Effects of long term hydrophilic bile acid therapy on in vitro contraction of gallbladder muscle strips in patients with cholesterol gallstones

Table 1 Response of gallbladder strips against KCl and increasing CCK-8 concentrations (mean ± SD)

Agent	GroupI	Group II	Group III	P
	(n = 14)	(n = 14)	(n = 14)
CCK-8
10-10 M	0.21 ± 0.02 g	0.25 ± 0.02 g	0.20 ± 0.01 g	< 0.001
10-9 M	0.32 ± 0.02 g	0.37 ± 0.04 g	0.26 ± 0.02 g	< 0.001
10-8 M	0.42 ± 0.04 g	0.48 ± 0.05 g	0.36 ± 0.04 g	< 0.001
10-7 M	1.20 ± 0.04 g	1.35 ± 0.10 g	1.04 ± 0.06 g	< 0.001
10-6 M	1.70 ± 0.010 g	1.85 ± 0.22 g	1.50 ± 0.10 g	< 0.001
KCl (0.25 mol/L)	3.50 ± 0.50 g	3.77 ± 0.45 g	3.30 ± 0.30 g	< 0.03
Basal	0.13 ± 0.03 g	0.14 ± 0.02 g	0.12 ± 0.05 g	> 0.05

G: gram; KCl: potassium chloride; CCK: cholecystokinine.