may be involved in cell proliferation, apoptosis and cancerization. This marker can objectively indicate the clinicopathological characteristics of GC.

Keywords: B-cell-specific Moloney murine leukemia virus insertion site 1, Gastric carcinoma, Precancerous lesion, Cell proliferation, Apoptosis