Role of platelet-activating factor in pathogenesis of acute pancreatitis

Table 1 Important roles of PAF in pathogenesis of AP

Main pathogenesis of AP	Important roles of PAF
Excessive leukocyte stimulation	To facilitate adhesion, chemotaxis and degranulation and to mediate the production of inflammatory mediators of leukocytes, and to delay PMN apoptosis
Microcirculatory disorder	To modulate indirectly/directly microvascular permeability
Gut endothelial barrier dysfunction	To upregulate adhesion molecules, intercellular signals and leukocyte–endothelial cell interactions
Bacterial translocation	To depend on its ability to induce gut endothelial barrier dysfunction
Acinar cell necrosis and apoptosis	To mediate neutrophil chemotaxis and delay neutrophil apoptosis in the pancreas, but neutrophils convert acinar cells undergoing apoptosis into necrotic cells