Choledochoscope manometry about different drugs on the Sphincter of Oddi

Table 1 Single administration program

Group	Cases	Medication name	Medication dosage	Medication channel
H2-receptor blocking pharmacon	20	Famotidine	40 mg	intravenous injection
	20	Cimetidine	200 mg	intravenous injection
Protease inhibitor	25	Gabexate mesilate	2.5 mg/min	intravenous injection with micro pump continuing
	25	Ulinastatin	2500 U/min	intravenous injection with micro pump continuing
	25	Ulinastatin	5000 U/min	intravenous injection with micro pump continuing
Gastro kinetic agents	20	Domperidone	10 mg	Take orally
	20	Mosapride	5 mg	Take orally
	20	Tegaserod	12 mg	Take orally

Table 2 Effects of H₂-receptor blocking pharmacon on SO pressure (mean ± SD)

	Famotidine (n = 20)			Cimetidine (n = 20)
	Before administration	10 min after administration	20 min after administration	Before administration	10 min after administration	20 min after administration
SOBP (mmHg)	9.63 ± 8.48	5.92 ± 4.41	4.97 ± 6.53	9.63 ± 8.16a	4.96 ± 4.43a	3.10 ± 3.16b
SOCA (mmHg)	96.21 ± 53.12	85.31 ± 59.48	78.18 ± 64.01	106.55 ± 73.58	79.24 ± 59.93	52.09 ± 37.11c
SOF (times/min)	9.82 ± 3.18	10.57 ± 3.88	8.35 ± 2.01	8.30 ± 2.84	10.57 ± 2.82	11.44 ± 4.39
CDBP (mmHg)	5.09 ± 7.74	5.63 ± 5.33	2.42 ± 5.28	6.54 ± 4.16	9.03 ± 9.53	5.87 ± 5.07

9.63 ± 8.16 vs 4.96 ± 4.43,

^aP < 0.05; 9.63 ± 8.16 vs 3.10 ± 3.16,

^bP < 0.01; 106.55 ± 73.58 vs 52.09 ± 37.11,

^cP < 0.01.

Table 3 Effects of protease inhibitor on SO pressure (mean ± SD)

		Ulinastatin 2500 U (n = 25)	Ulinastatin 5000 U (n = 25)	Gabexate mesilate (n = 25)
SOBP (mmHg)	Before administration	11.53 ± 4.22	11.81 ± 5.21	14.33 ± 3.74
	10 min	11.96 ± 7.91	9.16 ± 5.97	12.31 ± 4.15
	20 min	9.25 ± 4.43	8.70 ± 4.50a	11.61 ± 4.50b
SOCA (mmHg)	Before administration	78.63 ± 35.96	65.21 ± 23.46	94.84 ± 39.64
	10 min	64.79 ± 22.25	63.73 ± 33.52	90.60 ± 38.69
	20 min	53.35 ± 25.52c	47.13 ± 21.53d	80.55 ± 27.58
SOF (t/min)	Before administration	6.67 ± 2.15	7.38 ± 2.58	7.01 ± 1.57
	10 min	6.03 ± 2.10	5.29 ± 2.39e	6.45 ± 1.24
	20 min	5.57 ± 1.92	4.65 ± 2.47f	6.14 ± 1.73
CDBP (mmHg)	Before administration	7.34 ± 3.06	9.06 ± 4.50	9.68 ± 3.25
	10 min	8.03 ± 3.97	8.51 ± 5.41	10.87 ± 4.55
	20 min	7.47 ± 4.21	8.80 ± 3.50	11.07 ± 4.05

11.81 ± 5.21 vs 8.70 ± 4.50,

^aP < 0.05; 14.33 ± 3.74 vs 11.61 ± 4.50,

^bP < 0.05; 78.63 ± 35.96 vs 53.35 ± 25.52,

^cP < 0.01; 65.21 ± 23.46 vs 47.13 ± 21.53,

^dP < 0.01; 7.38 ± 2.58 vs 5.29 ± 2.39,

^eP < 0.01; 7.38 ± 2.58 vs 4.65 ± 2.47,

^fP < 0.01.

Table 4 Effects of gastro kinetic agents on SO pressure

		Domperidone (n = 20)	Mosapride (n = 20)	Tegaserod (n = 20)
SOBP (mmHg)	Before administration	10.30 ± 4.99	12.56 ± 13.02	7.11 ± 4.08
	10 min	12.79 ± 13.47	5.36 ± 6.70	9.44 ± 5.25
	20 min	6.40 ± 3.66a	6.00 ± 5.74	12.93 ± 31.97
SOCA (mmHg)	Before administration	110.52 ± 37.80	83.44 ± 46.16	74.62 ± 26.06
	10 min	97.20 ± 59.96	45.06 ± 31.32c	71.74 ± 37.63
	20 min	68.67 ± 41.02b	52.48 ± 44.19	58.54 ± 37.19
SOF (t/min)	Before administration	6.84 ± 2.43	7.13 ± 3.21	6.55 ± 2.49
	10 min	8.03 ± 6.52	6.33 ± 3.07	6.07 ± 3.31
	20 min	8.86 ± 7.56	5.74 ± 2.41	5.88 ± 1.47
CDBP (mmHg)	Before administration	5.78 ± 6.59	3.92 ± 3.58	2.9 ± 3.71
	10 min	5.38 ± 2.23	1.74 ± 1.77	3.36 ± 2.98
	20 min	4.34 ± 4.75	1.95 ± 3.43	4.07 ± 5.27

10.30 ± 4.99 vs 6.40 ± 3.66,

^aP < 0.05; 110.52 ± 37.80 vs 68.67 ± 41.02,

^bP < 0.01; 83.44 ± 46.16 vs 45.06 ± 31.32,

^cP < 0.01.