Herrera-Goepfert R, Yamamoto-Furusho JK, Oñate-Ocaña LF, Camorlinga-Ponce M, Muñoz L, Ruiz-Morales JA, Vargas-Alarcón G, Granados J. Role of the HLA-DQ locus in the development of chronic gastritis and gastric carcinoma in Mexican patients. World J Gastroenterol 2006; 12(48): 7762-7767 [PMID: 17203517 DOI: 10.3748/wjg.v12.i48.7762]
Corresponding Author of This Article
Roberto Herrera-Goepfert, MD, Department of Pathology, Instituto Nacional de Cancerología, Av. San Fernando #22, Col. Sección XVI, Tlalpan, 14080 México, D.F., México. rhgoepfert@yahoo.com.mx
Article-Type of This Article
Gastric Cancer
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World J Gastroenterol. Dec 28, 2006; 12(48): 7762-7767 Published online Dec 28, 2006. doi: 10.3748/wjg.v12.i48.7762
Role of the HLA-DQ locus in the development of chronic gastritis and gastric carcinoma in Mexican patients
Roberto Herrera-Goepfert, Jesús K Yamamoto-Furusho, Luis F Oñate-Ocaña, Margarita Camorlinga-Ponce, Leopoldo Muñoz, Jorge A Ruiz-Morales, Gilberto Vargas-Alarcón, Julio Granados
Roberto Herrera-Goepfert, Department of Pathology, Instituto Nacional de Cancerología (INCan), Mexico City, Mexico
Jesús K Yamamoto-Furusho, Jorge A Ruiz-Morales, Julio Granados, Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Luis F Oñate-Ocaña, Department of Gastroenterology (INCan), Mexico City, Mexico
Margarita Camorlinga-Ponce, Leopoldo Muñoz, Medical Research Unit on Infectious and Parasitic Diseases, Hospital de Pediatría, Centro Médico Nacional Siglo XXI (CMN-SXXI), Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico
Gilberto Vargas-Alarcón, Cellular Biology Section, Department of Physiology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico
Jesús K Yamamoto-Furusho, Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Correspondence to: Roberto Herrera-Goepfert, MD, Department of Pathology, Instituto Nacional de Cancerología, Av. San Fernando #22, Col. Sección XVI, Tlalpan, 14080 México, D.F., México. rhgoepfert@yahoo.com.mx
Telephone: +52-55-56280466 Fax: +52-55-55734662
Received: September 22, 2006 Revised: September 28, 2006 Accepted: November 20, 2006 Published online: December 28, 2006
Abstract
AIM: To determine the HLA-DQ locus in Mexican patients with Chronic gastritis and gastric adenocarcinoma.
METHODS: Oligotyping for HLA-DQ locus was performed in 45 Mexican patients with chronic gastritis and 13 Mexican patients with diffuse-type gastric adenocarcinoma, and was then compared with 99 clinically healthy unrelated individuals. H pylori infection and CagA status were assessed in patients by enzyme-linked immunosorbent assay (ELISA) method.
RESULTS: We found a significant increased frequency of HLA-DQB1*0401 allele in H pylori-positive patients with chronic gastritis when compared with healthy subjects [19 vs 0%, P = 1 × 10-7, odds ratio (OR) = 4.96; 95% confidence interval (95% CI), 3.87-6.35]. We also found a significant increased frequency of HLA-DQB1*0501 in patients with diffuse-type gastric carcinoma in comparison with healthy individuals (P = 1 × 10-6, OR = 13.07; 95% CI, 2.82-85.14).
CONCLUSION: HLA-DQ locus may play a different role in the development of H pylori-related chronic gastritis and diffuse-type gastric adenocarcinoma in the Mexican Mestizo population.
