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©2006 Baishideng Publishing Group Co.
World J Gastroenterol. Jan 28, 2006; 12(4): 595-602
Published online Jan 28, 2006. doi: 10.3748/wjg.v12.i4.595
Published online Jan 28, 2006. doi: 10.3748/wjg.v12.i4.595
Table 1 Sources of antibodies and ratio of dilutions used in this study
Antibody | Source | Dilution |
CD117 monoclonal | Dako M7140 Clone104D2 | 1:50 |
CD 34 monoclonal | Dako M7161 CloneQBEnd10 | 1:200 |
Desmin monoclonal | Novocastra NCL-DES-DERII | 1:100 |
Clone DE-R-11 | ||
Smooth muscle | ||
actin monoclonal | Novocastra NCL-SMA Clone αsm | 1:50 |
S-100 polyclonal | Novocastra NCL-S100p | 1:1 500 |
P53 monoclonal | Dako | 1:200 |
Ki67 monoclonal | Dako MIB1 | 1:50 |
PCNA monoclonal | Dako M0879 | 1:50 |
Table 2 The correlation between labeling index of molecular markers and pathologic parameters
Tumor mitosis | Tumor size | P53 | Ki67 | PCNA | |
Tumor mitosis | CC = 0.319 | CC = 0.488 | CC = 0.394 | CC = 0.657 | |
P = 0.0011 | P < 0.0011 | P < 0.0011 | P < 0.0011 | ||
Tumor size | CC = 0.319 | CC = 0.285 | CC = 0.032 | CC = 0.206 | |
P = 0.0011 | P = 0.0041 | P = 0.751 | P = 0.0411 | ||
P53 | CC = 0.488 | CC = 0.285 | CC = 0.434 | CC = 0.508 | |
P < 0.0011 | P = 0.0041 | P < 0.0011 | P < 0.0011 | ||
Ki67 | CC = 0.394 | CC = 0.032 | CC = 0.434 | CC = 0.295 | |
P < 0.0011 | P = 0.751 | P < 0.0011 | P = 0.0031 | ||
PCNA | CC = 0.657 | CC = 0.206 | CC = 0.508 | CC = 0.295 | |
P < 0.0011 | P = 0.0411 | P < 0.0011 | P = 0.0031 |
Table 3 Univariate and multivariate analyses for disease free survival rates of individual parameters of GIST patients
Univariate | Multivariate | |||||
Risk | 95%CI | P | Risk | 95%CI | P | |
Age ≥60/<60 yr | 1.01 | 0.45–2.25 | 0.98 | – | – | – |
Gender M/F | 2.38 | 1.05–5.36 | 0.036a | – | – | 0.1 |
Tumor size ≥5/<5 cm | 6.16 | 1.83–20.6 | 0.003a | 3.43 | 1.12–11.8 | 0.025a |
Mitoses ≥5/<5/50 HPF | 6.30 | 2.49–15.9 | <0.001a | 3.28 | 1.25–8.59 | 0.009a |
Tumor location fundic-cardiac/body-antrum | 0.99 | 0.54–1.81 | 0.98 | – | – | – |
Hemoglobin ≥100/<100 | 2.21 | 0.86–5.63 | 0.095 | – | – | – |
Cell type spindle/non-spindle | 1.23 | 0.73–2.08 | 0.42 | – | – | – |
Cellularity low+intermediate/high | 1.26 | 0.82–2.16 | 0.38 | – | – | – |
Pleomorphism +/- | 0.82 | 0.36–1.89 | 0.65 | – | – | – |
P53 +/- | 12.1 | 2.83–51.3 | 0.001a | 6.45 | 1.45–28.7 | 0.002a |
Ki67 +/- | 2.52 | 1.12–5.68 | 0.026a | – | – | 0.41 |
PCNA above or below median | 2.97 | 1.23–7.17 | 0.015a | – | – | 0.42 |
CD 34 +/- | 3.07 | 0.41–22.7 | 0.27 | – | – | – |
SMA +/- | 1.34 | 0.53–3.37 | 0.54 | – | – | – |
Desmin +/- | 0.74 | 0.17–3.16 | 0.68 | – | – | – |
S-100 +/- | 2.19 | 0.65–1.37 | 0.20 | – | – | – |
Table 4 Univariate and multivariate analyses for overall survival rates of individual parameters of GIST patients
Univariate | Multivariate | |||||
Risk | 95%CI | P | Risk | 95%CI | P | |
Age ≥60/<60 yr | 0.90 | 0.39–2.06 | 0.81 | – | – | – |
Gender M/F | 2.68 | 1.16–6.20 | 0.021a | – | – | 0.097 |
Tumor size ≥5/<5 cm | 19.01 | 2.56–141.1 | 0.004a | 10.17 | 1.34–76.9 | 0.001a |
Mitoses ≥5/<5/50 HPF | 10.30 | 3.48–30.4 | <0.001a | 5.22 | 1.70–15.9 | 0.001a |
Tumor location fundic-cardiac/body-antrum | 1.07 | 0.58–1.96 | 0.81 | – | – | – |
Hemoglobin ≥100/<100 | 1.98 | 0.78–5.05 | 0.14 | – | – | – |
Cell type spindle/non-spindle | 1.29 | 0.76–2.18 | 0.34 | – | – | – |
Cellularity low+intermediate/high | 1.21 | 0.64–2.17 | 0.35 | – | – | – |
Pleomorphism +/- | 0.90 | 0.39–2.09 | 0.82 | – | – | – |
P53 +/- | 11.29 | 2.64–48.2 | 0.001a | 4.84 | 1.08–21.6 | 0.012a |
Ki67 +/- | 2.30 | 1.01–5.26 | 0.048a | – | – | 0.70 |
PCNA above or below median | 2.75 | 1.13–6.70 | 0.025a | – | – | 0.74 |
CD 34 +/- | 1.98 | 0.58–6.70 | 0.27 | – | – | – |
SMA +/- | 1.38 | 0.54–3.52 | 0.48 | – | – | – |
Desmin +/- | 0.76 | 0.18–3.27 | 0.72 | – | – | – |
S-100 +/- | 2.28 | 0.67–7.70 | 0.18 | – | – | – |
- Citation: Hu TH, Chuah SK, Lin JW, Chiu YC, Changchien CS, Wang CC, Chen YS, Yi LN, Chiu KW, Lee CM. Expression and prognostic role of molecular markers in 99 KIT-positive gastric stromal tumors in Taiwanese. World J Gastroenterol 2006; 12(4): 595-602
- URL: https://www.wjgnet.com/1007-9327/full/v12/i4/595.htm
- DOI: https://dx.doi.org/10.3748/wjg.v12.i4.595