Gene expression and MR diffusion-weighted imaging after chemoembolization in rabbit liver VX-2 tumor model

Table 1 Gene expression of different areas of VX-2 tumour and the normal parenchyma around the tumor (%)

	PCNA	nm23	Bax	E-cad
Normal parenchyma	8.28 ± 5.61	16.53 ± 14.66	40.00 ± 23.72	78.15 ± 18.35
Tumor outer layer	65.45 ± 3.43	1.74 ± 4.07	1.91 ± 2.66	6.18 ± 7.55
Tumor periphery area	72.73 ± 14.23	0.42 ± 0.64	1.05 ± 1.09	1.96 ± 1.79
Tumor center area	58.37 ± 15.25	6.74 ± 10.13	2.16 ± 4.59	1.55 ± 3.65

Table 2 Dynamic information of the gene expression in the peripheral area of VX-2 tumor and the normal parenchyma around the tumor (%)

Time	Area	PCNA	nm23	Bax	E-cad
A time	E	72.73 ± 14.23	0.42 ± 0.64	1.05 ± 1.09	1.96 ± 1.79
	F	8.28 ± 5.61	16.53 ± 14.66	40.00 ± 23.72	78.15 ± 18.35
B time	E	80.04 ± 22.84	2.29 ± 1.58	0.86 ± 1.44	2.87 ± 2.04
	F	4.04 ± 2.06	57.35 ± 28.36	81.22 ± 23.31	86.41 ± 12.65
C time	E	92.60 ± 4.76	7.56 ± 8.88	0.45 ± 0.57	0.93 ± 1.48
	F	21.87 ± 24.59	67.64 ± 30.54	85.63 ± 20.51	91.03 ± 9.65
D time	E	87.63 ± 7.12	4.14 ± 4.71	0.78 ± 1.05	1.07 ± 0.81
	F	19.38 ± 17.74	40.84 ± 34.90	87.08 ± 10.16	91.03 ± 5.11

A time is before chemoembolization or on 21th day after implantation. B time, C time, and D time represent samples obtained after 16 h, 32 h and 48 h after chemoembolization respectively. E indicates the peripheral area of VX-2 tumor and F normal parenchyma around VX-2 tumor.

Table 3 ADC values of the tumor and normal parenchyma (mean ± SD, × 10^-3 mm²/s)

	ADC in tumor periphery area		ADC in normal parenchyma
	b = 100	b = 300	b = 100	b = 300
A time	1.71 ± 0.27	1.48 ± 0.23	2.71 ± 0.42	2.30 ± 0.40
B time	1.24 ± 0.22	1.12 ± 0.20	2.10 ± 0.54	1.65 ± 0.37
C time	1.48 ± 0.37	1.23 ± 0.16	2.10 ± 0.49	1.97 ± 0.29
D time	1.57 ± 0.23	1.40 ± 0.18	2.43 ± 0.33	2.06 ± 0.23

A time is before chemoembolization or on the 21th day after implantation. B time, C time, and D time represent samples obtained after 16 h, 32 h and 48 h after chemoembolization respectively.