Characteristics and pathological mechanism on magnetic resonance diffusion-weighted imaging after chemoembolization in rabbit liver VX-2 tumor model

Table 1 ADC values of tumor and normal parenchyma after Chemoembolization

Group	VX-2 tumor periphery areas		VX-2 tumor center areas		Hepatic normal parenchyma
	b = 100	b = 300	b = 100	b = 300	b = 100	b = 300
Control	1.71 ± 0.27	1.48 ± 0.23	1.77 ± 0.36	1.55 ± 0.30	2.71 ± 0.42	2.30 ± 0.40
6 h	1.56 ± 0.40	1.36 ± 0.18	1.97 ± 0.49	1.79 ± 0.37	2.44 ± 0.53	1.87 ± 0.31
16 h	1.24 ± 0.22	1.12 ± 0.20	1.56 ± 0.40	1.69 ± 0.35	2.10 ± 0.54	1.65 ± 0.37
32 h	1.48 ± 0.37	1.23 ± 0.16	1.99 ± 0.32	1.66 ± 0.31	2.10 ± 0.49	1.97 ± 0.29
48 h	1.57 ± 0.23	1.40 ± 0.18	2.04 ± 0.54	1.82 ± 0.27	2.43 ± 0.33	2.06 ± 0.23
Total	1.51 ± 0.33	1.32 ± 0.23	1.87 ± 0.45	1.70 ± 0.32	2.36 ± 0.51	1.97 ± 0.38

Data are expressed as mean ± SD × 10^-3 mm²/s; ADC: Apparent diffusion coefficient.

Table 2 Dynamic information of cellular edema after chemoembolization (%) (mean±SD)

	Control	16 h	32 h	48 h
Normal parenchyma	24.90 ± 11.69	72.12 ± 34.48	63.89 ± 29.87	38.00 ± 24.57
Tumor periphery areas	18.16 ± 10.35	86.06 ± 16.01	81.18 ± 20.03	96.66 ± 4.76

Table 3 Manifestations of VX-2 tumor pathology after chemoembolization

	Cellular membrane		Cellular necrosis
	0	1		1	2	3
Normal parenchyma (Control)	8	2	7	3
Tumor periphery areas (Control)	10				9	1
Normal parenchyma (16 h)	7	3	7	1	2
Tumor periphery areas (16 h)	10			2	4	4
Normal parenchyma (32 h)	7	3	7	1	2
Tumor periphery areas (32 h)	10				3	7
Normal parenchyma (48 h)	6	4	8	2
Tumor periphery areas (48 h)	10				4	6

Cellular membrane: 0-clear and complete; 1-unclear and non-complete. Cellular necrosis: 0-cellular structure existing and cellular membrane complete; 1-many cells dissolving and cellular membrane disappearing; 2-minute cellular coagulation necrosis; 3-extensive cellular coagulation necrosis.