Expression of mutant type-p53 products in H pylori-associated chronic gastritis

doi:10.3748/wjg.v13.i10.1541

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Mar 14, 2007 (publication date) through Jan 27, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

H Pylori

World J Gastroenterol. Mar 14, 2007; 13(10): 1541-1546
Published online Mar 14, 2007. doi: 10.3748/wjg.v13.i10.1541

Table 1 Immunohistochemical detection agaisnt p53 (PAb 240) in gastric mucosa

					Number of positive cells perten crypts against p53 (PAb240)before eradication					Number of positive cells perten crypts against p53 (PAb240)6 mo after eradication
	Case	Sex	Age (yr)	Clinical diagnosis	A2	A1	IA	B1	B2	A2	A1	IA	B1	B2
H pylori positive	1	F	42	Gstric ulcer	0	0	0	0	0	0	0	0	0	0
H pylori positive	2	F	26	Duodenal ulcer	0	0	0	0	0	0	0	0	0	0
	3	M	64	Gastric ulcer	0	0	11.4	0	0	0.7	0	0	0	0
	4	M	64	Gastric ulcer	0	0	0	2.5	0	0	0	0	0	0
	5	M	56	Gastric ulcer	0	0.8	0	0	0	0	0	0	0	0
	6	M	50	Gastric ulcer	0	0	0	0	0	0	0	0	0	0
	7	M	45	Gastroduodenal ulcer	0	0	0	0	2.3	0	1.1	0	0	0
	8	M	52	Chronic gastritis	0	0	0	0	0	0	0	0	0	0
	9	M	60	Gastric ulcer	0	0	0	0.8	0	0.5	0	0	2.2	0
	10	F	71	Chronic gastritis	1.7	0	0.8	0.7	0	0	0	0	0	0
	11	M	60	Gastric ulcer	1.3	0	0	0	0	0	0	0	0	0
	12	M	55	Gastric ulcer	0	0	0	0	0	0	0	0	0	0
	13	M	42	Gastroduodenal ulcer	2.4	2.2	0	0	0	0	0	0	0	0
	14	M	68	Gastric ulcer	0	0	0	0	0	0	0	0	0	0
	15	M	67	Chronic gastritis	0	0	0	0	0	0	0	0	0	0
	16	M	57	Chronic gastritis	0	0	0	2	0	0	0	0	0	0
	17	F	77	Gastric ulcer	0	0	0	1.7	0	0	0	0	0	0
	18	F	51	Chronic gastritis	0	0	0	0.7	0	0	0	0	0	0
	19	M	64	Gastric ulcer	0	0	0	0	2.3	0	0	0	0	0
	20	F	57	Chronic gastritis	0	0	0	0	0	0	0	0	0	0
	21	M	51	Chronic gastritis	0	0	0	0	0	0	0	0	0	0
	22	F	75	Chronic gastritis	5.7	0	3.3	0	0.8	0	0	0	0	0
	23	F	65	Chronic gastritis	0.5	0	0	0	0	0	0	0	0	0
	24	F	51	Chronic gastritis	0.6	0	2.7	0	4.2	0	0	0	0	0
	25	M	53	Gastric ulcer	7.5	2.7	5	2.1	0	6	0	0	0	0
	26	M	68	Chronic gastritis	0.9	2.9	0	0	0	0	0	0	0	0
	27	M	50	Chronic gastritis	0	1.3	0.6	0	0	0	0	0	0	0
	28	F	78	Chronic gastritis	0	0	0	2.2	1.8	0	0	0	0	0
	29	M	58	Gastric ulcer	0	0	2.5	0	0	0	0	0	0	0
	30	M	74	Chronic gastritis	0	0	0	1.7	4.5	0	0	0	0	0
	33	M	48	Chronic gastritis	1.1	0	3.8	0	3.8	0	0	0	1.7	0
	34	F	68	Chronic gastritis	0	0	0	0	0	0	0	0	0	0
	35	F	46	Gastric ulcer	3.3	0	7.5	6	0	0	0	0	0	0
	36	M	64	Duodenal ulcer	0	0	0	6.7	0	2	1.7	0	0	5
	37	M	42	Chronic gastritis	0	0	0	0	0	0	0	0	0	0
	38	F	71	Chronic gastritis	0	0	0	0	0	0	0	0	0	0
	39	M	58	Chronic gastritis	0	1	0.8	0	0	0	0	0	0	0
	40	F	46	Chronic gastritis	0	0	0	0	0	0	0	0	0	0
	41	M	76	Chronic gastritis	0.9	3	2.2	1.7	1.7	0	0	0	0	0
	42	M	51	Chronic gastritis	2.9	0	3.1	5.4	7.7	0	0	0	0	0
H pylori negative	43	M	25		0	0	0	0	0
H pylori negative	44	M	49		0	0	0	0	0
	45	M	51		0	0	0	0	0
	46	M	68		0	0	0	0	0
	47	M	40		0	0	0	0	0
	48	F	64		0	0	0	0	0
	49	F	52		0	0	0	0	0
	50	M	59		0	0	0	0	0
	51	M	73		0	0	0	0	0
	52	F	59		0	0	0	0	0
	53	M	38		0	0	0	0	0

A1: Lesser curvature of the antrum; A2: Greater curvature of the antrum; IA: Lesser curvature of the angle; B1: Lesser curvature of the lower body; B2: Greater curvature of the upper body.

Table 2 Positive ratio of Immunohistochemical detection against p53 (PAb 240)

	Before eradication	6 mo after eradication
H pylori positive	66.7% (28 out of 42)	14.3% (6 out of 42)^b
H pylori negative	0% (0 out of 11)

^bP < 0.01 vs before eradication in H pylori positive group.

Table 3 The differences of updated Sydney system score between the group showed more than six positive cells for p53 (PAb240) per 10 gastric pits (group A) and the group showed less than five cells for p53 (PAb240) per 10 gastric pits (Group B)

Contents of updatedSydney system	Group	Biopsy points
Contents of updatedSydney system	Group	A2	A1	IA	B1	B2
H pylori	Group A	1.25 ± 0.25	0.50 ± 0.21	1.00 ± 0.21	0.88 ± 0.24	1.38 ± 0.21
	Group B	0.71 ± 0.18	0.88 ± 0.22	0.88 ± 0.21	1.13 ± 0.19	1.41 ± 0.17
Inflammation	Group A	2.20 ± 0.12	2.20 ± 0.12	2.10 ± 0.16	2.30 ± 0.13	1.90 ± 0.16
Inflammation	Group B	2.05 ± 0.18	1.99 ± 0.17	2.00 ± 0.17	2.00 ± 0.12	1.82 ± 0.12
Activity	Group A	1.40 ± 0.15	1.00 ± 0.23	1.20 ± 0.23	1.20 ± 0.23	1.30 ± 0.23
	Group B	1.06 ± 0.20	0.94 ± 0.18	1.00 ± 0.18	1.05 ± 0.16	0.94 ± 0.17
Atrophy	Group A	2.00 ± 0.14	1.75 ± 0.13	2.13 ± 0.28	2.00 ± 0.21	1.20 ± 0.30
	Group B	1.40 ± 0.15^a	1.57 ± 0.15	1.67 ± 0.18	1.07 ± 0.23^a	0.47 ± 0.21^a
Intestinal etaplasia	Group A	0.90 ± 0.31	2.10 ± 0.41	1.80 ± 0.40	1.30 ± 0.36	0.20 ± 0.12
Intestinal etaplasia	Group B	0.82 ± 0.27	1.12 ± 0.29^c	1.47 ± 0.32	1.11 ± 0.29	0.12 ± 0.12

A1: the lesser curvature of the antrum; A2: the greater curvature of the antrum; IA: smaller curvature of the angle; B1: and the lesser curvature of the middle corpus; B2: the greater curvature of the upper corpus.

^aP < 0.05 vs atrophy scores in group A,

^cP < 0.05 vs intestinal metaplasia scores in group A.

Citation: Kodama M, Murakami K, Okimoto T, Sato R, Watanabe K, Fujioka T. Expression of mutant type-p53 products in H pylori-associated chronic gastritis. World J Gastroenterol 2007; 13(10): 1541-1546
URL: https://www.wjgnet.com/1007-9327/full/v13/i10/1541.htm
DOI: https://dx.doi.org/10.3748/wjg.v13.i10.1541