Hypoestoxide inhibits tumor growth in the mouse CT26 colon tumor model

Table 1 Oral administration of HE inhibits the growth of s.c. implanted CT26 colon tumor in BALB/c mice

	Tumor volume (mm3)
Drug	Dose(mg/kg per day)	(d 18)(mean ± SE)	MST (d)(mean ± SE)	ILS (%)
"Vehicle control (PBS/DMSO)"	0	1542.8 ± 330	34.0 ± 6.2	0
HE	1 × 10	738.7 ± 158	43.0 ± 1.2	25
HE	5 × 10	582.3 ± 116	77.0 ± 4.2	126
HE	50 × 1	288.6 ± 188	52.7 ± 3.0	54
5-FU	25 × 1	911.1 ± 144	48.0 ± 3.6	40
5-FU	100 × 1	486.7 ± 171	59.7 ± 4.8	75
5-FU + HE	(5-FU) 25 × 1 + (HE) 1 × 10		57.7 ± 4.0	69

PBS/DMSO: phosphate buffered saline/dimethyl sulfoxide; MST: mean survival times; ILS: increased life spans. MST: 75.0 ± 3.8 (HE-treated mice at 5 mg/kg × 10) vs Vehicle control (30.0 ± 4.1), ILS: 150% (HE-treated mice) vs 0% (Vehicle control mice), P < 0.01.