Abnormal liver function and central obesity associate with work-related fatigue among the Taiwanese workers

Table 1 Baseline data and distribution of characteristics

Characteristic/Potential risk factor	Total (n = 1216)
NFR score	27.8 (21.6)
Age (yr)	34.6 (7.1)
Working year (yr)	9.1 (6.5)
Blood tests
ALT (U/dL)	31.5 (31.8)
AST (U/dL)	23.4 (16.1)
HDL-cholesterol (mg/dL)	56.2 (12.4)
Triglyceride (mg/dL)	122.3 (81.8)
Fasting blood sugar (mg/dL)	91.6 (22.1)
Hemoglobin (mg/dL)	14.7 (1.6)
White blood count (× 103/mL)	6.3 (1.7)
Anthropometric measures
Waist (cm)	81.0 (11.1)
Body mass index (kg/m2)	24.3 (3.8)
Systolic blood pressure (mmHg)	124.9 (15.8)
Diastolic blood pressure (mmHg)	80.5 (11.5)
Male gender n (%)	852 (70)
Shiftwork n (%)	400 (33)
Smoking1n (%)	126 (11)
Blood tests
Abnormal ALT n (%)	249 (21)
Hypo-HDL2n (%)	134 (11)
Hypertriglyceridemia2n (%)	309 (25)
Elevated fasting blood sugar2n (%)	167 (14)
Anemia3n (%)	29 (2)
Anthropometric measures
Central obesity2n (%)	274 (23)
Elevated blood pressure2n (%)	543 (45)

Abnormal ALT: > 40 mg/dL.

¹Recent one year and more than one pack a day: Yes vs no;

²Taiwanese metabolic syndrome criteria;

³Significant anemia: Hb < 11 for females or < 12 mg/dL for males.

Table 2 Distribution of potential risk factors according to the NFR after work score

Potential risk factor	NFR Tertiles			P1
	1st tertile (n = 409)	2nd tertile (n = 379)	3rd tertile (n = 428)
NFR score	6.8 (3.9)	22.4 (4.5)	52.6 (15.4)	-
AGE (yr)	34.6 (7.2)	34.3 (7.1)	34.8 (6.9)	0.571
Working year (yr)	8.9 (6.9)	8.7 (6.3)	9.5 (6.4)	0.251
Blood tests
ALT (U/dL)	29.2 (22.4)	31.2 (27.3)	34.0 (41.6)	0.035
AST (U/dL)	22.4 (8.9)	23.3 (14.2)	24.4 (21.9)	0.092
HDL-cholesterol (mg/dL)	57.6 (12.9)	56 (12.4)	55.1 (11.8)	0.004
Triglyceride (mg/dL)	120.6 (76.9)	121.7 (82.7)	124.5 (85.5)	0.489
Fasting blood sugar (mg/dL)	92.3 (28.1)	90.8 (14.1)	91.7 (21.3)	0.725
Hemoglobin (mg/dL)	14.7 (1.6)	14.6 (1.6)	14.7 (1.5)	0.898
White blood count (× 103/mL)	6.3 (1.9)	6.4 (1.6)	6.3 (1.6)	0.566
Anthropometric measures
Waist (cm)	80.7 (10.8)	80.9 (11.2)	81.4 (11.6)	0.394
Body mass index (kg/m2)	24.2 (3.7)	24.2 (4)	24.4 (3.8)	0.413
Systolic blood pressure (mmHg)	124.8 (15.3)	125.6 (16.3)	124.3 (15.9)	0.678
Diastolic blood pressure (mmHg)	80.1 (11.6)	80.9 (11.5)	80.4 (11.4)	0.725
Male gender n (%)	300 (73)	258 (68)	294 (69)	0.072
Shiftwork n (%)	87 (22)	125 (33)	188 (44)	< 0.001
Smoking2n (%)	32 (8)	38 (10)	56 (13)	0.007
Blood tests
Abnormal ALT n (%)	70 (17)	78 (21)	101 (24)	0.010
Hypo-HDL3n (%)	44 (11)	39 (10)	51 (12)	0.294
Hypertriglyceridemia3n (%)	103 (25)	91 (24)	115 (27)	0.285
Elevated fasting blood sugar3n (%)	58 (14)	51 (14)	58 (14)	0.397
Anemia4n (%)	11 (3)	10 (3)	8 (2)	0.217
Anthropometric measures
Central obesity3n (%)	84 (21)	76 (20)	114 (27)	0.017
Elevated blood pressure3n (%)	169 (41)	186 (49)	188 (44)	0.232

Abnormal ALT: > 40 mg/dL. ¹P of student’s t-test between the top- vs bottom-NFR tertile for the continuous variables; Cochran-Armitage Trend Test for categorical variables among tertiles;

²Recent one year and more than one pack a day: Yes vs no;

³Taiwanese metabolic syndrome criteria;

⁴Significant anemia: Hb < 11 for females or < 12 mg/dL for males.