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©2007 Baishideng Publishing Group Co.
World J Gastroenterol. Sep 14, 2007; 13(34): 4620-4625
Published online Sep 14, 2007. doi: 10.3748/wjg.v13.i34.4620
Published online Sep 14, 2007. doi: 10.3748/wjg.v13.i34.4620
Table 1 Biological function of genes with down-regulated expression
Gene | Chromosomal localization | Biological function | Cy5/Cy3 |
NDP | Xp11.4 | Cross-cell signal transmission, signal transduction, NS development | 4.509 |
SSX4 | Xp11.23 | Transcription regulation, immunoreaction | 4.044 |
CASP1 | 11q23 | Positive regulation of I-kappaB kinase/NF-kappaB cascadereaction, signal transduction, apoptosis | 3.754 |
HPRT1 | Xq26.1 | Cytolysis, lymphocyte proliferation, purine nucleotide synthesis | 3.715 |
TM4SF2 | Xp11.4 | ECM | 3.554 |
DXS1283E | Xp22.3 | Unkown | 3.418 |
DPYS | 8q22 | NS development, signal transduct-ion, nucleotide metabolism | 3.386 |
TYRP1 | 9p23 | Cell metabolism, melanin synthesis | 3.358 |
CADPS | 3p21.1 | Calcium-regulated Exocytosis | 3.238 |
MCF2 | Xq27 | Cytokeleton | 3.187 |
COL4A6 | Xq22 | ECM and ECM synthesis | 3.201 |
F13A1 | 6p25.3-p24.3 | Transcriptional control | 3.108 |
HTR2C | Xq24 | IP3-induced signal pathway | 3.061 |
IL13RA1 | Xq24 | ECM | 3.050 |
OGT | Xq13 | Signal transduction | 3.030 |
TOSO | 1q32.1 | Defence reaction, anti-apoptosis | 2.994 |
MAB21L1 | 13q13 | Positive regulation of cell proliferation, visual development | 2.990 |
CYBB | Xp21.1 | Cross-cell signal transmission, chemotaxis, inflammation, signal transduction | 2.972 |
STK9/CDKL5 | Xp22 | Microduct skeleton and its synthesis, histogenesis | 2.946 |
PTPRG | 3p21-p14 | PTK signal pathway | 2.878 |
ELAVL2 | 9p21 | Transcriptional control | 2.853 |
GLA | Xq22 | Osteoclast differentce regulation,bone resorption, cell adhere | 2.851 |
APXL | Xp22.3 | Channel protein of sodium ion | 2.839 |
SERPINA7 | Xq22.2 | ECM, transport of TH | 2.833 |
Table 2 Biological function of genes with up-regulated expression
Gene | Chromosomal localization | Biological function | Cy5/Cy3 |
SZF1 | 3p21 | Transcriptional control | 0.181 |
MMP14 | 14q11-q12 | Incision enzyme, proteolysis | 0.186 |
WIT-1 | 11p13 | Cell proliferation | 0.189 |
LOC253012 | 7q21.3 | Gas exchange, cell adhere, early nerve difference and axonogenesis | 0.201 |
OPCML | 11q25 | Cell adhere, nerve identification | 0.239 |
PLAU | 10q24 | Chemotaxis, proteolysis, transduction | 0.258 |
MYC | 8q24.12-q24.13 | Positive-regulated cell proliferation, inhibit cell cycle, balance of iron ion, mRNA synthesis control | 0.274 |
SNTB1 | 8q23-q24 | Muscle contraction, skelet-matrix adhere | 0.281 |
SERPINESL | 7q21.3-q22 | Ser incision enzyme inhibitor, cell component, angiogenetic regulation | 0.290 |
C20A1 | 2q11-q14 | PCD transport, cell component | 0.294 |
SPTBN1 | 2p21 | Cytokeleton | 0.298 |
GNAS | 20q13.2-q13.3 | Energy metabolism, G-protein signal pathway, signal transduction | 0.302 |
PCOLCE | 7q22 | Proteolysis, cell component | 0.303 |
ENPP2 | 8q24.1 | Cell movement, G-protein signal pathway, phosphorylation metabolism, lytic activity p'tase activity, transcription | 0.309 |
CDK6 | 7q21-q22 | Proliferation, cell cycle, protein conjunct | 0.315 |
HIST2H2BE | 1q21-q23 | Chromosome component and synthesis | 0.323 |
ZNF137 | 19q13.4 | Transcription control, ion binding | 0.332 |
IL1B | 2q14 | Inflammation, proliferation, chemotaxis | 0.336 |
IL1A | 2q14 | Apoptosis, proliferation, transduction, chemotaxis | 0.343 |
MTSS1 | 8p22 | Actin component and synthesis, cell adhere, cell movement, PTK signal pathway, muscle and NS development, internalization | 0.346 |
ACHE | 7q22 | Muscle contraction, transduction | 0.353 |
EPHB4 | 7q22 | Proliferation, organ-formation, angiogenesis | 0.368 |
AZGP1 | 7q22.1 | Cell member component | 0.376 |
PDE4DIP | 1q12 | Protein synthesis, actin component | 0.377 |
PITPN | 17p13.3 | PHL transport | 0.379 |
MEOX1 | 17q21 | Growth | 0.386 |
GNB2L1 | 5q35.3 | Intercellular signal cascade reaction, protein localization, transduction, PKC | 0.394 |
MERTK | 2q14.1 | Transduction, cross-cell signal transmission, protein phosphorylation | 0.405 |
CUTL1 | 7q22.1 | Transcription control | 0.419 |
FCGR2A | 1q23 | Immune reaction, signal switch, defence reaction, B cell proliferation | 0.428 |
PAX8 | 2q12-q14 | Organ-formation, transcription control, metanephros development, mRNA synthesis | 0.442 |
Table 3 Functional classification of differentially expressed genes
Type of gene | Down-regulatedgenes (n) | Rate ofdown-regulatedgenes (%) | Up-regulatedgenes (n) | Rate ofup-reguletedgenes (%) |
Metabolism-associated | 18 | 14.88 | 3 | 12.50 |
Cell proliferation | 30 | 24.79 | 3 | 12.50 |
Cell cycle | 16 | 13.22 | 0 | 0 |
Signal transduction | 18 | 14.88 | 8 | 33.30 |
Cytokelet | 8 | 6.61 | 1 | 4.17 |
Transcription control | 18 | 14.88 | 4 | 16.67 |
Cell adhere | 11 | 9.09 | 1 | 4.17 |
Cell apoptosis | 8 | 6.61 | 2 | 8.33 |
Cell differentiation | 14 | 11.57 | 4 | 16.67 |
Immune-associated | 14 | 11.57 | 2 | 8.33 |
ECM | 6 | 4.96 | 1 | 4.17 |
- Citation: Li H, Cao HF, Li Y, Zhu ML, Wan J. Changes in gene-expression profiles of colon carcinoma cells induced by wild type K-ras2. World J Gastroenterol 2007; 13(34): 4620-4625
- URL: https://www.wjgnet.com/1007-9327/full/v13/i34/4620.htm
- DOI: https://dx.doi.org/10.3748/wjg.v13.i34.4620