Cytotoxic T-lymphocyte antigen 4 gene polymorphisms and susceptibility to chronic hepatitis B

Table 1 Distribution of allele and genotype frequency of CTLA-4 +49, -318, -1172 polymorphisms in hepatitis B patients and controls

	Chronic hepatitis B n (%)	Controlsn (%)
+49 genotype frequency (P = 0.211)
G+A–	9 (17.6)	41 (27.3)
G+A+	16 (31.4)	52 (34.7)
G–A+	26 (51)	57 (38)
+49 allele frequency
G+	25 (49)	93 (62)
A+	42 (82.4)	109 (72.7)
–318 genotype frequency (P = 0.012)
T+C–	0 (0)	6 (4)
T+C+	10 (19.6)	10 (6.7)
T–C+	41 (80.4)	134 (89.3)
–318 allele frequency
T+	10 (19.6)	16 (10.7)
C+	51 (100)	44 (96)
–1172 genotype frequency (P = 0.061)
T+C–	36 (70.6)	108 (72)
T+C+	13 (25.5)	42 (28)
T–C+	2 (3.9)	0 (0)
–1172 allele frequency
C+	15 (29.4)	42 (28)
T+	49 (96.1)	150 (100)

Table 2 Relation between frequencies of genotypes of CTLA-4 +49, -318, -1172 CTLA-4 polymorphisms and mean AST and ALT levels in subjects with chronic hepatitis, chronic hepatitis on first course of treatment, inactive carrier, non-responders to first course of treatment

	TC 1172 genotype	Mean	SE
AST	1172 T+C–	35.1944	3.7008
	1172 T+C+	25.3077	2.3325
	1172 T–C+	35.0000	14.0000
	TC 318 genotype	Mean	SE
AST	318 T+C+	29.1000	5.8299
	318 T–C+	33.5366	3.1455
There are no valid cases for AST. Statistics cannot be computed.
	AG 49 genotype	Mean	SE
AST	49 G+A–	32.6667	6.5362
	49 G+A+	32.3750	3.9811
	49 G–A+	32.8462	4.3960
	TC 1172 genotype	Mean	SE
ALT	1172 T+C–	40.9167	5.0528
	1172 T+C+	28.9231	4.3742
	1172 T–C+	50.0000	20.0000
	TC 318 genotype	Mean	SE
ALT	318 T+C+	33.5000	7.0683
	318 T–C+	39.3659	4.4751
There are no valid cases for ALT. Statistics cannot be computed.
	AG 49 genotype	Mean	SE
ALT	49 G+A–	43.1111	9.3592
	49 G+A+	40.1875	5.7018
	49 G–A+	35.3077	5.9497

Table 3 Association between CTLA-4 +49 genotype polymorphism and state of disease in chronic hepatitis B patients

			State of disease				Total
			Healthy carrier	Under treatment	Refractory to treatment	Chronic hepatitis
AG +49 genotype	+49 G+A–	Count	5	2	2	0	9
		% within state of disease	19.2%	11.8%	40.0%	.0%	17.6%
	+49 G+A+	Count	6	7	0	3	16
		% within state of disease	23.1%	41.2%	.0%	100.0%	31.4%
	+49 G–A+	Count	15	8	3	0	26
		% within state of disease	57.7%	47.1%	60.0%	.0%	51.0%
Total		Count	26	17	5	3	51
		% within state of disease	100.0%	100.0%	100.0%	100.0%	100.0%

¹P = 0.043.