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World J Gastroenterol. Oct 14, 2008; 14(38): 5907-5912
Published online Oct 14, 2008. doi: 10.3748/wjg.14.5907
Choledochoscope manometry about different drugs on the Sphincter of Oddi
Jing Kong, Shuo-Dong Wu, Xiao-Bo Zhang, Zhen-Sheng Li, Gang Shi, Wei Wang, Jun-Zhi Chen
Jing Kong, Shuo-Dong Wu, Xiao-Bo Zhang, Zhen-Sheng Li, Gang Shi, Jun-Zhi Chen, Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China
Wei Wang, Department of Pediatric Surgery, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China
Author contributions: Kong J and Wu SD contributed equally to this work; Kong J and Wu SD designed research; Kong J, Zhang XB, Li ZS, Shi G, Chen JZ, and Wang W performed research; Wang W contributed analytic tools; Zhang XB, Li ZS and Shi G analyzed data; and Kong J, Wu SD and Chen JZ wrote the paper.
Correspondence to: Shuo-Dong Wu, Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China. wushuodong@yahoo.cn
Telephone: +86-24-83956291 Fax: +86-24-86368876
Received: June 17, 2008
Revised: September 17, 2008
Accepted: September 24, 2008
Published online: October 14, 2008
Abstract

AIM: To assess the effects of H2-receptor blocking pharmacon, protease inhibitor, and gastro kinetic agents on the human Sphincter of Oddi (SO) motility by choledochoscope manometry.

METHODS: One hundred and seventy-five patients with T tube installed after cholecystectomy and choledochotomy were assessed by choledochoscope manometry. They were randomly assigned into groups of H2-receptor blocking pharmacon, protease inhibitor, and gastro kinetic agents. The Sphincter of Oddi basal pressure (SOBP), amplitude (SOCA), frequency of contractions (SOF), duodenal pressure (DP), and common bile duct pressure (CBDP) were scored and analyzed.

RESULTS: SOBP and SOCA were significantly decreased after Cimetidine administration, and no statistical difference was seen in the Famotidine group. In the Gabexate mesilate group, SOBP had decreased significantly. In the Ulinastatin group, SOCA decreased when Ulinastatin was given at the rate of 2500 U/min; when Ulinastatin administration was raised to 5000 U/min, SOBP, SOF and SOCA all experienced a fall. SOBP and SOCA for Domperidone and SOCA for Mosapride groups all decreased distinctly after administration.

CONCLUSION: The regular dosage of Cimetidine showed an inhibitory effect on the motility of SO, while Famotidine had no obvious effects otherwise. Gabnexata mesilate, Ulinastatin and gastro kinetic agents also showed inhibitory effects on the SO motility.

Keywords: Sphincter of Oddi; Medicamentum; Choledochoscope manometry