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©2008 The WJG Press and Baishideng Publishing.
World J Gastroenterol. Aug 14, 2008; 14(30): 4745-4752
Published online Aug 14, 2008. doi: 10.3748/wjg.14.4745
Published online Aug 14, 2008. doi: 10.3748/wjg.14.4745
Table 1 Main clinical, biochemical and histological data of the HIO patients (as a whole and according to gender) and HFE controls
HIO | ||||||
HIO (n = 81) | P | HFE-HH (n = 57) | Men (n = 67) | P | Women (n = 14) | |
Age (yr) | 52 (28-76) | > 0.05 | 50 (26-71) | 54 (28-76) | > 0.05 | 51 (29-70) |
Transferrin saturation (%) | 39 (21-118) | < 0.0001 | 76 (29-100) | 38 (21-118) | 0.02 | 56 (28-99) |
Serum ferritin (μg/L) | 982 (413-5050) | > 0.05 | 1100 (274-10 990) | 964 (413-5050) | > 0.05 | 1286 (520-3987) |
AST (U/L) | 27 (12-174) | > 0.05 | 27 (17-87) | 27 (12-174) | > 0.05 | 28 (13-65) |
ALT (U/L) | 38 (11-271) | > 0.05 | 43 (11-114) | 38 (14-271) | > 0.05 | 36 (11-118) |
Total Iron Score | 19 (12-46) | 0.0071 | 24 (8-49) | 18 (12-40) | 0.0006 | 32 (12-46) |
Hepatocytic iron score | 15 (6-27) | 0.001 | 18 (3-27) | 12 (6-27) | 0.0022 | 21 (9-27) |
Sinusoidal iron score | 5 (3-8) | < 0.0001 | 3 (0-10) | 5 (3-7) | > 0.05 | 6 (3-8) |
Portal iron score | 0 (0-12) | 0.0002 | 2 (0-12) | 0 (0-8) | < 0.0001 | 3.5 (0-12) |
SIS/TIS | 0.25 (0.09-0.5) | < 0.0001 | 0.13 (0-0.63) | 0.25 (0.10-0.5) | 0.001 | 0.16 (0.09-0.29) |
HHII | 0.38 (0.20-1.21) | 0.0012 | 0.53 (0.15-0.97) | 0.36 (0.20-1.08) | 0.004 | 0.64 (0.23-1.21) |
Hepatic fibrosis (Ishak’s score) | 34 (42) | > 0.05 | 33 (57.8) | 26 (38.8) | > 0.05 | 8 (57.1) |
Hepatic cirrhosis (Ishak’s score) | 7 (8.6) | 0.027 | 13 (22.8) | 3 (4.5) | 0.015 | 4 (28.6) |
Patients with hepatic steatosis | 47 (58) | 0.015 | 20 (36.3) | 41 (61.2) | > 0.05 | 6 (42.9) |
Patients with moderate-severe hepatic steatosis | 35 (43.2) | < 0.0001 | 6 (10.5) | 31 (46.3) | > 0.05 | 4 (28.6) |
Metabolic syndrome | 20 (24.7) | > 0.05 | 91 (16.1) | 19 (28.4) | > 0.05 | 1 (7.1) |
Table 2 Correlation between total iron score (TIS) and several parameters in HIO patients
r | P | |
Hepatocytic iron score | 0.94 | < 0.0001 |
Sinusoidal iron score | 0.54 | < 0.0001 |
Portal iron score | 0.58 | < 0.0001 |
Serum ferritin (μg/L) | 0.53 | < 0.0001 |
Transferrin saturation (%) | 0.43 | < 0.0001 |
Age (yr) | 0.23 | 0.04 |
Hepatic fibrosis | 0.28 | 0.012 |
Body mass index (kg/m2) | -0.48 | < 0.0001 |
Degree of hepatic steatosis | -0.53 | < 0.0001 |
No. of components of MS | -0.33 | 0.0026 |
HOMA index | -0.3 | 0.0125 |
Table 3 Correlation between number of MS components and several parameters in HIO patients
r | P | |
Age (yr) | 0.3 | 0.0055 |
Degree of hepatic steatosis (%) | 0.57 | < 0.0001 |
HOMA index | 0.59 | < 0.0001 |
Transferrin saturation (%) | -0.25 | 0.0293 |
Total iron score | -0.33 | 0.0053 |
Histological hepatic iron index | -0.53 | < 0.0001 |
Sinusoidal iron score/Total iron score | 0.13 | > 0.05 |
Table 4 Iron indices in patients according to the presence of ≥ 2 components of MS or steatosis
Number of MS components | Hepatic steatosis | |||||
0-1 (n = 34) | P | ≥2 (n = 47) | Absent (n = 34) | P | Present (n = 47) | |
Transferrin saturation (%) | 44 (28-118) | 0.0058 | 36 (21-99) | 39 (23-118) | > 0.05 | 39 (21-76) |
Total Iron Score | 24 (12-46) | 0.0008 | 17 (12-39) | 24.5 (12-46) | < 0.0001 | 16 (12-39) |
HHII | 0.51 (0.3-1.21) | < 0.0001 | 0.33 (0.2-0.57) | 0.43 (0.23-1.1) | 0.0004 | 0.34 (0.19-1.2) |
SIS/TIS | 0.21 (0.1-0.5) | 0.0185 | 0.25 (0.11-0.4) | 0.22 (0.1-0.5) | 0.032 | 0.25 (0.09-0.4) |
MS components ≥ 2 | - | - | 11 (32) | < 0.0001 | 36 (77) | |
Degree of hepatic steatosis (%) | 0 (0-80) | < 0.0001 | 40 (0-98) | - | - |
- Citation: Riva A, Trombini P, Mariani R, Salvioni A, Coletti S, Bonfadini S, Paolini V, Pozzi M, Facchetti R, Bovo G, Piperno A. Revaluation of clinical and histological criteria for diagnosis of dysmetabolic iron overload syndrome. World J Gastroenterol 2008; 14(30): 4745-4752
- URL: https://www.wjgnet.com/1007-9327/full/v14/i30/4745.htm
- DOI: https://dx.doi.org/10.3748/wjg.14.4745