Role of the HLA-DQ locus in the development of chronic gastritis and gastric carcinoma in Mexican patients

Table 1 HLA-DQB1 allele frequencies in Mexican patients with chronic gastritis according to H pylori status

DQB1*	H pylori +		H pylori -		Healthy
	n = 48		n = 32		n = 198
	n	af	n	af	n	af
*0401	11	0.229ab	2	0.062	0	0
*0301	10	0.208	5	0.156	34	0.171
*0302	7	0.145	11	0.343	48	0.242
*0501	5	0.104	1	0.031	12	0.060
*0201	3	0.062	4	0.125	33	0.166
*0304	2	0.034	0	0	1	0.005
*0602	1	0.017	1	0.031	15	0.075
*0601	1	0.017	3	0.093	0	0
*0603	1	0.017	0	0	4	0.020
*0604	1	0.017	0	0	3	0.015
*0303	1	0.017	1	0.031	0	0

af: Allele frequencies;

^aP = 0.04, vs H pylori -, OR = 4.46; 95% CI: 1.12-31.7;

^bP = 1 × 10^–7, vs healthy individuals, OR = 6.5, 95% CI: 4.73-8.54.

Table 2 HLA-DQA1 allele frequencies in Mexican patients with H pylori-associated chronic gastritis according to CagA status

DQA1*	CagA +		CagA -		Healthy
	n = 28		n = 20		n = 198
	n	af	n	af	n	af
*0501	15	0.535ab	2	0.100	45	0.227
*0401	5	0.178	6	0.300	33	0.166
*0301	4	0.142	6	0.300	51	0.257
*0101	1	0.035	3	0.150	20	0.101
*0201	1	0.035	1	0.050	22	0.111
*0303	1	0.035	0	0	0	0
*0102	1	0.035	1	0.050	17	0.085
*0103	0	0	0	0	5	0.040
*0104	0	0	2	0.100c	0	0
*0105	0	0	1	0.050	0	0
*0503	0	0	1	0.038	0	0
*0601	0	0	1	0.038	0	0
*0302	0	0	1	0.038	0	0

af: Allele frequencies;

^aP = 0.002, vs CagA-, OR = 10.38, 95% CI: 1.76-79.51;

^bP = 0.0005, vs healthy individuals, OR = 3.92, 95% CI: 1.62-9.55;

^cP = 0.008, vs CagA+ and healthy individuals, OR = 12; 95% CI: 7.71-18.68.

Table 3 HLA-DQB1 allele frequencies in Mexican patients with H pylori-associated chronic gastritis according to CagA status

DQB1*	CagA +		CagA -		Healthy
	n = 28		n = 20		n = 198
	n	af	n	af	n	af
*0301	7	0.250	3	0.150	34	0.171
*0302	3	0.107	5	0.250	48	0.242
*0401	3	0.107	8	0.400ab	0	0
*0201	2	0.071	1	0.050	33	0.166
*0304	2	0.071	0	0	0	0
*0501	0	0	5	0.250cd	12	0.060
*0602	1	0.035	0	0	15	0.075
*0601	1	0.035	0	0	0	0
*0603	0	0	1	0.050	4	0.020
*0604	1	0.035	0	0	3	0.015
*0303	0	0	1	0.038	0	0

af: Allele frequencies;

^aP = 1 × 10^-7, vs healthy individuals, OR = 17.5, 95% CI: 10.1–30.31;

^bP = 0.01, vs CagA + , OR= 5.67, 95% CI: 1.22-28.07;

^cP = 0.03, vs CagA +, OR = 9.0, 95% CI: 1.86-223.8;

^dP = 0.01, vs healthy individuals, OR = 5.17, 95% CI: 1.37-18.83.

Table 4 Haplotype allele frequencies in patients with chronic gastritis according to H pylori status

DQA1-DQB1*	H pylori+		H pylori-		Healthy
	n = 48		n = 32		n = 198
	n	af	n	af	n	af
0401–0401	10	0.172ab	1	0.031	0	0
0501–0301	10	0.172	3	0.093	27	0.136
0301–0302	11	0.189	10	0.312	48	0.242
0501–0201	8	0.137	2	0.062	10	0.050
0101–0501	5	0.086	0	0	10	0.050
0201–0201	3	0.051	0	0	22	0.111
0301–0401	2	0.034	1	0.031	0	0
0302-0302	1	0.017	0	0	0	0

af: Allele frequencies;

^aP = 1 × 10^-7, vs healthy individuals, OR = 6.08, 95% CI: 4.56–8.10;

^bP = 0.03, vs H pylori -, OR = 7.15, 95% CI: 1.2-158.8.

Table 5 HLA-DQB1 allele frequencies in Mexican patients with gastric cancer according to H pylori status

DQB1*	H pylori +		H pylori -		Healthy
	n = 8		n = 18		n = 198
	n	af	n	af	n	af
*0501	4	0.500a	5	0.277b	12	0.060
*0201	2	0.250	0	0	33	0.166
*0401	1	0.040	1	0.100	0	0
*0602	1	0.125	0	0	15	0.075
*0604	0	0	1	0.055	3	0.015
*0301	0	0.125	7	0.388	34	0.171
*0302	0	0.125	4	0.222	48	0.242

af: Allele frequencies;

^aP = 0.001, vs healthy individuals, OR = 15.5, 95% CI: 2.80-87.68;

^bP = 0.007, vs healthy individuals, OR = 5.96, 95% CI: 1.55-22.55.